TET enzymes and DNA hydroxymethylation in neural development and function : how critical are they?

Detalhes bibliográficos
Autor(a) principal: Pereira, Mafalda Santiago
Data de Publicação: 2014
Outros Autores: Antunes, Cláudia, Guedes, Marta, Sousa, Nuno, Marques, C. Joana
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/32961
Resumo: Epigenetic modifications of the genome play important roles in controlling gene transcription thus regulating several molecular and cellular processes. A novel epigenetic modification - 5-hydroxymethylcytosine (5hmC) - has been recently described and attracted a lot of attention due to its possible involvement in the active DNA demethylation mechanism. TET enzymes are dioxygenases capable of oxidizing the methyl group of 5-methylcytosines (5mC) and thus converting 5mC into 5hmC. Although most of the work on TET enzymes and 5hmC has been carried out in embryonic stem (ES) cells, the highest levels of 5hmC occur in the brain and in neurons, pointing to a role for this epigenetic modification in the control of neuronal differentiation, neural plasticity and brain functions. Here we review the most recent advances on the role of TET enzymes and DNA hydroxymethylation in neuronal differentiation and function.
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spelling TET enzymes and DNA hydroxymethylation in neural development and function : how critical are they?5-HydroxymethylcytosineTET enzymesEpigenetic regulationNeural development6 BrainBrainScience & TechnologyEpigenetic modifications of the genome play important roles in controlling gene transcription thus regulating several molecular and cellular processes. A novel epigenetic modification - 5-hydroxymethylcytosine (5hmC) - has been recently described and attracted a lot of attention due to its possible involvement in the active DNA demethylation mechanism. TET enzymes are dioxygenases capable of oxidizing the methyl group of 5-methylcytosines (5mC) and thus converting 5mC into 5hmC. Although most of the work on TET enzymes and 5hmC has been carried out in embryonic stem (ES) cells, the highest levels of 5hmC occur in the brain and in neurons, pointing to a role for this epigenetic modification in the control of neuronal differentiation, neural plasticity and brain functions. Here we review the most recent advances on the role of TET enzymes and DNA hydroxymethylation in neuronal differentiation and function.We apologize to those researchers whose important work we were not able to cite. We would like to thank all members of the Neurosciences Research Domain (ICVS) for useful discussions, in particular Luisa Pinto and Joao Oliveira for critically reading the manuscript. Our work is funded by the Fundacao para a Ciencia e Tecnologia (FCT, Portugal) and Compete Program with the project reference PTDC/BIA-BCM/121276/2010. C.J. Marques is the recipient of an FCT Investigator Starting Grant.Academic PressUniversidade do MinhoPereira, Mafalda SantiagoAntunes, CláudiaGuedes, MartaSousa, NunoMarques, C. Joana20142014-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/32961eng0888-754310.1016/j.ygeno.2014.08.01825200796www.elsevier.cominfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:35:17Zoai:repositorium.sdum.uminho.pt:1822/32961Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:31:07.347255Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv TET enzymes and DNA hydroxymethylation in neural development and function : how critical are they?
title TET enzymes and DNA hydroxymethylation in neural development and function : how critical are they?
spellingShingle TET enzymes and DNA hydroxymethylation in neural development and function : how critical are they?
Pereira, Mafalda Santiago
5-Hydroxymethylcytosine
TET enzymes
Epigenetic regulation
Neural development
6 Brain
Brain
Science & Technology
title_short TET enzymes and DNA hydroxymethylation in neural development and function : how critical are they?
title_full TET enzymes and DNA hydroxymethylation in neural development and function : how critical are they?
title_fullStr TET enzymes and DNA hydroxymethylation in neural development and function : how critical are they?
title_full_unstemmed TET enzymes and DNA hydroxymethylation in neural development and function : how critical are they?
title_sort TET enzymes and DNA hydroxymethylation in neural development and function : how critical are they?
author Pereira, Mafalda Santiago
author_facet Pereira, Mafalda Santiago
Antunes, Cláudia
Guedes, Marta
Sousa, Nuno
Marques, C. Joana
author_role author
author2 Antunes, Cláudia
Guedes, Marta
Sousa, Nuno
Marques, C. Joana
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Pereira, Mafalda Santiago
Antunes, Cláudia
Guedes, Marta
Sousa, Nuno
Marques, C. Joana
dc.subject.por.fl_str_mv 5-Hydroxymethylcytosine
TET enzymes
Epigenetic regulation
Neural development
6 Brain
Brain
Science & Technology
topic 5-Hydroxymethylcytosine
TET enzymes
Epigenetic regulation
Neural development
6 Brain
Brain
Science & Technology
description Epigenetic modifications of the genome play important roles in controlling gene transcription thus regulating several molecular and cellular processes. A novel epigenetic modification - 5-hydroxymethylcytosine (5hmC) - has been recently described and attracted a lot of attention due to its possible involvement in the active DNA demethylation mechanism. TET enzymes are dioxygenases capable of oxidizing the methyl group of 5-methylcytosines (5mC) and thus converting 5mC into 5hmC. Although most of the work on TET enzymes and 5hmC has been carried out in embryonic stem (ES) cells, the highest levels of 5hmC occur in the brain and in neurons, pointing to a role for this epigenetic modification in the control of neuronal differentiation, neural plasticity and brain functions. Here we review the most recent advances on the role of TET enzymes and DNA hydroxymethylation in neuronal differentiation and function.
publishDate 2014
dc.date.none.fl_str_mv 2014
2014-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/32961
url http://hdl.handle.net/1822/32961
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0888-7543
10.1016/j.ygeno.2014.08.018
25200796
www.elsevier.com
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Academic Press
publisher.none.fl_str_mv Academic Press
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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