Supercritical antisolvent precipitation of PHBV microparticles

Detalhes bibliográficos
Autor(a) principal: Costa, M. S.
Data de Publicação: 2007
Outros Autores: Duarte, Ana Rita C., Cardoso, M. M., Duarte, Catarina M. M.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/13424
Resumo: The micronization of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) from organic solutions using supercritical antisolvent (SAS) technique has been successfully achieved. SASexperiments were carried out at different operational conditions and microspheres with mean diameters ranging from 3 to 9 mwere obtained. The effect of CO2 and liquid flow, temperature and pressure on particle size and particle size distribution was evaluated. The microspheres were precipitated from a dichloromethane (DCM) solution. The best process conditions for this mixture were, according to our study, 40 ◦C, 100 bar, 1mLmin−1 liquid flow and 10 L min−1 carbon dioxide flow. Experiments with polymers containing different HV percentages were carried out. The powders obtained became more spherical as the HV content decreased.
id RCAP_e02798fe1eda94a6412886e8aeefccc8
oai_identifier_str oai:repositorium.sdum.uminho.pt:1822/13424
network_acronym_str RCAP
network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str 7160
spelling Supercritical antisolvent precipitation of PHBV microparticlesSupercritical fluidsMicronizationSASNatural polymersPHBVDrug deliveryThe micronization of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) from organic solutions using supercritical antisolvent (SAS) technique has been successfully achieved. SASexperiments were carried out at different operational conditions and microspheres with mean diameters ranging from 3 to 9 mwere obtained. The effect of CO2 and liquid flow, temperature and pressure on particle size and particle size distribution was evaluated. The microspheres were precipitated from a dichloromethane (DCM) solution. The best process conditions for this mixture were, according to our study, 40 ◦C, 100 bar, 1mLmin−1 liquid flow and 10 L min−1 carbon dioxide flow. Experiments with polymers containing different HV percentages were carried out. The powders obtained became more spherical as the HV content decreased.ElsevierUniversidade do MinhoCosta, M. S.Duarte, Ana Rita C.Cardoso, M. M.Duarte, Catarina M. M.20072007-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/13424eng0378-5173info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:41:19Zoai:repositorium.sdum.uminho.pt:1822/13424Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:38:17.211113Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Supercritical antisolvent precipitation of PHBV microparticles
title Supercritical antisolvent precipitation of PHBV microparticles
spellingShingle Supercritical antisolvent precipitation of PHBV microparticles
Costa, M. S.
Supercritical fluids
Micronization
SAS
Natural polymers
PHBV
Drug delivery
title_short Supercritical antisolvent precipitation of PHBV microparticles
title_full Supercritical antisolvent precipitation of PHBV microparticles
title_fullStr Supercritical antisolvent precipitation of PHBV microparticles
title_full_unstemmed Supercritical antisolvent precipitation of PHBV microparticles
title_sort Supercritical antisolvent precipitation of PHBV microparticles
author Costa, M. S.
author_facet Costa, M. S.
Duarte, Ana Rita C.
Cardoso, M. M.
Duarte, Catarina M. M.
author_role author
author2 Duarte, Ana Rita C.
Cardoso, M. M.
Duarte, Catarina M. M.
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Costa, M. S.
Duarte, Ana Rita C.
Cardoso, M. M.
Duarte, Catarina M. M.
dc.subject.por.fl_str_mv Supercritical fluids
Micronization
SAS
Natural polymers
PHBV
Drug delivery
topic Supercritical fluids
Micronization
SAS
Natural polymers
PHBV
Drug delivery
description The micronization of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) from organic solutions using supercritical antisolvent (SAS) technique has been successfully achieved. SASexperiments were carried out at different operational conditions and microspheres with mean diameters ranging from 3 to 9 mwere obtained. The effect of CO2 and liquid flow, temperature and pressure on particle size and particle size distribution was evaluated. The microspheres were precipitated from a dichloromethane (DCM) solution. The best process conditions for this mixture were, according to our study, 40 ◦C, 100 bar, 1mLmin−1 liquid flow and 10 L min−1 carbon dioxide flow. Experiments with polymers containing different HV percentages were carried out. The powders obtained became more spherical as the HV content decreased.
publishDate 2007
dc.date.none.fl_str_mv 2007
2007-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/13424
url http://hdl.handle.net/1822/13424
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0378-5173
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
_version_ 1799132919469441024

Registros relacionados