All you need to know about sperm RNAs

Detalhes bibliográficos
Autor(a) principal: Santiago, Joana
Data de Publicação: 2021
Outros Autores: Silva, Joana V., Howl, John, Santos, Manuel A. S., Fardilha, Margarida
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10773/40019
Resumo: Spermatogenesis generates a small and highly specialised type of cell that is apparently incapable of transcription and translation. For many years, this dogma was supported by the assumption that (i) the compact sperm nucleus, resulting from the substitution of histones by protamine during spermatogenesis, renders the genome inaccessible to the transcriptional machinery; and (ii) the loss of most organelles, including endoplasmic reticulum and ribosomes, limits or prevents translational activity. Despite these observations, several types of coding and non-coding RNAs have been identified in human sperm. Their functional roles, particularly during fertilisation and embryonic development, are only now becoming apparent.
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spelling All you need to know about sperm RNAsEmbryo developmentEpigeneticsFertilisationMale infertilityRNASpermatozoaTranscriptomeSpermatogenesis generates a small and highly specialised type of cell that is apparently incapable of transcription and translation. For many years, this dogma was supported by the assumption that (i) the compact sperm nucleus, resulting from the substitution of histones by protamine during spermatogenesis, renders the genome inaccessible to the transcriptional machinery; and (ii) the loss of most organelles, including endoplasmic reticulum and ribosomes, limits or prevents translational activity. Despite these observations, several types of coding and non-coding RNAs have been identified in human sperm. Their functional roles, particularly during fertilisation and embryonic development, are only now becoming apparent.Oxford University Press2024-01-09T12:41:52Z2021-01-01T00:00:00Z2021-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10773/40019eng1355-478610.1093/humupd/dmab034Santiago, JoanaSilva, Joana V.Howl, JohnSantos, Manuel A. S.Fardilha, Margaridainfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-02-22T12:18:12Zoai:ria.ua.pt:10773/40019Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:10:03.693968Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv All you need to know about sperm RNAs
title All you need to know about sperm RNAs
spellingShingle All you need to know about sperm RNAs
Santiago, Joana
Embryo development
Epigenetics
Fertilisation
Male infertility
RNA
Spermatozoa
Transcriptome
title_short All you need to know about sperm RNAs
title_full All you need to know about sperm RNAs
title_fullStr All you need to know about sperm RNAs
title_full_unstemmed All you need to know about sperm RNAs
title_sort All you need to know about sperm RNAs
author Santiago, Joana
author_facet Santiago, Joana
Silva, Joana V.
Howl, John
Santos, Manuel A. S.
Fardilha, Margarida
author_role author
author2 Silva, Joana V.
Howl, John
Santos, Manuel A. S.
Fardilha, Margarida
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Santiago, Joana
Silva, Joana V.
Howl, John
Santos, Manuel A. S.
Fardilha, Margarida
dc.subject.por.fl_str_mv Embryo development
Epigenetics
Fertilisation
Male infertility
RNA
Spermatozoa
Transcriptome
topic Embryo development
Epigenetics
Fertilisation
Male infertility
RNA
Spermatozoa
Transcriptome
description Spermatogenesis generates a small and highly specialised type of cell that is apparently incapable of transcription and translation. For many years, this dogma was supported by the assumption that (i) the compact sperm nucleus, resulting from the substitution of histones by protamine during spermatogenesis, renders the genome inaccessible to the transcriptional machinery; and (ii) the loss of most organelles, including endoplasmic reticulum and ribosomes, limits or prevents translational activity. Despite these observations, several types of coding and non-coding RNAs have been identified in human sperm. Their functional roles, particularly during fertilisation and embryonic development, are only now becoming apparent.
publishDate 2021
dc.date.none.fl_str_mv 2021-01-01T00:00:00Z
2021-01-01
2024-01-09T12:41:52Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10773/40019
url http://hdl.handle.net/10773/40019
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1355-4786
10.1093/humupd/dmab034
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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