Berger's disease in childhood. The clinical, laboratory and histological aspects. A collaborative multicenter study of the Pediatric Nephrology Section of the Portuguese Society of Pediatrics.
Autor(a) principal: | |
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Data de Publicação: | 1993 |
Outros Autores: | |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/3147 |
Resumo: | After a multicentric questionnaire, a clinicopathological study was performed retrospectively in 35 children with Berger's Disease. The sex ratio was 2.8/1 (M/F) and the mean age of onset was 8.5 years. Gross hematuria was the presenting sign in all the patients, being isolated in 20 and associated with proteinuria in the others. 2.3 was mean number of episodes per year and they lasted from 1 to 4 days in 14 patients and from 5 to 15 in the remaining. In 32 patients the episodes were related to a previous respiratory infection and in the meantime 34 patients had persistent microscopic hematuria. Seric IgA was raised in 67% of the patients during the episodes and in 45% between them. The histopathological studies demonstrated, by immunofluorescence microscopy, besides mesangial deposits of IgA in all the patients, C3 deposits in 17, IgG in 9 and IgM in 5 and by optic microscopy 31 cases had mesangial hypercellularity (2 with crescents in less than 50% of the glomeruli) and 4 minimal lesions. None of the 35 patients developed renal failure (4.6 years mean follow-up). |
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Berger's disease in childhood. The clinical, laboratory and histological aspects. A collaborative multicenter study of the Pediatric Nephrology Section of the Portuguese Society of Pediatrics.Doença de Berger na criança. Aspectos clínicos, laboratoriais e histológicos. Estudo colaborativo multicêntrico da Secção de Nefrologia Pediátrica da Sociedade Portuguesa de Pediatria.After a multicentric questionnaire, a clinicopathological study was performed retrospectively in 35 children with Berger's Disease. The sex ratio was 2.8/1 (M/F) and the mean age of onset was 8.5 years. Gross hematuria was the presenting sign in all the patients, being isolated in 20 and associated with proteinuria in the others. 2.3 was mean number of episodes per year and they lasted from 1 to 4 days in 14 patients and from 5 to 15 in the remaining. In 32 patients the episodes were related to a previous respiratory infection and in the meantime 34 patients had persistent microscopic hematuria. Seric IgA was raised in 67% of the patients during the episodes and in 45% between them. The histopathological studies demonstrated, by immunofluorescence microscopy, besides mesangial deposits of IgA in all the patients, C3 deposits in 17, IgG in 9 and IgM in 5 and by optic microscopy 31 cases had mesangial hypercellularity (2 with crescents in less than 50% of the glomeruli) and 4 minimal lesions. None of the 35 patients developed renal failure (4.6 years mean follow-up).After a multicentric questionnaire, a clinicopathological study was performed retrospectively in 35 children with Berger's Disease. The sex ratio was 2.8/1 (M/F) and the mean age of onset was 8.5 years. Gross hematuria was the presenting sign in all the patients, being isolated in 20 and associated with proteinuria in the others. 2.3 was mean number of episodes per year and they lasted from 1 to 4 days in 14 patients and from 5 to 15 in the remaining. In 32 patients the episodes were related to a previous respiratory infection and in the meantime 34 patients had persistent microscopic hematuria. Seric IgA was raised in 67% of the patients during the episodes and in 45% between them. The histopathological studies demonstrated, by immunofluorescence microscopy, besides mesangial deposits of IgA in all the patients, C3 deposits in 17, IgG in 9 and IgM in 5 and by optic microscopy 31 cases had mesangial hypercellularity (2 with crescents in less than 50% of the glomeruli) and 4 minimal lesions. None of the 35 patients developed renal failure (4.6 years mean follow-up).Ordem dos Médicos1993-10-30info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/3147oai:ojs.www.actamedicaportuguesa.com:article/3147Acta Médica Portuguesa; Vol. 6 No. 10 (1993): Outubro; 439-41Acta Médica Portuguesa; Vol. 6 N.º 10 (1993): Outubro; 439-411646-07580870-399Xreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPporhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/3147https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/3147/2486Stone, RSá, Ginfo:eu-repo/semantics/openAccess2022-12-20T11:01:41ZPortal AgregadorONG |
