Functional network resilience to pathology in presymptomatic genetic frontotemporal dementia
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10451/52792 |
Resumo: | © 2019 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/) |
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Functional network resilience to pathology in presymptomatic genetic frontotemporal dementiaCognitionConnectivityFrontotemporal dementiaFunctional imagingGenetics© 2019 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)The presymptomatic phase of neurodegenerative diseases are characterized by structural brain changes without significant clinical features. We set out to investigate the contribution of functional network resilience to preserved cognition in presymptomatic genetic frontotemporal dementia. We studied 172 people from families carrying genetic abnormalities in C9orf72, MAPT, or PGRN. Networks were extracted from functional MRI data and assessed using graph theoretical analysis. We found that despite loss of both brain volume and functional connections, there is maintenance of an efficient topological organization of the brain's functional network in the years leading up to the estimated age of frontotemporal dementia symptom onset. After this point, functional network efficiency declines markedly. Reduction in connectedness was most marked in highly connected hub regions. Measures of topological efficiency of the brain's functional network and organization predicted cognitive dysfunction in domains related to symptomatic frontotemporal dementia and connectivity correlated with brain volume loss in frontotemporal dementia. We propose that maintaining the efficient organization of the brain's functional network supports cognitive health even as atrophy and connectivity decline presymptomatically.This work was funded by the UK Medical Research Council, the Italian Ministry of Health, and the Canadian Institutes of Health Research as part of a Centres of Excellence in Neurodegeneration grant [grant number CoEN015]. JBR was supported by the Wellcome Trust [grant number 103838]. JBR, RB, TR, and SJ were supported by the NIHR Cambridge Biomedical Research Centre and Medical Research Council [grant number G1100464]. The Dementia Research Centre at UCL is supported by Alzheimer's Research UK, Brain Research Trust, and The Wolfson Foundation, NIHR Queen Square Dementia Biomedical Research Unit, NIHR UCL/H Biomedical Research Centre and Dementia Platforms UK. JDR is supported by an MRC Clinician Scientist Fellowship [grant number MR/M008525/1] and has received funding from the NIHR Rare Disease Translational Research Collaboration [grant number BRC149/NS/MH]. MM is supported by the Canadian Institutes of Health Research, Department of Medicine at Sunnybrook Health Sciences Centre and the University of Toronto, and the Sunnybrook Research Institute. RL is supported by Réseau de médecine génétique appliquée, Fonds de recherche du Québec—Santé [grant number FRQS]. FT is supported by the Italian Ministry of Health. DG is supported by the Fondazione Monzino and Italian Ministry of Health, Ricerca Corrente. SS is supported by Cassa di Risparmio di Firenze [grant number CRF 2013/0199] and the Ministry of Health [grant number RF-2010-2319722]. JvS is supported by The Netherlands Organisation for Health Research and Development Memorable grant [grant number 733050103] and Netherlands Alzheimer Foundation Memorable grant [grant number 733050103].ElsevierRepositório da Universidade de