Polyphenols and Their Metabolites in Renal Diseases

Detalhes bibliográficos
Autor(a) principal: Guerreiro, Íris
Data de Publicação: 2022
Outros Autores: Ferreira-Pêgo, Cíntia, Carregosa, Diogo, Santos, Cláudia N., Menezes, Regina, Fernandes, Ana S., Costa, João G.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/137725
Resumo: Funding Information: Funding: This work was supported by FCT–Fundação para a Ciência e a Tecnologia (grants UIDB/04567/2020 and UIDP/04567/2020 to CBIOS, PTDC/BIA-MOL/31104/2017, and PhD grants 2020.07813.BD to Í.G. and 2020.04630.BD to D.C.). C.F.-P. and R.M. are funded by FCT Scientific Employment Stimulus contract with the reference numbers CEEC/CBIOS/NUT/2018 and CEEC/04567/CBIOS/2020, respectively. Authors also acknowledge COFAC/ILIND–Cooperativa De Formação E Animação Cultural CRL/Instituto Lusófono de Investigação e Desenvolvimento (grant COFAC/ILIND/CBIOS/2/2021). Authors also acknowledge the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme under grant agreement No 804229. iNOVA4Health Research Unit (LISBOA-01-0145-FEDER-007344), which is co-funded by FCT/Ministério da Ciência e do Ensino Superior, through national funds, and by FEDER under the PT2020 Partnership Agreement.
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spelling Polyphenols and Their Metabolites in Renal DiseasesAn Overviewacute kidney injurychronic kidney diseasediabetic nephropathydrug-induced nephrotoxicitymetabolitespolyphenolsrenal cancerrenal diseasesFood ScienceMicrobiologyHealth(social science)Health Professions (miscellaneous)Plant ScienceSDG 3 - Good Health and Well-beingFunding Information: Funding: This work was supported by FCT–Fundação para a Ciência e a Tecnologia (grants UIDB/04567/2020 and UIDP/04567/2020 to CBIOS, PTDC/BIA-MOL/31104/2017, and PhD grants 2020.07813.BD to Í.G. and 2020.04630.BD to D.C.). C.F.-P. and R.M. are funded by FCT Scientific Employment Stimulus contract with the reference numbers CEEC/CBIOS/NUT/2018 and CEEC/04567/CBIOS/2020, respectively. Authors also acknowledge COFAC/ILIND–Cooperativa De Formação E Animação Cultural CRL/Instituto Lusófono de Investigação e Desenvolvimento (grant COFAC/ILIND/CBIOS/2/2021). Authors also acknowledge the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme under grant agreement No 804229. iNOVA4Health Research Unit (LISBOA-01-0145-FEDER-007344), which is co-funded by FCT/Ministério da Ciência e do Ensino Superior, through national funds, and by FEDER under the PT2020 Partnership Agreement.Kidney diseases constitute a worldwide public health problem, contributing to morbidity and mortality. The present study aimed to provide an overview of the published data regarding the potential beneficial effects of polyphenols on major kidney diseases, namely acute kidney injury, chronic kidney disease, diabetic nephropathy, renal cancer, and drug-induced nephrotoxicity. This study consists of a bibliographical review including in vitro and in vivo studies dealing with the effects of individual compounds. An analysis of the polyphenol metabolome in human urine was also conducted to estimate those compounds that are most likely to be responsible for the kidney protective effects of polyphenols. The biological effects of polyphenols can be highly attributed to the modulation of specific signaling cascades including those involved in oxidative stress responses, anti-inflammation processes, and apoptosis. There is increasing evidence that polyphenols afford great potential in renal disease protection. However, this evidence (especially when in vitro studies are involved) should be considered with caution before its clinical translation, particularly due to the unfavorable pharmacokinetics and extensive metabolization that polyphenols undergo in the human body. Future research should consider polyphenols and their metabolites that indeed reach kidney tissues.