dc.title.none.fl_str_mv |
Berger's disease in childhood. The clinical, laboratory and histological aspects. A collaborative multicenter study of the Pediatric Nephrology Section of the Portuguese Society of Pediatrics. Doença de Berger na criança. Aspectos clínicos, laboratoriais e histológicos. Estudo colaborativo multicêntrico da Secção de Nefrologia Pediátrica da Sociedade Portuguesa de Pediatria. |
title |
Berger's disease in childhood. The clinical, laboratory and histological aspects. A collaborative multicenter study of the Pediatric Nephrology Section of the Portuguese Society of Pediatrics. |
spellingShingle |
Berger's disease in childhood. The clinical, laboratory and histological aspects. A collaborative multicenter study of the Pediatric Nephrology Section of the Portuguese Society of Pediatrics. Stone, R |
title_short |
Berger's disease in childhood. The clinical, laboratory and histological aspects. A collaborative multicenter study of the Pediatric Nephrology Section of the Portuguese Society of Pediatrics. |
title_full |
Berger's disease in childhood. The clinical, laboratory and histological aspects. A collaborative multicenter study of the Pediatric Nephrology Section of the Portuguese Society of Pediatrics. |
title_fullStr |
Berger's disease in childhood. The clinical, laboratory and histological aspects. A collaborative multicenter study of the Pediatric Nephrology Section of the Portuguese Society of Pediatrics. |
title_full_unstemmed |
Berger's disease in childhood. The clinical, laboratory and histological aspects. A collaborative multicenter study of the Pediatric Nephrology Section of the Portuguese Society of Pediatrics. |
title_sort |
Berger's disease in childhood. The clinical, laboratory and histological aspects. A collaborative multicenter study of the Pediatric Nephrology Section of the Portuguese Society of Pediatrics. |
author |
Stone, R |
author_facet |
Stone, R Sá, G |
author_role |
author |
author2 |
Sá, G |
author2_role |
author |
dc.contributor.author.fl_str_mv |
Stone, R Sá, G |
description |
After a multicentric questionnaire, a clinicopathological study was performed retrospectively in 35 children with Berger's Disease. The sex ratio was 2.8/1 (M/F) and the mean age of onset was 8.5 years. Gross hematuria was the presenting sign in all the patients, being isolated in 20 and associated with proteinuria in the others. 2.3 was mean number of episodes per year and they lasted from 1 to 4 days in 14 patients and from 5 to 15 in the remaining. In 32 patients the episodes were related to a previous respiratory infection and in the meantime 34 patients had persistent microscopic hematuria. Seric IgA was raised in 67% of the patients during the episodes and in 45% between them. The histopathological studies demonstrated, by immunofluorescence microscopy, besides mesangial deposits of IgA in all the patients, C3 deposits in 17, IgG in 9 and IgM in 5 and by optic microscopy 31 cases had mesangial hypercellularity (2 with crescents in less than 50% of the glomeruli) and 4 minimal lesions. None of the 35 patients developed renal failure (4.6 years mean follow-up). |
publishDate |
1993 |
dc.date.none.fl_str_mv |
1993-10-30 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/3147 oai:ojs.www.actamedicaportuguesa.com:article/3147 |
url |
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/3147 |
identifier_str_mv |
oai:ojs.www.actamedicaportuguesa.com:article/3147 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/3147 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/3147/2486 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Ordem dos Médicos |
publisher.none.fl_str_mv |
Ordem dos Médicos |
dc.source.none.fl_str_mv |
Acta Médica Portuguesa; Vol. 6 No. 10 (1993): Outubro; 439-41 Acta Médica Portuguesa; Vol. 6 N.º 10 (1993): Outubro; 439-41 1646-0758 0870-399X reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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1777301639442464768 |