Hepatitis B and C in Europe: an update from the Global Burden of Disease Study 2019
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2023 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10451/61920 |
Resumo: | © 2023 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license. |
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Hepatitis B and C in Europe: an update from the Global Burden of Disease Study 2019© 2023 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license.Background In 2016, the World Health Assembly adopted the resolution to eliminate viral hepatitis by 2030. This study aims to provide an overview of the burdens of hepatitis B virus (HBV) and hepatitis C virus (HCV) in Europe and their changes from 2010 to 2019 using estimates from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019. Methods We used GBD 2019 estimates of the burden associated with HBV-related and HCV-related diseases: acute hepatitis, cirrhosis and other chronic liver diseases, and liver cancer. We report total numbers and age-standardised rates per 100 000 for mortality, prevalence, incidence, and disability-adjusted life-years (DALYs) from 2010 to 2019. For each HBV-related and HCV-related disease and each measure, we analysed temporal changes and percentage changes for the 2010–19 period. Findings In 2019, across all age groups, there were an estimated 2·08 million (95% uncertainty interval [UI] 1·66 to 2·54) incident cases of acute hepatitis B and 0·49 million (0·42 to 0·57) of hepatitis C in Europe. There were an estimated 8·24 million (7·56 to 8·88) prevalent cases of HBV-related cirrhosis and 11·87 million (9·77 to 14·41) of HCV-related cirrhosis, with 24·92 thousand (19·86 to 31·03) deaths due to HBV-related cirrhosis and 36·89 thousand (29·94 to 45·56) deaths due to HCV-related cirrhosis. Deaths were estimated at 9·00 thousand (6·88 to 11·62) due to HBV-related liver cancer and 23·07 thousand (18·95 to 27·31) due to HCV-related liver cancer. Between 2010 and 2019, the age-standardised incidence rate of acute hepatitis B decreased (–22·14% [95% UI –35·44 to –5·98]) as did its age-standardised mortality rate (–33·27% [–43·03 to –25·49]); the age-standardised prevalence rate (–20·60% [–22·09 to –19·10]) and mortality rate (–33·19% [–37·82 to –28·13]) of HBV-related cirrhosis also decreased in this time period. The age-standardised incidence rate of acute hepatitis C decreased by 3·24% (1·17 to 5·02) and its age-standardised mortality rate decreased by 35·73% (23·48 to 47·75) between 2010 and 2019; the age-standardised prevalence rate (–6·37% [–8·11 to –4·32]), incidence rate (–5·87% [–11·24 to –1·01]), and mortality rate (–11·11% [–16·54 to –5·53]) of HCV-related cirrhosis also decreased. No significant changes were observed in age-standardised rates of HBV-related and HCV-related liver cancer, although we observed a significant increase in numbers of cases of HCV-related liver cancer across all ages between 2010 and 2019 (16·41% [2·81 to 30·91] increase in prevalent cases). Substantial reductions in DALYs since 2010 were estimated for acute hepatitis B (–27·82% [–36·92 to –20·24]), acute hepatitis C (–27·07% [–15·97 to –39·34]), and HBV-related cirrhosis (–30·70% [–35·75 to –25·03]). A moderate reduction in DALYs was estimated for HCV-related cirrhosis (–6·19% [–0·19 to –12·57]). Only HCV-related liver cancer showed a significant increase in DALYs (10·37% [4·81–16·63]). Changes in age-standardised DALY rates closely resembled those observed for overall DALY counts, except for HCV-liver related cancer (–2·84% [–7·75 to 2·63]). Interpretation Although decreases in some HBV-related and HCV-related diseases were estimated between 2010 and 2019, HBV-related and HCV-related diseases are still associated with a high burden, highlighting the need for more intensive and coordinated interventions within European countries to reach the goal of elimination by 2030.Funding by Bill & Melinda Gates Foundation.ElsevierRepositório da Universidade de LisboaCortesi, Paolo AngeloFornari, CarlaConti, SaraAntonazzo, Ippazio CosimoFERRARA, PietroAhmed, AymanPalladino, ClaudiaTaveira, NunoGBD 2019 Europe Hepatitis B & C Collaborators2024-01-18T16:34:45Z2023-09-082023-09-15T14:49:51Z2023-09-08T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/61920engCortesi PA, Fornari C, Conti S, Antonazzo IC, Ferrara P, Ahmed A, et al. Hepatitis b and c in europe: an update from the global burden of disease study 2019. The Lancet Public Health [Internet]. setembro de 2023;8(9):e701–16. Disponível em: https://linkinghub.elsevier.com/retrieve/pii/S2468266723001494cv-prod-334171710.1016/S2468-2667(23)00149-437633679info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-01-22T01:20:24Zoai:repositorio.ul.pt:10451/61920Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T01:56:16.443525Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Hepatitis B and C in Europe: an update from the Global Burden of Disease Study 2019 |
| title |
Hepatitis B and C in Europe: an update from the Global Burden of Disease Study 2019 |
| spellingShingle |
Hepatitis B and C in Europe: an update from the Global Burden of Disease Study 2019 Cortesi, Paolo Angelo |
| title_short |
Hepatitis B and C in Europe: an update from the Global Burden of Disease Study 2019 |
| title_full |
Hepatitis B and C in Europe: an update from the Global Burden of Disease Study 2019 |
| title_fullStr |
Hepatitis B and C in Europe: an update from the Global Burden of Disease Study 2019 |
| title_full_unstemmed |
Hepatitis B and C in Europe: an update from the Global Burden of Disease Study 2019 |
| title_sort |
Hepatitis B and C in Europe: an update from the Global Burden of Disease Study 2019 |
| author |
Cortesi, Paolo Angelo |
| author_facet |
Cortesi, Paolo Angelo Fornari, Carla Conti, Sara Antonazzo, Ippazio Cosimo FERRARA, Pietro Ahmed, Ayman Palladino, Claudia Taveira, Nuno GBD 2019 Europe Hepatitis B & C Collaborators |
| author_role |
author |
| author2 |
Fornari, Carla Conti, Sara Antonazzo, Ippazio Cosimo FERRARA, Pietro Ahmed, Ayman Palladino, Claudia Taveira, Nuno GBD 2019 Europe Hepatitis B & C Collaborators |
| author2_role |
author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Repositório da Universidade de Lisboa |
| dc.contributor.author.fl_str_mv |
Cortesi, Paolo Angelo Fornari, Carla Conti, Sara Antonazzo, Ippazio Cosimo FERRARA, Pietro Ahmed, Ayman Palladino, Claudia Taveira, Nuno GBD 2019 Europe Hepatitis B & C Collaborators |
| description |
© 2023 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license. |
| publishDate |
2023 |
| dc.date.none.fl_str_mv |
2023-09-08 2023-09-15T14:49:51Z 2023-09-08T00:00:00Z 2024-01-18T16:34:45Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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http://hdl.handle.net/10451/61920 |
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http://hdl.handle.net/10451/61920 |
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eng |
| language |
eng |
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Cortesi PA, Fornari C, Conti S, Antonazzo IC, Ferrara P, Ahmed A, et al. Hepatitis b and c in europe: an update from the global burden of disease study 2019. The Lancet Public Health [Internet]. setembro de 2023;8(9):e701–16. Disponível em: https://linkinghub.elsevier.com/retrieve/pii/S2468266723001494 cv-prod-3341717 10.1016/S2468-2667(23)00149-4 37633679 |
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openAccess |
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application/pdf |
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Elsevier |
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Elsevier |
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