Bullous pemphigoid and multiple myeloma: a case report

Detalhes bibliográficos
Autor(a) principal: Mendes, Joana Catarina Santos
Data de Publicação: 2022
Outros Autores: Costa, Rui Miguel Tavares
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://doi.org/10.32385/rpmgf.v38i6.13199
Resumo: Introduction: Autoimmune bullous skin diseases are rare pathologies. Among these, bullous pemphigoid is the most common subepidermal autoimmune bullous disease. The concomitant occurrence of bullous pemphigoid and malignancy has been reported in the literature, however, the evidence of this association remains controversial. This case report aims to raise awareness of this pathology’s existence, and its possible association with malignancy, and highlight the importance of several characteristics of general practice/family medicine. Case description: A 73-year-old woman with a history of diabetes mellitus, high blood pressure, and recurrent depressive disorder. No alcoholic, smoking, or toxiphilic habits. She constitutes a unitary family. Throughout several medical appointments, she presented with skin lesions (initially nonspecific lesions and later on tense bullous lesions), associated with pruritus, constitutional symptoms, and anemia, which started almost at the same time. Diagnoses of bullous pemphigoid and multiple myeloma were made. She was treated with oral corticosteroid therapy and has achieved complete resolution of the cutaneous symptoms. She later started chemotherapy and that improved her constitutional symptoms. She remains autonomous, living alone, with good family support. Comment: Bullous pemphigoid is a skin condition that family physicians should be aware of. Its possible association with malignancy is not proven. However, in patients with a recent diagnosis of bullous pemphigoid, although the search for neoplasms cannot be recommended beyond the usual oncological screenings, we suggest that a comprehensive assessment should be carried out, especially if there are suspicious signs and symptoms. The exposed clinical case also highlights the importance of all the characteristics of general practice/family medicine.
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spelling Bullous pemphigoid and multiple myeloma: a case reportPenfigoide bolhoso e mieloma múltiplo: um relato de casoDermatoses bolhosasPenfigoide bolhosoNeoplasias malignasMieloma múltiploRelato de casoBullous skin diseasesBullous pemphigoidMalignancyMultiple myelomaCare reportIntroduction: Autoimmune bullous skin diseases are rare pathologies. Among these, bullous pemphigoid is the most common subepidermal autoimmune bullous disease. The concomitant occurrence of bullous pemphigoid and malignancy has been reported in the literature, however, the evidence of this association remains controversial. This case report aims to raise awareness of this pathology’s existence, and its possible association with malignancy, and highlight the importance of several characteristics of general practice/family medicine. Case description: A 73-year-old woman with a history of diabetes mellitus, high blood pressure, and recurrent depressive disorder. No alcoholic, smoking, or toxiphilic habits. She constitutes a unitary family. Throughout several medical appointments, she presented with skin lesions (initially nonspecific lesions and later on tense bullous lesions), associated with pruritus, constitutional symptoms, and anemia, which started almost at the same time. Diagnoses of bullous pemphigoid and multiple myeloma were made. She was treated with oral corticosteroid therapy and has achieved complete resolution of the cutaneous symptoms. She later started chemotherapy and that improved her constitutional symptoms. She remains autonomous, living alone, with good family support. Comment: Bullous pemphigoid is a skin condition that family physicians should be aware of. Its possible association with malignancy is not proven. However, in patients with a recent diagnosis of bullous pemphigoid, although the search for neoplasms cannot be recommended beyond the usual oncological screenings, we suggest that a