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)Centro de Estudos de Doenças Crónicas (CEDOC)RUNGuerreiro, ÍrisFerreira-Pêgo, CíntiaCarregosa, DiogoSantos, Cláudia N.Menezes, ReginaFernandes, Ana S.Costa, João G.2022-05-10T22:47:19Z2022-04-062022-04-06T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/137725eng2304-8158PURE: 43679127https://doi.org/10.3390/foods11071060info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:15:11Zoai:run.unl.pt:10362/137725Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:48:52.910410Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Polyphenols and Their Metabolites in Renal Diseases
An Overview
title Polyphenols and Their Metabolites in Renal Diseases
spellingShingle Polyphenols and Their Metabolites in Renal Diseases
Guerreiro, Íris
acute kidney injury
chronic kidney disease
diabetic nephropathy
drug-induced nephrotoxicity
metabolites
polyphenols
renal cancer
renal diseases
Food Science
Microbiology
Health(social science)
Health Professions (miscellaneous)
Plant Science
SDG 3 - Good Health and Well-being
title_short Polyphenols and Their Metabolites in Renal Diseases
title_full Polyphenols and Their Metabolites in Renal Diseases
title_fullStr Polyphenols and Their Metabolites in Renal Diseases
title_full_unstemmed Polyphenols and Their Metabolites in Renal Diseases
title_sort Polyphenols and Their Metabolites in Renal Diseases
author Guerreiro, Íris
author_facet Guerreiro, Íris
Ferreira-Pêgo, Cíntia
Carregosa, Diogo
Santos, Cláudia N.
Menezes, Regina
Fernandes, Ana S.
Costa, João G.
author_role author
author2 Ferreira-Pêgo, Cíntia
Carregosa, Diogo
Santos, Cláudia N.
Menezes, Regina
Fernandes, Ana S.
Costa, João G.
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
Centro de Estudos de Doenças Crónicas (CEDOC)
RUN
dc.contributor.author.fl_str_mv Guerreiro, Íris
Ferreira-Pêgo, Cíntia
Carregosa, Diogo
Santos, Cláudia N.
Menezes, Regina
Fernandes, Ana S.
Costa, João G.
dc.subject.por.fl_str_mv acute kidney injury
chronic kidney disease
diabetic nephropathy
drug-induced nephrotoxicity
metabolites
polyphenols
renal cancer
renal diseases
Food Science
Microbiology
Health(social science)
Health Professions (miscellaneous)
Plant Science
SDG 3 - Good Health and Well-being
topic acute kidney injury
chronic kidney disease
diabetic nephropathy
drug-induced nephrotoxicity
metabolites
polyphenols
renal cancer
renal diseases
Food Science
Microbiology
Health(social science)
Health Professions (miscellaneous)
Plant Science
SDG 3 - Good Health and Well-being
description Funding Information: Funding: This work was supported by FCT–Fundação para a Ciência e a Tecnologia (grants UIDB/04567/2020 and UIDP/04567/2020 to CBIOS, PTDC/BIA-MOL/31104/2017, and PhD grants 2020.07813.BD to Í.G. and 2020.04630.BD to D.C.). C.F.-P. and R.M. are funded by FCT Scientific Employment Stimulus contract with the reference numbers CEEC/CBIOS/NUT/2018 and CEEC/04567/CBIOS/2020, respectively. Authors also acknowledge COFAC/ILIND–Cooperativa De Formação E Animação Cultural CRL/Instituto Lusófono de Investigação e Desenvolvimento (grant COFAC/ILIND/CBIOS/2/2021). Authors also acknowledge the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme under grant agreement No 804229. iNOVA4Health Research Unit (LISBOA-01-0145-FEDER-007344), which is co-funded by FCT/Ministério da Ciência e do Ensino Superior, through national funds, and by FEDER under the PT2020 Partnership Agreement.
publishDate 2022
dc.date.none.fl_str_mv 2022-05-10T22:47:19Z
2022-04-06
2022-04-06T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/137725
url http://hdl.handle.net/10362/137725
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2304-8158
PURE: 43679127
https://doi.org/10.3390/foods11071060
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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