Lipoarabinomannan in Active and Passive Protection Against Tuberculosis
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/62419 |
Resumo: | Tuberculosis (TB) is considered the most onerous of infectious diseases according to recent reports from the World Health Organization. Available tests for TB diagnosis present severe limitations, and a reliable point-of-care (POC) diagnostic test does not exist. Neither is there a test to discern between the different stages of TB, and in particular to predict which patients with Mycobacterium tuberculosis infection and no clinical signs are more at risk of advancing to overt disease. We here review the usefulness of mycobacterial lipoarabinomannan (LAM) as a diagnostic marker for active and latent TB and, also, aspects of the immune response to LAM relevant to such tests. There is a high potential for urinary LAM-based POC tests for the diagnosis of active TB. Some technical challenges to optimised sensitivity of the test will be detailed. A method to quantify LAM in urine or serum should be further explored as a test of treatment effect. Recent data on the immune response to LAM suggest that markers for host response to LAM should be investigated for a prognostic test to recognise individuals at the greatest risk of disease activation. |
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Lipoarabinomannan in Active and Passive Protection Against TuberculosislipoarabinomannantuberculosisMycobacteriumglycolipidantibodiesmonoclonalvaccineimmune responseCiências Médicas::Medicina BásicaScience & TechnologyTuberculosis (TB) is considered the most onerous of infectious diseases according to recent reports from the World Health Organization. Available tests for TB diagnosis present severe limitations, and a reliable point-of-care (POC) diagnostic test does not exist. Neither is there a test to discern between the different stages of TB, and in particular to predict which patients with Mycobacterium tuberculosis infection and no clinical signs are more at risk of advancing to overt disease. We here review the usefulness of mycobacterial lipoarabinomannan (LAM) as a diagnostic marker for active and latent TB and, also, aspects of the immune response to LAM relevant to such tests. There is a high potential for urinary LAM-based POC tests for the diagnosis of active TB. Some technical challenges to optimised sensitivity of the test will be detailed. A method to quantify LAM in urine or serum should be further explored as a test of treatment effect. Recent data on the immune response to LAM suggest that markers for host response to LAM should be investigated for a prognostic test to recognise individuals at the greatest risk of disease activation.Swedish Research Council (2016-05683) and the Swedish Heart-Lung Foundation (20180386)Frontiers MediaUniversidade do MinhoCorreia-Neves, MSundling, ChristopherCooper, AndreaKällenius, Gunilla2019-022019-02-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/62419engCorreia-Neves, M., Sundling, C., Cooper, A., & Källenius, G. (2019). Lipoarabinomannan in Active and Passive Protection Against Tuberculosis. Frontiers in immunology, 10.1664-32241664-322410.3389/fimmu.2019.0196831572351https://www.frontiersin.org/articles/10.3389/fimmu.2019.01968/fullinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T11:57:13Zoai:repositorium.sdum.uminho.pt:1822/62419Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:46:52.009747Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Lipoarabinomannan in Active and Passive Protection Against Tuberculosis |
title |
Lipoarabinomannan in Active and Passive Protection Against Tuberculosis |
spellingShingle |
Lipoarabinomannan in Active and Passive Protection Against Tuberculosis Correia-Neves, M lipoarabinomannan tuberculosis Mycobacterium glycolipid antibodies monoclonal vaccine immune response Ciências Médicas::Medicina Básica Science & Technology |
title_short |
Lipoarabinomannan in Active and Passive Protection Against Tuberculosis |
title_full |
Lipoarabinomannan in Active and Passive Protection Against Tuberculosis |
title_fullStr |
Lipoarabinomannan in Active and Passive Protection Against Tuberculosis |
title_full_unstemmed |
Lipoarabinomannan in Active and Passive Protection Against Tuberculosis |
title_sort |
Lipoarabinomannan in Active and Passive Protection Against Tuberculosis |
author |
Correia-Neves, M |
author_facet |
Correia-Neves, M Sundling, Christopher Cooper, Andrea Källenius, Gunilla |
author_role |
author |
author2 |
Sundling, Christopher Cooper, Andrea Källenius, Gunilla |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Correia-Neves, M Sundling, Christopher Cooper, Andrea Källenius, Gunilla |
dc.subject.por.fl_str_mv |
lipoarabinomannan tuberculosis Mycobacterium glycolipid antibodies monoclonal vaccine immune response Ciências Médicas::Medicina Básica Science & Technology |
topic |
lipoarabinomannan tuberculosis Mycobacterium glycolipid antibodies monoclonal vaccine immune response Ciências Médicas::Medicina Básica Science & Technology |
description |
Tuberculosis (TB) is considered the most onerous of infectious diseases according to recent reports from the World Health Organization. Available tests for TB diagnosis present severe limitations, and a reliable point-of-care (POC) diagnostic test does not exist. Neither is there a test to discern between the different stages of TB, and in particular to predict which patients with Mycobacterium tuberculosis infection and no clinical signs are more at risk of advancing to overt disease. We here review the usefulness of mycobacterial lipoarabinomannan (LAM) as a diagnostic marker for active and latent TB and, also, aspects of the immune response to LAM relevant to such tests. There is a high potential for urinary LAM-based POC tests for the diagnosis of active TB. Some technical challenges to optimised sensitivity of the test will be detailed. A method to quantify LAM in urine or serum should be further explored as a test of treatment effect. Recent data on the immune response to LAM suggest that markers for host response to LAM should be investigated for a prognostic test to recognise individuals at the greatest risk of disease activation. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-02 2019-02-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/62419 |
url |
http://hdl.handle.net/1822/62419 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Correia-Neves, M., Sundling, C., Cooper, A., & Källenius, G. (2019). Lipoarabinomannan in Active and Passive Protection Against Tuberculosis. Frontiers in immunology, 10. 1664-3224 1664-3224 10.3389/fimmu.2019.01968 31572351 https://www.frontiersin.org/articles/10.3389/fimmu.2019.01968/full |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Frontiers Media |
publisher.none.fl_str_mv |
Frontiers Media |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799132225556447232 |