LisboaRittman, TimothyBorchert, RobinJones, Simonvan Swieten, JohnBorroni, BarbaraGalimberti, DanielaMasellis, MarioTartaglia, Maria CarmelaGraff, CarolineTagliavini, FabrizioFrisoni, Giovanni B.Santiago, BeatrizScarpini, ElioSchönecker, SonjaSemler, ElisaShafei, RachelleShoesmith, ChristenTábuas-Pereira, MiguelTainta, MikelTaipa, RicardoTang-Wai, DavidLaforce, RobertThomas, David L.Thonberg, HakanTimberlake, CarolynTiraboschi, PietroVandamme, PhilipVandenbulcke, MathieuVeldsman, MicheleVerdelho, AnaVillanua, JorgeWarren, JasonFinger, ElizabethWilke, CarloWoollacott, IoneWlasich, ElisabethZetterberg, HenrikZulaica, MirenDe Mendonça, AlexandreSorbi, SandroRohrer, Jonathan D.Rowe, James B.Afonso, SóniaAlmeida, Maria RosarioAnderl-Straub, SarahAndersson, ChristinAntonell, AnnaArchetti, SilvanaArighi, AndreaBalasa, MirceaBarandiaran, MyriamBargalló, NuriaBartha, RobartBender, BenjaminBenussi, LuisaBessi, ValentinaBinetti, GiulianoBlack, SandraBocchetta, MartinaBorrego-Ecija, SergiBras, JoseBruffaerts, RoseCaroppo, PaolaCash, DavidCastelo-Branco, MiguelConvery, RhianCope, ThomasCosseddu, Maurade Arriba, MaríaDi Fede, GiuseppeDíaz, ZigorDick, Katrina M.Duro, DianaFenoglio, ChiaraFerrari, CamillaFerreira, Catarina B.Flanagana, TobyFox, NickFreedman, MorrisFumagalli, GiorgioGabilondo, AlazneGasparotti, RobertoGauthier, SergeGazzina, StefanoGhidoni, RobertaGiaccone, GiorgioGorostidi, AnaGreaves, CarolineGuerreiro, RitaHeller, CarolinHoegen, TobiasIndakoetxea, BegoñaJelic, VesnaJiskoot, LizeKarnath, Hans-OttoKeren, RonLeitão, Maria JoãoLladó, AlbertLombardi, GemmaLoosli, SandraMaruta, CarolinaMead, SimonMeeter, LiekeMiltenberger-Miltenyi, Gabrielvan Minkelen, RickMitchell, SaraNacmias, BenedettaNeason, MollieNicholas, JenniferÖijerstedt, LinnOlives, JaumePadovani, AlessandroPanman, JessicaPapma, JannePievani, MichelaPijnenburg, YolandePremi, EnricoPrioni, SaraPrix, CatharinaRademakers, RosaRedaelli, VeronicaRogaeva, EkaterinaRosa-Neto, PedroRossi, GiacominaRosser, Martin2022-05-09T11:41:06Z20192019-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/52792engNeurobiol Aging. 2019 May;77:169-1770197-458010.1016/j.neurobiolaging.2018.12.0091558-1497info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:58:11Zoai:repositorio.ul.pt:10451/52792Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:03:48.425339Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Functional network resilience to pathology in presymptomatic genetic frontotemporal dementia |
title |
Functional network resilience to pathology in presymptomatic genetic frontotemporal dementia |
spellingShingle |
Functional network resilience to pathology in presymptomatic genetic frontotemporal dementia Rittman, Timothy Cognition Connectivity Frontotemporal dementia Functional imaging Genetics |
title_short |
Functional network resilience to pathology in presymptomatic genetic frontotemporal dementia |
title_full |
Functional network resilience to pathology in presymptomatic genetic frontotemporal dementia |
title_fullStr |
Functional network resilience to pathology in presymptomatic genetic frontotemporal dementia |
title_full_unstemmed |
Functional network resilience to pathology in presymptomatic genetic frontotemporal dementia |
title_sort |
Functional network resilience to pathology in presymptomatic genetic frontotemporal dementia |
author |
Rittman, Timothy |
author_facet |
