Spine-Ghost: A New Bioactive Cement for Vertebroplasty

Detalhes bibliográficos
Autor(a) principal: Vitale-Brovarone, Chiara
Data de Publicação: 2015
Outros Autores: Pontirolli, Lucia, Novajra, Giorgia, Tcacencu, Ion, Reis, Joana, Manca, Antonio
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10174/12492
Resumo: An innovative, resorbable and injectable composite cement (Spine-Ghost) to be used for augmentation and restoration of fractured vertebrae was developed. Type III α-calcium sulfate hemihydrate (CSH) was selected as the bioresorbable matrix, while spray-dried mesoporous bioactive particles (SD-MBP, composition 80/20% mol SiO2/CaO), were added to impart high bioactive properties to the cement; a glass-ceramic containing zirconia was chosen as a second dispersed phase, in order to increase the radiopacity of the material. After mixing with water, an injectable paste was obtained. The developed cement proved to be mechanically compatible with healthy cancellous bone, resorbable and bioactive by soaking in simulated body fluid (SBF), cytocompatible through in-vitro cell cultures and it could be injected in ex-vivo sheep vertebra. Comparisons with a commercial control were carried out.
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spelling Spine-Ghost: A New Bioactive Cement for Vertebroplastyvertebroplastyresorbable cementmesoporous bioactive glassspray-dryingAn innovative, resorbable and injectable composite cement (Spine-Ghost) to be used for augmentation and restoration of fractured vertebrae was developed. Type III α-calcium sulfate hemihydrate (CSH) was selected as the bioresorbable matrix, while spray-dried mesoporous bioactive particles (SD-MBP, composition 80/20% mol SiO2/CaO), were added to impart high bioactive properties to the cement; a glass-ceramic containing zirconia was chosen as a second dispersed phase, in order to increase the radiopacity of the material. After mixing with water, an injectable paste was obtained. The developed cement proved to be mechanically compatible with healthy cancellous bone, resorbable and bioactive by soaking in simulated body fluid (SBF), cytocompatible through in-vitro cell cultures and it could be injected in ex-vivo sheep vertebra. Comparisons with a commercial control were carried out.Key Engineering Materials2015-01-22T12:11:45Z2015-01-222015-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10174/12492http://hdl.handle.net/10174/12492engVitale-Brovarone, C, Pontirolli L, Novajra, G, Tcacencu, I, Reis, J & Manca, A (2015): Spine-Ghost: a new bioactive Cement for Vertebroplasty. Key Engineering Materials 631 (26): 43-47.http://www.scientific.net/KEM.631.43ndndndndjmfcr@uevora.ptnd458Vitale-Brovarone, ChiaraPontirolli, LuciaNovajra, GiorgiaTcacencu, IonReis, JoanaManca, Antonioinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-01-03T18:56:49Zoai:dspace.uevora.pt:10174/12492Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T01:05:54.476598Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Spine-Ghost: A New Bioactive Cement for Vertebroplasty
title Spine-Ghost: A New Bioactive Cement for Vertebroplasty
spellingShingle Spine-Ghost: A New Bioactive Cement for Vertebroplasty
Vitale-Brovarone, Chiara
vertebroplasty
resorbable cement
mesoporous bioactive glass
spray-drying
title_short Spine-Ghost: A New Bioactive Cement for Vertebroplasty
title_full Spine-Ghost: A New Bioactive Cement for Vertebroplasty
title_fullStr Spine-Ghost: A New Bioactive Cement for Vertebroplasty
title_full_unstemmed Spine-Ghost: A New Bioactive Cement for Vertebroplasty
title_sort Spine-Ghost: A New Bioactive Cement for Vertebroplasty
author Vitale-Brovarone, Chiara
author_facet Vitale-Brovarone, Chiara
Pontirolli, Lucia
Novajra, Giorgia
Tcacencu, Ion
Reis, Joana
Manca, Antonio
author_role author
author2 Pontirolli, Lucia
Novajra, Giorgia
Tcacencu, Ion
Reis, Joana
Manca, Antonio
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Vitale-Brovarone, Chiara
Pontirolli, Lucia
Novajra, Giorgia
Tcacencu, Ion
Reis, Joana
Manca, Antonio
dc.subject.por.fl_str_mv vertebroplasty
resorbable cement
mesoporous bioactive glass
spray-drying
topic vertebroplasty
resorbable cement
mesoporous bioactive glass
spray-drying
description An innovative, resorbable and injectable composite cement (Spine-Ghost) to be used for augmentation and restoration of fractured vertebrae was developed. Type III α-calcium sulfate hemihydrate (CSH) was selected as the bioresorbable matrix, while spray-dried mesoporous bioactive particles (SD-MBP, composition 80/20% mol SiO2/CaO), were added to impart high bioactive properties to the cement; a glass-ceramic containing zirconia was chosen as a second dispersed phase, in order to increase the radiopacity of the material. After mixing with water, an injectable paste was obtained. The developed cement proved to be mechanically compatible with healthy cancellous bone, resorbable and bioactive by soaking in simulated body fluid (SBF), cytocompatible through in-vitro cell cultures and it could be injected in ex-vivo sheep vertebra. Comparisons with a commercial control were carried out.
publishDate 2015
dc.date.none.fl_str_mv 2015-01-22T12:11:45Z
2015-01-22
2015-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10174/12492
http://hdl.handle.net/10174/12492
url http://hdl.handle.net/10174/12492
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Vitale-Brovarone, C, Pontirolli L, Novajra, G, Tcacencu, I, Reis, J & Manca, A (2015): Spine-Ghost: a new bioactive Cement for Vertebroplasty. Key Engineering Materials 631 (26): 43-47.
http://www.scientific.net/KEM.631.43
nd
nd
nd
nd
jmfcr@uevora.pt
nd
458
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Key Engineering Materials
publisher.none.fl_str_mv Key Engineering Materials
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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