Functional network resilience to pathology in presymptomatic genetic frontotemporal dementia

Detalhes bibliográficos
Autor(a) principal: Rittman, Timothy
Data de Publicação: 2019
Outros Autores: Borchert, Robin, Jones, Simon, van Swieten, John, Borroni, Barbara, Galimberti, Daniela, Masellis, Mario, Tartaglia, Maria Carmela, Graff, Caroline, Tagliavini, Fabrizio, Frisoni, Giovanni B., Santiago, Beatriz, Scarpini, Elio, Schönecker, Sonja, Semler, Elisa, Shafei, Rachelle, Shoesmith, Christen, Tábuas-Pereira, Miguel, Tainta, Mikel, Taipa, Ricardo, Tang-Wai, David, Laforce, Robert, Thomas, David L., Thonberg, Hakan, Timberlake, Carolyn, Tiraboschi, Pietro, Vandamme, Philip, Vandenbulcke, Mathieu, Veldsman, Michele, Verdelho, Ana, Villanua, Jorge, Warren, Jason, Finger, Elizabeth, Wilke, Carlo, Woollacott, Ione, Wlasich, Elisabeth, Zetterberg, Henrik, Zulaica, Miren, De Mendonça, Alexandre, Sorbi, Sandro, Rohrer, Jonathan D., Rowe, James B., Afonso, Sónia, Almeida, Maria Rosario, Anderl-Straub, Sarah, Andersson, Christin, Antonell, Anna, Archetti, Silvana, Arighi, Andrea, Balasa, Mircea, Barandiaran, Myriam, Bargalló, Nuria, Bartha, Robart, Bender, Benjamin, Benussi, Luisa, Bessi, Valentina, Binetti, Giuliano, Black, Sandra, Bocchetta, Martina, Borrego-Ecija, Sergi, Bras, Jose, Bruffaerts, Rose, Caroppo, Paola, Cash, David, Castelo-Branco, Miguel, Convery, Rhian, Cope, Thomas, Cosseddu, Maura, de Arriba, María, Di Fede, Giuseppe, Díaz, Zigor, Dick, Katrina M., Duro, Diana, Fenoglio, Chiara, Ferrari, Camilla, Ferreira, Catarina B., Flanagana, Toby, Fox, Nick, Freedman, Morris, Fumagalli, Giorgio, Gabilondo, Alazne, Gasparotti, Roberto, Gauthier, Serge, Gazzina, Stefano, Ghidoni, Roberta, Giaccone, Giorgio, Gorostidi, Ana, Greaves, Caroline, Guerreiro, Rita, Heller, Carolin, Hoegen, Tobias, Indakoetxea, Begoña, Jelic, Vesna, Jiskoot, Lize, Karnath, Hans-Otto, Keren, Ron, Leitão, Maria João, Lladó, Albert, Lombardi, Gemma, Loosli, Sandra, Maruta, Carolina, Mead, Simon, Meeter, Lieke, Miltenberger-Miltenyi, Gabriel, van Minkelen, Rick, Mitchell, Sara, Nacmias, Benedetta, Neason, Mollie, Nicholas, Jennifer, Öijerstedt, Linn, Olives, Jaume, Padovani, Alessandro, Panman, Jessica, Papma, Janne, Pievani, Michela, Pijnenburg, Yolande, Premi, Enrico, Prioni, Sara, Prix, Catharina, Rademakers, Rosa, Redaelli, Veronica, Rogaeva, Ekaterina, Rosa-Neto, Pedro, Rossi, Giacomina, Rosser, Martin
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/52792
Resumo: © 2019 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)
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spelling Functional network resilience to pathology in presymptomatic genetic frontotemporal dementiaCognitionConnectivityFrontotemporal dementiaFunctional imagingGenetics© 2019 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)The presymptomatic phase of neurodegenerative diseases are characterized by structural brain changes without significant clinical features. We set out to investigate the contribution of functional network resilience to preserved cognition in presymptomatic genetic frontotemporal dementia. We studied 172 people from families carrying genetic abnormalities in C9orf72, MAPT, or PGRN. Networks were extracted from functional MRI data and assessed using graph theoretical analysis. We found that despite loss of both brain volume and functional connections, there is maintenance of an efficient topological organization of the brain's functional network in the years leading