Rittman, Timothy Borchert, Robin Jones, Simon van Swieten, John Borroni, Barbara Galimberti, Daniela Masellis, Mario Tartaglia, Maria Carmela Graff, Caroline Tagliavini, Fabrizio Frisoni, Giovanni B. Santiago, Beatriz Scarpini, Elio Schönecker, Sonja Semler, Elisa Shafei, Rachelle Shoesmith, Christen Tábuas-Pereira, Miguel Tainta, Mikel Taipa, Ricardo Tang-Wai, David Laforce, Robert Thomas, David L. Thonberg, Hakan Timberlake, Carolyn Tiraboschi, Pietro Vandamme, Philip Vandenbulcke, Mathieu Veldsman, Michele Verdelho, Ana Villanua, Jorge Warren, Jason Finger, Elizabeth Wilke, Carlo Woollacott, Ione Wlasich, Elisabeth Zetterberg, Henrik Zulaica, Miren De Mendonça, Alexandre Sorbi, Sandro Rohrer, Jonathan D. Rowe, James B. Afonso, Sónia Almeida, Maria Rosario Anderl-Straub, Sarah Andersson, Christin Antonell, Anna Archetti, Silvana Arighi, Andrea Balasa, Mircea Barandiaran, Myriam Bargalló, Nuria Bartha, Robart Bender, Benjamin Benussi, Luisa Bessi, Valentina Binetti, Giuliano Black, Sandra Bocchetta, Martina Borrego-Ecija, Sergi Bras, Jose Bruffaerts, Rose Caroppo, Paola Cash, David Castelo-Branco, Miguel Convery, Rhian Cope, Thomas Cosseddu, Maura de Arriba, María Di Fede, Giuseppe Díaz, Zigor Dick, Katrina M. Duro, Diana Fenoglio, Chiara Ferrari, Camilla Ferreira, Catarina B. Flanagana, Toby Fox, Nick Freedman, Morris Fumagalli, Giorgio Gabilondo, Alazne Gasparotti, Roberto Gauthier, Serge Gazzina, Stefano Ghidoni, Roberta Giaccone, Giorgio Gorostidi, Ana Greaves, Caroline Guerreiro, Rita Heller, Carolin Hoegen, Tobias Indakoetxea, Begoña Jelic, Vesna Jiskoot, Lize Karnath, Hans-Otto Keren, Ron Leitão, Maria João Lladó, Albert Lombardi, Gemma Loosli, Sandra Maruta, Carolina Mead, Simon Meeter, Lieke Miltenberger-Miltenyi, Gabriel van Minkelen, Rick Mitchell, Sara Nacmias, Benedetta Neason, Mollie Nicholas, Jennifer Öijerstedt, Linn Olives, Jaume Padovani, Alessandro Panman, Jessica Papma, Janne Pievani, Michela Pijnenburg, Yolande Premi, Enrico Prioni, Sara Prix, Catharina Rademakers, Rosa Redaelli, Veronica Rogaeva, Ekaterina Rosa-Neto, Pedro Rossi, Giacomina Rosser, Martin |
author_role |
author |
author2 |
Borchert, Robin Jones, Simon van Swieten, John Borroni, Barbara Galimberti, Daniela Masellis, Mario Tartaglia, Maria Carmela Graff, Caroline Tagliavini, Fabrizio Frisoni, Giovanni B. Santiago, Beatriz Scarpini, Elio Schönecker, Sonja Semler, Elisa Shafei, Rachelle Shoesmith, Christen Tábuas-Pereira, Miguel Tainta, Mikel Taipa, Ricardo Tang-Wai, David Laforce, Robert Thomas, David L. Thonberg, Hakan Timberlake, Carolyn Tiraboschi, Pietro Vandamme, Philip Vandenbulcke, Mathieu Veldsman, Michele Verdelho, Ana Villanua, Jorge Warren, Jason Finger, Elizabeth Wilke, Carlo Woollacott, Ione Wlasich, Elisabeth Zetterberg, Henrik Zulaica, Miren De Mendonça, Alexandre Sorbi, Sandro Rohrer, Jonathan D. Rowe, James B. Afonso, Sónia Almeida, Maria Rosario Anderl-Straub, Sarah Andersson, Christin Antonell, Anna Archetti, Silvana Arighi, Andrea Balasa, Mircea Barandiaran, Myriam Bargalló, Nuria Bartha, Robart Bender, Benjamin Benussi, Luisa Bessi, Valentina Binetti, Giuliano Black, Sandra Bocchetta, Martina Borrego-Ecija, Sergi Bras, Jose Bruffaerts, Rose Caroppo, Paola Cash, David Castelo-Branco, Miguel Convery, Rhian Cope, Thomas Cosseddu, Maura de Arriba, María Di Fede, Giuseppe Díaz, Zigor Dick, Katrina M. Duro, Diana Fenoglio, Chiara Ferrari, Camilla Ferreira, Catarina B. Flanagana, Toby Fox, Nick Freedman, Morris Fumagalli, Giorgio Gabilondo, Alazne Gasparotti, Roberto Gauthier, Serge Gazzina, Stefano Ghidoni, Roberta Giaccone, Giorgio Gorostidi, Ana Greaves, Caroline Guerreiro, Rita Heller, Carolin Hoegen, Tobias Indakoetxea, Begoña Jelic, Vesna Jiskoot, Lize Karnath, Hans-Otto Keren, Ron Leitão, Maria João Lladó, Albert Lombardi, Gemma Loosli, Sandra Maruta, Carolina Mead, Simon Meeter, Lieke Miltenberger-Miltenyi, Gabriel van Minkelen, Rick Mitchell, Sara Nacmias, Benedetta Neason, Mollie Nicholas, Jennifer Öijerstedt, Linn Olives, Jaume Padovani, Alessandro Panman, Jessica Papma, Janne Pievani, Michela Pijnenburg, Yolande Premi, Enrico Prioni, Sara Prix, Catharina Rademakers, Rosa Redaelli, Veronica Rogaeva, Ekaterina Rosa-Neto, Pedro Rossi, Giacomina Rosser, Martin |