comprehensive assessment should be carried out, especially if there are suspicious signs and symptoms. The exposed clinical case also highlights the importance of all the characteristics of general practice/family medicine.Introdução: As doenças cutâneas bolhosas autoimunes são patologias raras, sendo o penfigoide bolhoso a doença bolhosa autoimune subepidérmica mais comum. A ocorrência concomitante de penfigoide bolhoso e neoplasias malignas tem sido relatada na literatura; contudo, a evidência dessa associação permanece controversa. Este relato de caso tem como objetivo sensibilizar para a existência desta patologia, a sua possível associação com as neoplasias malignas, nomeadamente com o mieloma múltiplo, e realçar a importância de várias características da medicina geral e familiar. Descrição do caso: Descreve-se o caso de uma mulher de 73 anos, com antecedentes de diabetes mellitus, hipertensão arterial e perturbação depressiva recorrente. Sem hábitos alcoólicos, tabágicos ou toxifílicos. Constitui uma família de tipo unitário.  Apresentou-se, ao longo de várias consultas, com quadro de lesões cutâneas (inicialmente lesões inespecíficas e posteriormente lesões bolhosas tensas), associadas a prurido, sintomas constitucionais e anemia, iniciados quase concomitantemente. Foram efetuados os diagnósticos de penfigoide bolhoso e mieloma múltiplo. A doente foi submetida a tratamento com corticoterapia oral, tendo obtido resolução completa da sintomatologia cutânea. Iniciou, posteriormente, quimioterapia, com melhoria dos sintomas constitucionais. Permanece autónoma, a habitar sozinha, com bom suporte familiar por parte dos filhos. Comentário: O penfigoide bolhoso é uma patologia cutânea para a qual os médicos de família devem estar alerta. A sua possível associação com as neoplasias malignas não se encontra comprovada. Ainda assim, em doentes com diagnóstico recente de penfigoide bolhoso, embora não se possa recomendar a pesquisa de neoplasias para além dos rastreios oncológicos habitualmente preconizados, sugere-se que seja efetuada uma avaliação abrangente, sobretudo se existirem sinais e sintomas suspeitos.  O caso clínico exposto realça ainda a importância de praticamente todas as características da medicina geral e familiar na prestação de cuidados de saúde.Associação Portuguesa de Medicina Geral e Familiar2022-12-30info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://doi.org/10.32385/rpmgf.v38i6.13199https://doi.org/10.32385/rpmgf.v38i6.13199Portuguese Journal of Family Medicine and General Practice; Vol. 38 No. 6 (2022): Revista Portuguesa de Medicina Geral e Familiar; 606-10Revista Portuguesa de Medicina Geral e Familiar; Vol. 38 Núm. 6 (2022): Revista Portuguesa de Medicina Geral e Familiar; 606-10Revista Portuguesa de Medicina Geral e Familiar; Vol. 38 N.º 6 (2022): Revista Portuguesa de Medicina Geral e Familiar; 606-102182-51812182-517310.32385/rpmgf.v38i6reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPporhttps://rpmgf.pt/ojs/index.php/rpmgf/article/view/13199https://rpmgf.pt/ojs/index.php/rpmgf/article/view/13199/11823Direitos de Autor (c) 2022 Revista Portuguesa de Medicina Geral e Familiarhttp://creativecommons.org/licenses/by-nc-nd/4.0info:eu-repo/semantics/openAccessMendes, Joana Catarina SantosCosta, Rui Miguel Tavares2024-09-17T12:00:28Zoai:ojs.rpmgf.pt:article/13199Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-09-17T12:00:28Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Bullous pemphigoid and multiple myeloma: a case report
Penfigoide bolhoso e mieloma múltiplo: um relato de caso
title Bullous pemphigoid and multiple myeloma: a case report
spellingShingle Bullous pemphigoid and multiple myeloma: a case report
Mendes, Joana Catarina Santos
Dermatoses bolhosas
Penfigoide bolhoso
Neoplasias malignas
Mieloma múltiplo
Relato de caso
Bullous skin diseases
Bullous pemphigoid
Malignancy
Multiple myeloma
Care report
title_short Bullous pemphigoid and multiple myeloma: a case report
title_full Bullous pemphigoid and multiple myeloma: a case report
title_fullStr Bullous pemphigoid and multiple myeloma: a case report