up to the estimated age of frontotemporal dementia symptom onset. After this point, functional network efficiency declines markedly. Reduction in connectedness was most marked in highly connected hub regions. Measures of topological efficiency of the brain's functional network and organization predicted cognitive dysfunction in domains related to symptomatic frontotemporal dementia and connectivity correlated with brain volume loss in frontotemporal dementia. We propose that maintaining the efficient organization of the brain's functional network supports cognitive health even as atrophy and connectivity decline presymptomatically.This work was funded by the UK Medical Research Council, the Italian Ministry of Health, and the Canadian Institutes of Health Research as part of a Centres of Excellence in Neurodegeneration grant [grant number CoEN015]. JBR was supported by the Wellcome Trust [grant number 103838]. JBR, RB, TR, and SJ were supported by the NIHR Cambridge Biomedical Research Centre and Medical Research Council [grant number G1100464]. The Dementia Research Centre at UCL is supported by Alzheimer's Research UK, Brain Research Trust, and The Wolfson Foundation, NIHR Queen Square Dementia Biomedical Research Unit, NIHR UCL/H Biomedical Research Centre and Dementia Platforms UK. JDR is supported by an MRC Clinician Scientist Fellowship [grant number MR/M008525/1] and has received funding from the NIHR Rare Disease Translational Research Collaboration [grant number BRC149/NS/MH]. MM is supported by the Canadian Institutes of Health Research, Department of Medicine at Sunnybrook Health Sciences Centre and the University of Toronto, and the Sunnybrook Research Institute. RL is supported by Réseau de médecine génétique appliquée, Fonds de recherche du Québec—Santé [grant number FRQS]. FT is supported by the Italian Ministry of Health. DG is supported by the Fondazione Monzino and Italian Ministry of Health, Ricerca Corrente. SS is supported by Cassa di Risparmio di Firenze [grant number CRF 2013/0199] and the Ministry of Health [grant number RF-2010-2319722]. JvS is supported by The Netherlands Organisation for Health Research and Development Memorable grant [grant number 733050103] and Netherlands Alzheimer Foundation Memorable grant [grant number 733050103].ElsevierRepositório da Universidade de LisboaRittman, TimothyBorchert, RobinJones, Simonvan Swieten, JohnBorroni, BarbaraGalimberti, DanielaMasellis, MarioTartaglia, Maria CarmelaGraff, CarolineTagliavini, FabrizioFrisoni, Giovanni B.Santiago, BeatrizScarpini, ElioSchönecker, SonjaSemler, ElisaShafei, RachelleShoesmith, ChristenTábuas-Pereira, MiguelTainta, MikelTaipa, RicardoTang-Wai, DavidLaforce, RobertThomas, David L.Thonberg, HakanTimberlake, CarolynTiraboschi, PietroVandamme, PhilipVandenbulcke, MathieuVeldsman, MicheleVerdelho, AnaVillanua, JorgeWarren, JasonFinger, ElizabethWilke, CarloWoollacott, IoneWlasich, ElisabethZetterberg, HenrikZulaica, MirenDe Mendonça, AlexandreSorbi, SandroRohrer, Jonathan D.Rowe, James B.Afonso, SóniaAlmeida, Maria RosarioAnderl-Straub, SarahAndersson, ChristinAntonell, AnnaArchetti, SilvanaArighi, AndreaBalasa, MirceaBarandiaran, MyriamBargalló, NuriaBartha, RobartBender, BenjaminBenussi, LuisaBessi, ValentinaBinetti, GiulianoBlack, SandraBocchetta, MartinaBorrego-Ecija, SergiBras, JoseBruffaerts, RoseCaroppo, PaolaCash, DavidCastelo-Branco, MiguelConvery, RhianCope, ThomasCosseddu, Maurade Arriba, MaríaDi Fede, GiuseppeDíaz, ZigorDick, Katrina