author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Repositório da Universidade de Lisboa |
dc.contributor.author.fl_str_mv |
Rittman, Timothy Borchert, Robin Jones, Simon van Swieten, John Borroni, Barbara Galimberti, Daniela Masellis, Mario Tartaglia, Maria Carmela Graff, Caroline Tagliavini, Fabrizio Frisoni, Giovanni B. Santiago, Beatriz Scarpini, Elio Schönecker, Sonja Semler, Elisa Shafei, Rachelle Shoesmith, Christen Tábuas-Pereira, Miguel Tainta, Mikel Taipa, Ricardo Tang-Wai, David Laforce, Robert Thomas, David L. Thonberg, Hakan Timberlake, Carolyn Tiraboschi, Pietro Vandamme, Philip Vandenbulcke, Mathieu Veldsman, Michele Verdelho, Ana Villanua, Jorge Warren, Jason Finger, Elizabeth Wilke, Carlo Woollacott, Ione Wlasich, Elisabeth Zetterberg, Henrik Zulaica, Miren De Mendonça, Alexandre Sorbi, Sandro Rohrer, Jonathan D. Rowe, James B. Afonso, Sónia Almeida, Maria Rosario Anderl-Straub, Sarah Andersson, Christin Antonell, Anna Archetti, Silvana Arighi, Andrea Balasa, Mircea Barandiaran, Myriam Bargalló, Nuria Bartha, Robart Bender, Benjamin Benussi, Luisa Bessi, Valentina Binetti, Giuliano Black, Sandra Bocchetta, Martina Borrego-Ecija, Sergi Bras, Jose Bruffaerts, Rose Caroppo, Paola Cash, David Castelo-Branco, Miguel Convery, Rhian Cope, Thomas Cosseddu, Maura de Arriba, María Di Fede, Giuseppe Díaz, Zigor Dick, Katrina M. Duro, Diana Fenoglio, Chiara Ferrari, Camilla Ferreira, Catarina B. Flanagana, Toby Fox, Nick Freedman, Morris Fumagalli, Giorgio Gabilondo, Alazne Gasparotti, Roberto Gauthier, Serge Gazzina, Stefano Ghidoni, Roberta Giaccone, Giorgio Gorostidi, Ana Greaves, Caroline Guerreiro, Rita Heller, Carolin Hoegen, Tobias Indakoetxea, Begoña Jelic, Vesna Jiskoot, Lize Karnath, Hans-Otto Keren, Ron Leitão, Maria João Lladó, Albert Lombardi, Gemma Loosli, Sandra Maruta, Carolina Mead, Simon Meeter, Lieke Miltenberger-Miltenyi, Gabriel van Minkelen, Rick Mitchell, Sara Nacmias, Benedetta Neason, Mollie Nicholas, Jennifer Öijerstedt, Linn Olives, Jaume Padovani, Alessandro Panman, Jessica Papma, Janne Pievani, Michela Pijnenburg, Yolande Premi, Enrico Prioni, Sara Prix, Catharina Rademakers, Rosa Redaelli, Veronica Rogaeva, Ekaterina Rosa-Neto, Pedro Rossi, Giacomina Rosser, Martin |
dc.subject.por.fl_str_mv |
Cognition Connectivity Frontotemporal dementia Functional imaging Genetics |
topic |
Cognition Connectivity Frontotemporal dementia Functional imaging Genetics |
description |
© 2019 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/) |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019 2019-01-01T00:00:00Z 2022-05-09T11:41:06Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10451/52792 |
url |
http://hdl.handle.net/10451/52792 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Neurobiol Aging. 2019 May;77:169-177 0197-4580 10.1016/j.neurobiolaging.2018.12.009 1558-1497 |
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info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
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