title_full_unstemmed Bullous pemphigoid and multiple myeloma: a case report
title_sort Bullous pemphigoid and multiple myeloma: a case report
author Mendes, Joana Catarina Santos
author_facet Mendes, Joana Catarina Santos
Costa, Rui Miguel Tavares
author_role author
author2 Costa, Rui Miguel Tavares
author2_role author
dc.contributor.author.fl_str_mv Mendes, Joana Catarina Santos
Costa, Rui Miguel Tavares
dc.subject.por.fl_str_mv Dermatoses bolhosas
Penfigoide bolhoso
Neoplasias malignas
Mieloma múltiplo
Relato de caso
Bullous skin diseases
Bullous pemphigoid
Malignancy
Multiple myeloma
Care report
topic Dermatoses bolhosas
Penfigoide bolhoso
Neoplasias malignas
Mieloma múltiplo
Relato de caso
Bullous skin diseases
Bullous pemphigoid
Malignancy
Multiple myeloma
Care report
description Introduction: Autoimmune bullous skin diseases are rare pathologies. Among these, bullous pemphigoid is the most common subepidermal autoimmune bullous disease. The concomitant occurrence of bullous pemphigoid and malignancy has been reported in the literature, however, the evidence of this association remains controversial. This case report aims to raise awareness of this pathology’s existence, and its possible association with malignancy, and highlight the importance of several characteristics of general practice/family medicine. Case description: A 73-year-old woman with a history of diabetes mellitus, high blood pressure, and recurrent depressive disorder. No alcoholic, smoking, or toxiphilic habits. She constitutes a unitary family. Throughout several medical appointments, she presented with skin lesions (initially nonspecific lesions and later on tense bullous lesions), associated with pruritus, constitutional symptoms, and anemia, which started almost at the same time. Diagnoses of bullous pemphigoid and multiple myeloma were made. She was treated with oral corticosteroid therapy and has achieved complete resolution of the cutaneous symptoms. She later started chemotherapy and that improved her constitutional symptoms. She remains autonomous, living alone, with good family support. Comment: Bullous pemphigoid is a skin condition that family physicians should be aware of. Its possible association with malignancy is not proven. However, in patients with a recent diagnosis of bullous pemphigoid, although the search for neoplasms cannot be recommended beyond the usual oncological screenings, we suggest that a comprehensive assessment should be carried out, especially if there are suspicious signs and symptoms. The exposed clinical case also highlights the importance of all the characteristics of general practice/family medicine.
publishDate 2022
dc.date.none.fl_str_mv 2022-12-30
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.uri.fl_str_mv https://doi.org/10.32385/rpmgf.v38i6.13199
https://doi.org/10.32385/rpmgf.v38i6.13199
url https://doi.org/10.32385/rpmgf.v38i6.13199
dc.language.iso.fl_str_mv por
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dc.relation.none.fl_str_mv https://rpmgf.pt/ojs/index.php/rpmgf/article/view/13199
https://rpmgf.pt/ojs/index.php/rpmgf/article/view/13199/11823
dc.rights.driver.fl_str_mv Direitos de Autor (c) 2022 Revista Portuguesa de Medicina Geral e Familiar
http://creativecommons.org/licenses/by-nc-nd/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Direitos de Autor (c) 2022 Revista Portuguesa de Medicina Geral e Familiar
http://creativecommons.org/licenses/by-nc-nd/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Associação Portuguesa de Medicina Geral e Familiar
publisher.none.fl_str_mv Associação Portuguesa de Medicina Geral e Familiar
dc.source.none.fl_str_mv Portuguese Journal of Family Medicine and General Practice; Vol. 38 No. 6 (2022): Revista Portuguesa de Medicina Geral e Familiar; 606-10
Revista Portuguesa de Medicina Geral e Familiar; Vol. 38 Núm. 6 (2022): Revista Portuguesa de Medicina Geral e Familiar; 606-10
Revista Portuguesa de Medicina Geral e Familiar; Vol. 38 N.º 6 (2022): Revista Portuguesa de Medicina Geral e Familiar; 606-10
2182-5181
2182-5173
10.32385/rpmgf.v38i6
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