Dissolution and bulk erosion in viscoelastic materials: numerical study
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10316/44947 |
Resumo: | A mathematical model to simulate drug delivery from a vicoelastic erodible matrix is presented in this paper. The drug is initially distributed in the matrix which is in contact with water. The entrance of water in the material changes the molecular weight and bulk erosion can be developed depending on how fast is this entrance and how fast degradation occurs. The viscoelastic properties of the matrix also change in the presence of water as the molecular weight changes. The model is represented by a system of quasi linear partial differential equations that take into account different phenomena: the uptake of water, the decreasing of the molecular weight, the viscolestic behaviour, the dissolution of the solid drug and the delivery of the dissolved drug. Numerical simulations illustrating the behaviour of the model are included. |
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7160 |
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Dissolution and bulk erosion in viscoelastic materials: numerical studyA mathematical model to simulate drug delivery from a vicoelastic erodible matrix is presented in this paper. The drug is initially distributed in the matrix which is in contact with water. The entrance of water in the material changes the molecular weight and bulk erosion can be developed depending on how fast is this entrance and how fast degradation occurs. The viscoelastic properties of the matrix also change in the presence of water as the molecular weight changes. The model is represented by a system of quasi linear partial differential equations that take into account different phenomena: the uptake of water, the decreasing of the molecular weight, the viscolestic behaviour, the dissolution of the solid drug and the delivery of the dissolved drug. Numerical simulations illustrating the behaviour of the model are included.J. Vigo - Aguiar2014info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/44947http://hdl.handle.net/10316/44947eng978-84-616-9216-3http://cmmse.usal.es/cmmse2018/sites/default/files/volumes/Proceedings%20CMMSE-2014-volume1.pdfAzhdari, EbrahimFerreira, José AugustoOliveira, Paula deSilva, Pascoalinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2020-05-25T12:13:50Zoai:estudogeral.uc.pt:10316/44947Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:53:32.598029Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Dissolution and bulk erosion in viscoelastic materials: numerical study |
title |
Dissolution and bulk erosion in viscoelastic materials: numerical study |
spellingShingle |
Dissolution and bulk erosion in viscoelastic materials: numerical study Azhdari, Ebrahim |
title_short |
Dissolution and bulk erosion in viscoelastic materials: numerical study |
title_full |
Dissolution and bulk erosion in viscoelastic materials: numerical study |
title_fullStr |
Dissolution and bulk erosion in viscoelastic materials: numerical study |
title_full_unstemmed |
Dissolution and bulk erosion in viscoelastic materials: numerical study |
title_sort |
Dissolution and bulk erosion in viscoelastic materials: numerical study |
author |
Azhdari, Ebrahim |
author_facet |
Azhdari, Ebrahim Ferreira, José Augusto Oliveira, Paula de Silva, Pascoal |
author_role |
author |
author2 |
Ferreira, José Augusto Oliveira, Paula de Silva, Pascoal |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Azhdari, Ebrahim Ferreira, José Augusto Oliveira, Paula de Silva, Pascoal |
description |
A mathematical model to simulate drug delivery from a vicoelastic erodible matrix is presented in this paper. The drug is initially distributed in the matrix which is in contact with water. The entrance of water in the material changes the molecular weight and bulk erosion can be developed depending on how fast is this entrance and how fast degradation occurs. The viscoelastic properties of the matrix also change in the presence of water as the molecular weight changes. The model is represented by a system of quasi linear partial differential equations that take into account different phenomena: the uptake of water, the decreasing of the molecular weight, the viscolestic behaviour, the dissolution of the solid drug and the delivery of the dissolved drug. Numerical simulations illustrating the behaviour of the model are included. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10316/44947 http://hdl.handle.net/10316/44947 |
url |
http://hdl.handle.net/10316/44947 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
978-84-616-9216-3 http://cmmse.usal.es/cmmse2018/sites/default/files/volumes/Proceedings%20CMMSE-2014-volume1.pdf |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
J. Vigo - Aguiar |
publisher.none.fl_str_mv |
J. Vigo - Aguiar |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
|
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1799133822279745536 |