M.Duro, DianaFenoglio, ChiaraFerrari, CamillaFerreira, Catarina B.Flanagana, TobyFox, NickFreedman, MorrisFumagalli, GiorgioGabilondo, AlazneGasparotti, RobertoGauthier, SergeGazzina, StefanoGhidoni, RobertaGiaccone, GiorgioGorostidi, AnaGreaves, CarolineGuerreiro, RitaHeller, CarolinHoegen, TobiasIndakoetxea, BegoñaJelic, VesnaJiskoot, LizeKarnath, Hans-OttoKeren, RonLeitão, Maria JoãoLladó, AlbertLombardi, GemmaLoosli, SandraMaruta, CarolinaMead, SimonMeeter, LiekeMiltenberger-Miltenyi, Gabrielvan Minkelen, RickMitchell, SaraNacmias, BenedettaNeason, MollieNicholas, JenniferÖijerstedt, LinnOlives, JaumePadovani, AlessandroPanman, JessicaPapma, JannePievani, MichelaPijnenburg, YolandePremi, EnricoPrioni, SaraPrix, CatharinaRademakers, RosaRedaelli, VeronicaRogaeva, EkaterinaRosa-Neto, PedroRossi, GiacominaRosser, Martin2022-05-09T11:41:06Z20192019-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/52792engNeurobiol Aging. 2019 May;77:169-1770197-458010.1016/j.neurobiolaging.2018.12.0091558-1497info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:58:11Zoai:repositorio.ul.pt:10451/52792Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:03:48.425339Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Functional network resilience to pathology in presymptomatic genetic frontotemporal dementia
title Functional network resilience to pathology in presymptomatic genetic frontotemporal dementia
spellingShingle Functional network resilience to pathology in presymptomatic genetic frontotemporal dementia
Rittman, Timothy
Cognition
Connectivity
Frontotemporal dementia
Functional imaging
Genetics
title_short Functional network resilience to pathology in presymptomatic genetic frontotemporal dementia
title_full Functional network resilience to pathology in presymptomatic genetic frontotemporal dementia
title_fullStr Functional network resilience to pathology in presymptomatic genetic frontotemporal dementia
title_full_unstemmed Functional network resilience to pathology in presymptomatic genetic frontotemporal dementia
title_sort Functional network resilience to pathology in presymptomatic genetic frontotemporal dementia
author Rittman, Timothy
author_facet Rittman, Timothy
Borchert, Robin
Jones, Simon
van Swieten, John
Borroni, Barbara
Galimberti, Daniela
Masellis, Mario
Tartaglia, Maria Carmela
Graff, Caroline
Tagliavini, Fabrizio
Frisoni, Giovanni B.
Santiago, Beatriz
Scarpini, Elio
Schönecker, Sonja
Semler, Elisa
Shafei, Rachelle
Shoesmith, Christen
Tábuas-Pereira, Miguel
Tainta, Mikel
Taipa, Ricardo
Tang-Wai, David
Laforce, Robert
Thomas, David L.
Thonberg, Hakan
Timberlake, Carolyn
Tiraboschi, Pietro
Vandamme, Philip
Vandenbulcke, Mathieu
Veldsman, Michele
Verdelho, Ana
Villanua, Jorge
Warren, Jason
Finger, Elizabeth
Wilke, Carlo
Woollacott, Ione
Wlasich, Elisabeth
Zetterberg, Henrik
Zulaica, Miren
De Mendonça, Alexandre
Sorbi, Sandro
Rohrer, Jonathan D.
Rowe, James B.
Afonso, Sónia
Almeida, Maria Rosario
Anderl-Straub, Sarah
Andersson, Christin
Antonell, Anna
Archetti, Silvana
Arighi, Andrea
Balasa, Mircea
Barandiaran, Myriam
Bargalló, Nuria
Bartha, Robart
Bender, Benjamin
Benussi, Luisa
Bessi, Valentina
Binetti, Giuliano
Black, Sandra
Bocchetta, Martina
Borrego-Ecija, Sergi
Bras, Jose
Bruffaerts, Rose
Caroppo, Paola
Cash, David
Castelo-Branco, Miguel
Convery, Rhian
Cope, Thomas
Cosseddu, Maura
de Arriba, María
Di Fede, Giuseppe
Díaz, Zigor
Dick, Katrina M.
Duro, Diana
Fenoglio, Chiara
Ferrari, Camilla
Ferreira, Catarina B.
