Bioactive phenolic compounds action in anti-proliferative and anti-inflammatory activity
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Tipo de documento: | Dissertação |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10348/9937 |
Resumo: | This study is focused on three main flavonoids compounds: Kaempferol, which is isolated from several natural plants, it is a polyphenol belonging to the subgroup of flavonoids, it exhibits various pharmacological activities, including anti-inflammatory, antioxidant, antimicrobial, and anticancer activities; Quercetin which is a polyphenolic flavonoid with potential chemopreventive activity, ubiquitous in plant food sources and a major bioflavonoid in the human diet, it also produces anti-inflammatory and anti-allergy effects mediated through the inhibition of the lipoxygenase and cyclooxygenase pathways, thereby preventing the production of pro-inflammatory mediators and Eriodictyol which is a flavonoid with anti-inflammatory and antioxidant activities. Because inflammation and oxidative stress play critical roles in the pathogenesis of diabetes mellitus, the present study was designed to explore whether Eriodictyol, Quercetin and Kaempferol have therapeutic potential for the treatment of common diseases. In this study we studied the anti-proliferative effect of the three flavonoids using RAW 246.7 cells as in vitro model, and observed a dose-dependent reduction in cell viability. We also evaluated the capacity of these flavonoids to inhibit, in vitro, the activity of selected enzymes to assess their potential use as anti-aging, neuroprotective and anti-diabetic agents. |
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Bioactive phenolic compounds action in anti-proliferative and anti-inflammatory activityCell BiologyBiomedical applicationsThis study is focused on three main flavonoids compounds: Kaempferol, which is isolated from several natural plants, it is a polyphenol belonging to the subgroup of flavonoids, it exhibits various pharmacological activities, including anti-inflammatory, antioxidant, antimicrobial, and anticancer activities; Quercetin which is a polyphenolic flavonoid with potential chemopreventive activity, ubiquitous in plant food sources and a major bioflavonoid in the human diet, it also produces anti-inflammatory and anti-allergy effects mediated through the inhibition of the lipoxygenase and cyclooxygenase pathways, thereby preventing the production of pro-inflammatory mediators and Eriodictyol which is a flavonoid with anti-inflammatory and antioxidant activities. Because inflammation and oxidative stress play critical roles in the pathogenesis of diabetes mellitus, the present study was designed to explore whether Eriodictyol, Quercetin and Kaempferol have therapeutic potential for the treatment of common diseases. In this study we studied the anti-proliferative effect of the three flavonoids using RAW 246.7 cells as in vitro model, and observed a dose-dependent reduction in cell viability. We also evaluated the capacity of these flavonoids to inhibit, in vitro, the activity of selected enzymes to assess their potential use as anti-aging, neuroprotective and anti-diabetic agents.Este estudo focou-se em três compostos flavonóides: o Kaempferol, isolado de várias plantas naturais; é um polifenol pertencente ao subgrupo de flavonóides; exibe várias atividades farmacológicas, incluindo atividades anti-inflamatórias, antioxidantes, antimicrobianas e anticancerígeno; A quercetina, que é um flavonóide polifenólico com potencial atividade químio-preventiva, onipresente em fontes alimentares de plantas e um dos principais bioflavonóides da dieta humana, também produz efeitos anti-inflamatórios e antialérgicos mediados pela inibição das vias lipoxigenase e ciclooxigenase, impedindo assim a produção de mediadores pró-inflamatórios e eriodictyol, que é um flavonóide com atividades anti-inflamatórias e antioxidantes. Como a inflamação e o estresse oxidativo desempenham papéis críticos na patogênese do diabetes mellitus, o presente estudo foi desenvolvido para explorar se o eriodictyol, a quercetina e o Kaempferol têm potencial terapêutico para o tratamento de doenças comuns. Neste estudo, estudamos o efeito anti-proliferativo dos três flavonóides usando células RAW 246.7 como modelo in vitro, e observamos uma redução dependente da dose na viabilidade celular. Também avaliamos a capacidade desses flavonóides de inibir, in vitro, a atividade de enzimas selecionadas para avaliar seu potencial uso como agentes anti-envelhecimento, neuroprotetor e antidiabético2020-06-04T10:17:47Z2020-03-03T00:00:00Z2020-03-03info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/10348/9937engMorais, Adriano José Sousainfo:eu-repo/semantics/embargoedAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-02-02T12:38:34Zoai:repositorio.utad.pt:10348/9937Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T02:02:03.114343Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Bioactive phenolic compounds action in anti-proliferative and anti-inflammatory activity |
title |
Bioactive phenolic compounds action in anti-proliferative and anti-inflammatory activity |
spellingShingle |
Bioactive phenolic compounds action in anti-proliferative and anti-inflammatory activity Morais, Adriano José Sousa Cell Biology Biomedical applications |
title_short |
Bioactive phenolic compounds action in anti-proliferative and anti-inflammatory activity |
title_full |
Bioactive phenolic compounds action in anti-proliferative and anti-inflammatory activity |
title_fullStr |
Bioactive phenolic compounds action in anti-proliferative and anti-inflammatory activity |
title_full_unstemmed |
Bioactive phenolic compounds action in anti-proliferative and anti-inflammatory activity |
title_sort |
Bioactive phenolic compounds action in anti-proliferative and anti-inflammatory activity |
author |
Morais, Adriano José Sousa |
author_facet |
Morais, Adriano José Sousa |
author_role |
author |
dc.contributor.author.fl_str_mv |
Morais, Adriano José Sousa |
dc.subject.por.fl_str_mv |
Cell Biology Biomedical applications |
topic |
Cell Biology Biomedical applications |
description |
This study is focused on three main flavonoids compounds: Kaempferol, which is isolated from several natural plants, it is a polyphenol belonging to the subgroup of flavonoids, it exhibits various pharmacological activities, including anti-inflammatory, antioxidant, antimicrobial, and anticancer activities; Quercetin which is a polyphenolic flavonoid with potential chemopreventive activity, ubiquitous in plant food sources and a major bioflavonoid in the human diet, it also produces anti-inflammatory and anti-allergy effects mediated through the inhibition of the lipoxygenase and cyclooxygenase pathways, thereby preventing the production of pro-inflammatory mediators and Eriodictyol which is a flavonoid with anti-inflammatory and antioxidant activities. Because inflammation and oxidative stress play critical roles in the pathogenesis of diabetes mellitus, the present study was designed to explore whether Eriodictyol, Quercetin and Kaempferol have therapeutic potential for the treatment of common diseases. In this study we studied the anti-proliferative effect of the three flavonoids using RAW 246.7 cells as in vitro model, and observed a dose-dependent reduction in cell viability. We also evaluated the capacity of these flavonoids to inhibit, in vitro, the activity of selected enzymes to assess their potential use as anti-aging, neuroprotective and anti-diabetic agents. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-06-04T10:17:47Z 2020-03-03T00:00:00Z 2020-03-03 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10348/9937 |
url |
http://hdl.handle.net/10348/9937 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/embargoedAccess |
eu_rights_str_mv |
embargoedAccess |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799137105094377472 |