Mimicking nature: fabrication of 3D anisotropic electrospun polycaprolactone scaffolds for cartilage tissue engineering applications

Detalhes bibliográficos
Autor(a) principal: Girão, André F.
Data de Publicação: 2018
Outros Autores: Semitela, Ângela, Ramalho, Gonçalo, Completo, António, Marques, Paula A. A. P.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10773/25506
Resumo: There is a growing need to develop strategies capable of engineering the anisotropic cartilaginous fibrous network in vitro and consequently overcome the anatomical and functional restrictions of the standard medical procedures used for cartilage regeneration. In this work, we suggest a fabrication procedure to build 3D anisotropic multi-layered fibrous scaffolds. Polycaprolactone (PCL) was used as bulk material for the different electrospun layers (horizontally, randomly and vertically aligned) that were assembled and then structurally maintained by a biocompatible graphene-oxide-collagen (GO-collagen) microporous network. To validate the resourcefulness of the technique, four PCL-GO-collagen scaffolds with different anisotropic properties were produced and characterized by analysing their depth dependent morphological and mechanical properties.
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spelling Mimicking nature: fabrication of 3D anisotropic electrospun polycaprolactone scaffolds for cartilage tissue engineering applicationsCartilage tissue engineeringBiomimeticsElectrospinningAnisotropic scaffoldsThere is a growing need to develop strategies capable of engineering the anisotropic cartilaginous fibrous network in vitro and consequently overcome the anatomical and functional restrictions of the standard medical procedures used for cartilage regeneration. In this work, we suggest a fabrication procedure to build 3D anisotropic multi-layered fibrous scaffolds. Polycaprolactone (PCL) was used as bulk material for the different electrospun layers (horizontally, randomly and vertically aligned) that were assembled and then structurally maintained by a biocompatible graphene-oxide-collagen (GO-collagen) microporous network. To validate the resourcefulness of the technique, four PCL-GO-collagen scaffolds with different anisotropic properties were produced and characterized by analysing their depth dependent morphological and mechanical properties.Elsevier2019-03-07T14:01:45Z2018-12-01T00:00:00Z2018-12-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10773/25506eng1359-836810.1016/j.compositesb.2018.08.001Girão, André F.Semitela, ÂngelaRamalho, GonçaloCompleto, AntónioMarques, Paula A. A. P.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-02-22T11:49:33Zoai:ria.ua.pt:10773/25506Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T02:58:46.204100Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Mimicking nature: fabrication of 3D anisotropic electrospun polycaprolactone scaffolds for cartilage tissue engineering applications
title Mimicking nature: fabrication of 3D anisotropic electrospun polycaprolactone scaffolds for cartilage tissue engineering applications
spellingShingle Mimicking nature: fabrication of 3D anisotropic electrospun polycaprolactone scaffolds for cartilage tissue engineering applications
Girão, André F.
Cartilage tissue engineering
Biomimetics
Electrospinning
Anisotropic scaffolds
title_short Mimicking nature: fabrication of 3D anisotropic electrospun polycaprolactone scaffolds for cartilage tissue engineering applications
title_full Mimicking nature: fabrication of 3D anisotropic electrospun polycaprolactone scaffolds for cartilage tissue engineering applications
title_fullStr Mimicking nature: fabrication of 3D anisotropic electrospun polycaprolactone scaffolds for cartilage tissue engineering applications
title_full_unstemmed Mimicking nature: fabrication of 3D anisotropic electrospun polycaprolactone scaffolds for cartilage tissue engineering applications
title_sort Mimicking nature: fabrication of 3D anisotropic electrospun polycaprolactone scaffolds for cartilage tissue engineering applications
author Girão, André F.
author_facet Girão, André F.
Semitela, Ângela
Ramalho, Gonçalo
Completo, António
Marques, Paula A. A. P.
author_role author
author2 Semitela, Ângela
Ramalho, Gonçalo
Completo, António
Marques, Paula A. A. P.
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Girão, André F.
Semitela, Ângela
Ramalho, Gonçalo
Completo, António
Marques, Paula A. A. P.
dc.subject.por.fl_str_mv Cartilage tissue engineering
Biomimetics
Electrospinning
Anisotropic scaffolds
topic Cartilage tissue engineering
Biomimetics
Electrospinning
Anisotropic scaffolds
description There is a growing need to develop strategies capable of engineering the anisotropic cartilaginous fibrous network in vitro and consequently overcome the anatomical and functional restrictions of the standard medical procedures used for cartilage regeneration. In this work, we suggest a fabrication procedure to build 3D anisotropic multi-layered fibrous scaffolds. Polycaprolactone (PCL) was used as bulk material for the different electrospun layers (horizontally, randomly and vertically aligned) that were assembled and then structurally maintained by a biocompatible graphene-oxide-collagen (GO-collagen) microporous network. To validate the resourcefulness of the technique, four PCL-GO-collagen scaffolds with different anisotropic properties were produced and characterized by analysing their depth dependent morphological and mechanical properties.
publishDate 2018
dc.date.none.fl_str_mv 2018-12-01T00:00:00Z
2018-12-01
2019-03-07T14:01:45Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10773/25506
url http://hdl.handle.net/10773/25506
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1359-8368
10.1016/j.compositesb.2018.08.001
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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