Neural Mechanisms of Exercise: Anti-Depression, Neurogenesis, and Serotonin Signaling

Detalhes bibliográficos
Autor(a) principal: Yuan, Ti-Fei
Data de Publicação: 2015
Outros Autores: Paes, Flávia, Arias-Carrión, Oscar, Rocha, Nuno, de Sá Filho, Alberto Souza, Machado, Sergio
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.22/7537
Resumo: Depression is associated with decreased serotonin metabolism and functioning in the central nervous system, evidenced by both animal models of depression and clinical patient studies. Depression is also accompanied by decreased hippocampal neurogenesis in diverse animal models. Neurogenesis is mainly defined in dentate gyrus of hippocampus as well as subventricular zone. Moreover, hypothalamus, amygdala, olfactory tubercle, and piriform cortex are reported with evidences of adult neurogenesis. Physical exercise is found to modulate adult neurogenesis significantly, and results in mood improvement. The cellular mechanism such as adult neurogenesis upregulation was considered as one major mood regulator following exercise. The recent advances in molecular mechanisms underlying exercise-regulated neurogenesis have widen our understanding in brain plasticity in physiological and pathological conditions, and therefore better management of different psychiatric disorders.
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spelling Neural Mechanisms of Exercise: Anti-Depression, Neurogenesis, and Serotonin SignalingserotoninneurogenesisExercisedepressionDepression is associated with decreased serotonin metabolism and functioning in the central nervous system, evidenced by both animal models of depression and clinical patient studies. Depression is also accompanied by decreased hippocampal neurogenesis in diverse animal models. Neurogenesis is mainly defined in dentate gyrus of hippocampus as well as subventricular zone. Moreover, hypothalamus, amygdala, olfactory tubercle, and piriform cortex are reported with evidences of adult neurogenesis. Physical exercise is found to modulate adult neurogenesis significantly, and results in mood improvement. The cellular mechanism such as adult neurogenesis upregulation was considered as one major mood regulator following exercise. The recent advances in molecular mechanisms underlying exercise-regulated neurogenesis have widen our understanding in brain plasticity in physiological and pathological conditions, and therefore better management of different psychiatric disorders.Repositório Científico do Instituto Politécnico do PortoYuan, Ti-FeiPaes, FláviaArias-Carrión, OscarRocha, Nunode Sá Filho, Alberto SouzaMachado, Sergio2016-01-27T12:35:07Z20152015-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.22/7537eng10.2174/1871527315666151111124543info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-13T12:47:48Zoai:recipp.ipp.pt:10400.22/7537Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:27:50.173859Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Neural Mechanisms of Exercise: Anti-Depression, Neurogenesis, and Serotonin Signaling
title Neural Mechanisms of Exercise: Anti-Depression, Neurogenesis, and Serotonin Signaling
spellingShingle Neural Mechanisms of Exercise: Anti-Depression, Neurogenesis, and Serotonin Signaling
Yuan, Ti-Fei
serotonin
neurogenesis
Exercise
depression
title_short Neural Mechanisms of Exercise: Anti-Depression, Neurogenesis, and Serotonin Signaling
title_full Neural Mechanisms of Exercise: Anti-Depression, Neurogenesis, and Serotonin Signaling
title_fullStr Neural Mechanisms of Exercise: Anti-Depression, Neurogenesis, and Serotonin Signaling
title_full_unstemmed Neural Mechanisms of Exercise: Anti-Depression, Neurogenesis, and Serotonin Signaling
title_sort Neural Mechanisms of Exercise: Anti-Depression, Neurogenesis, and Serotonin Signaling
author Yuan, Ti-Fei
author_facet Yuan, Ti-Fei
Paes, Flávia
Arias-Carrión, Oscar
Rocha, Nuno
de Sá Filho, Alberto Souza
Machado, Sergio
author_role author
author2 Paes, Flávia
Arias-Carrión, Oscar
Rocha, Nuno
de Sá Filho, Alberto Souza
Machado, Sergio
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório Científico do Instituto Politécnico do Porto
dc.contributor.author.fl_str_mv Yuan, Ti-Fei
Paes, Flávia
Arias-Carrión, Oscar
Rocha, Nuno
de Sá Filho, Alberto Souza
Machado, Sergio
dc.subject.por.fl_str_mv serotonin
neurogenesis
Exercise
depression
topic serotonin
neurogenesis
Exercise
depression
description Depression is associated with decreased serotonin metabolism and functioning in the central nervous system, evidenced by both animal models of depression and clinical patient studies. Depression is also accompanied by decreased hippocampal neurogenesis in diverse animal models. Neurogenesis is mainly defined in dentate gyrus of hippocampus as well as subventricular zone. Moreover, hypothalamus, amygdala, olfactory tubercle, and piriform cortex are reported with evidences of adult neurogenesis. Physical exercise is found to modulate adult neurogenesis significantly, and results in mood improvement. The cellular mechanism such as adult neurogenesis upregulation was considered as one major mood regulator following exercise. The recent advances in molecular mechanisms underlying exercise-regulated neurogenesis have widen our understanding in brain plasticity in physiological and pathological conditions, and therefore better management of different psychiatric disorders.
publishDate 2015
dc.date.none.fl_str_mv 2015
2015-01-01T00:00:00Z
2016-01-27T12:35:07Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.22/7537
url http://hdl.handle.net/10400.22/7537
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.2174/1871527315666151111124543
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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