Mid- and long-term anxiety levels associated with presymptomatic testing of Huntington's disease, Machado-Joseph disease, and familial amyloid polyneuropathy

Detalhes bibliográficos
Autor(a) principal: Lêdo, Susana
Data de Publicação: 2016
Outros Autores: Leite, Ângela, Souto, Teresa, Dinis, Maria Alzira Pimenta, Sequeiros, Jorge
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10284/7853
Resumo: http://sherpa.ac.uk/romeo/search.php?issn=1809-452X
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spelling Mid- and long-term anxiety levels associated with presymptomatic testing of Huntington's disease, Machado-Joseph disease, and familial amyloid polyneuropathyAdultAgedAmyloid Neuropathies, FamilialAnxietyAsymptomatic DiseasesCross-Sectional StudiesFemaleHumansHuntington DiseaseMachado-Joseph DiseaseMaleMiddle AgedPortugalPredictive Value of TestsSurveys and QuestionnairesTime Factorshttp://sherpa.ac.uk/romeo/search.php?issn=1809-452XOBJECTIVE: To study anxiety as a variable of the mid- and long-term psychological impact of pre-symptomatic testing for three autosomal dominant late-onset disorders - Huntington's disease (HD), Machado-Joseph disease (MJD) and familial amyloid polyneuropathy (FAP) TTR V30M - in a Portuguese sample. METHODS: This cross-sectional study included 203 participants: 170 (83.7%) underwent pre-symptomatic testing for FAP, 29 (14.3%) for HD, and 4 (2%) for MJD. Of the 203 participants, 73 (36.0%) were asymptomatic carriers, 29 (14.5%) were symptomatic carriers, 9 (4.5%) were diagnosed with FAP and had a liver transplant, and 89 (44.5%) were non-carriers. Most were women (58.1%) and married (66.5%). The anxiety variable was assessed using the Zung Self-Rating Anxiety Scale (SAS). RESULTS: The anxiety scores were higher for symptomatic carriers and for those who underwent psychological support consultations over the years. For symptomatic carriers, the mean scores were superior to 40 points, which reflects clinical anxiety. CONCLUSION: Although it was not possible to differentiate between the mid- and long-term psychological impacts, this study supports the conclusion that the proximity to the age of symptoms onset might be a trigger for anxiety.Associação Brasileira de PsiquiatriaRepositório Institucional da Universidade Fernando PessoaLêdo, SusanaLeite, ÂngelaSouto, TeresaDinis, Maria Alzira PimentaSequeiros, Jorge2019-09-13T12:46:26Z2016-01-01T00:00:00Z2016-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10284/7853engAPA: Lêdo, S., Leite, Â., Souto, T., Dinis, M. A., & Sequeiros, J. (2016). Mid- and long-term anxiety levels associated with presymptomatic testing of Huntington's disease, Machado-Joseph disease, and familial amyloid polyneuropathy. Revista Brasileira de Psiquiatria, 38(2), 113-120. doi:10.1590/1516-4446-2014-16171809-452X10.1590/1516-4446-2014-1617info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-09-06T02:07:14Zoai:bdigital.ufp.pt:10284/7853Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T15:44:47.214233Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Mid- and long-term anxiety levels associated with presymptomatic testing of Huntington's disease, Machado-Joseph disease, and familial amyloid polyneuropathy
title Mid- and long-term anxiety levels associated with presymptomatic testing of Huntington's disease, Machado-Joseph disease, and familial amyloid polyneuropathy
spellingShingle Mid- and long-term anxiety levels associated with presymptomatic testing of Huntington's disease, Machado-Joseph disease, and familial amyloid polyneuropathy
Lêdo, Susana
Adult
Aged
Amyloid Neuropathies, Familial
Anxiety
Asymptomatic Diseases
Cross-Sectional Studies
Female
Humans
Huntington Disease
Machado-Joseph Disease
Male
Middle Aged
Portugal
Predictive Value of Tests
Surveys and Questionnaires
Time Factors
title_short Mid- and long-term anxiety levels associated with presymptomatic testing of Huntington's disease, Machado-Joseph disease, and familial amyloid polyneuropathy
title_full Mid- and long-term anxiety levels associated with presymptomatic testing of Huntington's disease, Machado-Joseph disease, and familial amyloid polyneuropathy
title_fullStr Mid- and long-term anxiety levels associated with presymptomatic testing of Huntington's disease, Machado-Joseph disease, and familial amyloid polyneuropathy
title_full_unstemmed Mid- and long-term anxiety levels associated with presymptomatic testing of Huntington's disease, Machado-Joseph disease, and familial amyloid polyneuropathy
title_sort Mid- and long-term anxiety levels associated with presymptomatic testing of Huntington's disease, Machado-Joseph disease, and familial amyloid polyneuropathy
author Lêdo, Susana
author_facet Lêdo, Susana
Leite, Ângela
Souto, Teresa
Dinis, Maria Alzira Pimenta
Sequeiros, Jorge
author_role author
author2 Leite, Ângela
Souto, Teresa
Dinis, Maria Alzira Pimenta
Sequeiros, Jorge
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Repositório Institucional da Universidade Fernando Pessoa
dc.contributor.author.fl_str_mv Lêdo, Susana
Leite, Ângela
Souto, Teresa
Dinis, Maria Alzira Pimenta
Sequeiros, Jorge
dc.subject.por.fl_str_mv Adult
Aged
Amyloid Neuropathies, Familial
Anxiety
Asymptomatic Diseases
Cross-Sectional Studies
Female
Humans
Huntington Disease
Machado-Joseph Disease
Male
Middle Aged
Portugal
Predictive Value of Tests
Surveys and Questionnaires
Time Factors
topic Adult
Aged
Amyloid Neuropathies, Familial
Anxiety
Asymptomatic Diseases
Cross-Sectional Studies
Female
Humans
Huntington Disease
Machado-Joseph Disease
Male
Middle Aged
Portugal
Predictive Value of Tests
Surveys and Questionnaires
Time Factors
description http://sherpa.ac.uk/romeo/search.php?issn=1809-452X
publishDate 2016
dc.date.none.fl_str_mv 2016-01-01T00:00:00Z
2016-01-01T00:00:00Z
2019-09-13T12:46:26Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10284/7853
url http://hdl.handle.net/10284/7853
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv APA: Lêdo, S., Leite, Â., Souto, T., Dinis, M. A., & Sequeiros, J. (2016). Mid- and long-term anxiety levels associated with presymptomatic testing of Huntington's disease, Machado-Joseph disease, and familial amyloid polyneuropathy. Revista Brasileira de Psiquiatria, 38(2), 113-120. doi:10.1590/1516-4446-2014-1617
1809-452X
10.1590/1516-4446-2014-1617
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Associação Brasileira de Psiquiatria
publisher.none.fl_str_mv Associação Brasileira de Psiquiatria
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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