Flanagana, Toby
Fox, Nick
Freedman, Morris
Fumagalli, Giorgio
Gabilondo, Alazne
Gasparotti, Roberto
Gauthier, Serge
Gazzina, Stefano
Ghidoni, Roberta
Giaccone, Giorgio
Gorostidi, Ana
Greaves, Caroline
Guerreiro, Rita
Heller, Carolin
Hoegen, Tobias
Indakoetxea, Begoña
Jelic, Vesna
Jiskoot, Lize
Karnath, Hans-Otto
Keren, Ron
Leitão, Maria João
Lladó, Albert
Lombardi, Gemma
Loosli, Sandra
Maruta, Carolina
Mead, Simon
Meeter, Lieke
Miltenberger-Miltenyi, Gabriel
van Minkelen, Rick
Mitchell, Sara
Nacmias, Benedetta
Neason, Mollie
Nicholas, Jennifer
Öijerstedt, Linn
Olives, Jaume
Padovani, Alessandro
Panman, Jessica
Papma, Janne
Pievani, Michela
Pijnenburg, Yolande
Premi, Enrico
Prioni, Sara
Prix, Catharina
Rademakers, Rosa
Redaelli, Veronica
Rogaeva, Ekaterina
Rosa-Neto, Pedro
Rossi, Giacomina
Rosser, Martin
author_role author
author2 Borchert, Robin
Jones, Simon
van Swieten, John
Borroni, Barbara
Galimberti, Daniela
Masellis, Mario
Tartaglia, Maria Carmela
Graff, Caroline
Tagliavini, Fabrizio
Frisoni, Giovanni B.
Santiago, Beatriz
Scarpini, Elio
Schönecker, Sonja
Semler, Elisa
Shafei, Rachelle
Shoesmith, Christen
Tábuas-Pereira, Miguel
Tainta, Mikel
Taipa, Ricardo
Tang-Wai, David
Laforce, Robert
Thomas, David L.
Thonberg, Hakan
Timberlake, Carolyn
Tiraboschi, Pietro
Vandamme, Philip
Vandenbulcke, Mathieu
Veldsman, Michele
Verdelho, Ana
Villanua, Jorge
Warren, Jason
Finger, Elizabeth
Wilke, Carlo
Woollacott, Ione
Wlasich, Elisabeth
Zetterberg, Henrik
Zulaica, Miren
De Mendonça, Alexandre
Sorbi, Sandro
Rohrer, Jonathan D.
Rowe, James B.
Afonso, Sónia
Almeida, Maria Rosario
Anderl-Straub, Sarah
Andersson, Christin
Antonell, Anna
Archetti, Silvana
Arighi, Andrea
Balasa, Mircea
Barandiaran, Myriam
Bargalló, Nuria
Bartha, Robart
Bender, Benjamin
Benussi, Luisa
Bessi, Valentina
Binetti, Giuliano
Black, Sandra
Bocchetta, Martina
Borrego-Ecija, Sergi
Bras, Jose
Bruffaerts, Rose
Caroppo, Paola
Cash, David
Castelo-Branco, Miguel
Convery, Rhian
Cope, Thomas
Cosseddu, Maura
de Arriba, María
Di Fede, Giuseppe
Díaz, Zigor
Dick, Katrina M.
Duro, Diana
Fenoglio, Chiara
Ferrari, Camilla
Ferreira, Catarina B.
Flanagana, Toby
Fox, Nick
Freedman, Morris
Fumagalli, Giorgio
Gabilondo, Alazne
Gasparotti, Roberto
Gauthier, Serge
Gazzina, Stefano
Ghidoni, Roberta
Giaccone, Giorgio
Gorostidi, Ana
Greaves, Caroline
Guerreiro, Rita
Heller, Carolin
Hoegen, Tobias
Indakoetxea, Begoña
Jelic, Vesna
Jiskoot, Lize
Karnath, Hans-Otto
Keren, Ron
Leitão, Maria João
Lladó, Albert
Lombardi, Gemma
Loosli, Sandra
Maruta, Carolina
Mead, Simon
Meeter, Lieke
Miltenberger-Miltenyi, Gabriel
van Minkelen, Rick
Mitchell, Sara
Nacmias, Benedetta
Neason, Mollie
Nicholas, Jennifer
Öijerstedt, Linn
Olives, Jaume
Padovani, Alessandro
Panman, Jessica
Papma, Janne
Pievani, Michela
Pijnenburg, Yolande
Premi, Enrico
Prioni, Sara
Prix, Catharina
Rademakers, Rosa
Redaelli, Veronica
Rogaeva, Ekaterina
Rosa-Neto, Pedro
Rossi, Giacomina
Rosser, Martin
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dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Rittman, Timothy
Borchert, Robin
Jones, Simon
van Swieten, John
Borroni, Barbara
Galimberti, Daniela
Masellis, Mario
Tartaglia, Maria Carmela
Graff, Caroline
Tagliavini, Fabrizio
Frisoni, Giovanni B.
Santiago, Beatriz
Scarpini, Elio
Schönecker, Sonja
Semler, Elisa
Shafei, Rachelle
Shoesmith, Christen
Tábuas-Pereira, Miguel
Tainta, Mikel
Taipa, Ricardo
Tang-Wai, David
Laforce, Robert
Thomas, David L.
Thonberg, Hakan
Timberlake, Carolyn
Tiraboschi, Pietro
Vandamme, Philip
Vandenbulcke, Mathieu
Veldsman, Michele
Verdelho, Ana
Villanua, Jorge
Warren, Jason
Finger, Elizabeth
Wilke, Carlo
Woollacott, Ione
Wlasich, Elisabeth
Zetterberg, Henrik
Zulaica, Miren
De Mendonça, Alexandre
Sorbi, Sandro
Rohrer, Jonathan D.
Rowe, James B.
Afonso, Sónia
Almeida, Maria Rosario
Anderl-Straub, Sarah
Andersson, Christin
Antonell, Anna
Archetti, Silvana
Arighi, Andrea
Balasa, Mircea
Barandiaran, Myriam
Bargalló, Nuria
Bartha, Robart
Bender, Benjamin
Benussi, Luisa
Bessi, Valentina
Binetti, Giuliano
Black, Sandra
Bocchetta, Martina
Borrego-Ecija, Sergi
Bras, Jose
Bruffaerts, Rose
Caroppo, Paola
Cash, David
Castelo-Branco, Miguel
Convery, Rhian
Cope, Thomas
Cosseddu, Maura
de Arriba, María
Di Fede, Giuseppe
Díaz, Zigor
Dick, Katrina M.
Duro, Diana
Fenoglio, Chiara
Ferrari, Camilla
Ferreira, Catarina B.
Flanagana, Toby
Fox, Nick
Freedman, Morris
Fumagalli, Giorgio
Gabilondo, Alazne
Gasparotti, Roberto
Gauthier, Serge
Gazzina, Stefano
Ghidoni, Roberta
Giaccone, Giorgio
Gorostidi, Ana
Greaves, Caroline
Guerreiro, Rita
Heller, Carolin
Hoegen, Tobias
Indakoetxea, Begoña
Jelic, Vesna
Jiskoot, Lize
Karnath, Hans-Otto
Keren, Ron
Leitão, Maria João
Lladó, Albert
Lombardi, Gemma
Loosli, Sandra
Maruta, Carolina
Mead, Simon
Meeter, Lieke
Miltenberger-Miltenyi, Gabriel
van Minkelen, Rick
Mitchell, Sara
Nacmias, Benedetta
Neason, Mollie
Nicholas, Jennifer
Öijerstedt, Linn
Olives, Jaume
Padovani, Alessandro
Panman, Jessica
Papma, Janne
Pievani, Michela
Pijnenburg, Yolande
Premi, Enrico
Prioni, Sara
Prix, Catharina
Rademakers, Rosa
Redaelli, Veronica
Rogaeva, Ekaterina
Rosa-Neto, Pedro
Rossi, Giacomina
Rosser, Martin
dc.subject.por.fl_str_mv Cognition
Connectivity
Frontotemporal dementia
Functional imaging
Genetics
topic Cognition
Connectivity
Frontotemporal dementia
Functional imaging
Genetics
description © 2019 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)
publishDate 2019
dc.date.none.fl_str_mv 2019
2019-01-01T00:00:00Z
2022-05-09T11:41:06Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/52792
url http://hdl.handle.net/10451/52792
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Neurobiol Aging. 2019 May;77:169-177
0197-4580
10.1016/j.neurobiolaging.2018.12.009
1558-1497
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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