Interplay between depressive-like behavior and the immune system in an animal model of prenatal dexamethasone administration
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/18707 |
Resumo: | Glucocorticoids, namely dexamethasone, are prescribed during late gestation in pregnancies at risk of originating premature newborns, to promote fetal lung maturation. However, adverse early life events have been reported to induce long-lasting changes in the immune and central nervous systems. The accumulating evidence on bidirectional interactions between both systems in psychiatric disorders like depression, prompted us to further investigate the long-term impact of prenatal dexamethasone administration in depressive-like behavior, the immune system and in the ability to mount an immune response to acute infection. The adult male offspring of pregnant dams treated with dexamethasone present depressive-like behavior concomitant with a decrease in CD8+ T lymphocytes and an increase in B and CD4+ regulatory T cells. This is accompanied by lower levels of serum interleukin-6 (IL-6) and IL-10. Despite of these differences, when spleen cells are stimulated, in vitro, with lipopolysaccharide, those from adult rats prenatally treated with dexamethasone display a stronger pro-inflammatory cytokine response. However, this immune system profile does not hamper the ability of rats prenatally treated with dexamethasone to respond to acute infection by Listeria monocytogenes. Of notice, L. monocytogenes infection triggers depressive-like behavior in control animals but does not worsen that already present in dexamethasone-treated animals. In summary, prenatal administration of dexamethasone has long-lasting effects on the immune system and on behavior, which are not further aggravated by acute infection with L. monocytogenes. |
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Interplay between depressive-like behavior and the immune system in an animal model of prenatal dexamethasone administrationPrenatalDexamethasoneImmunityBehaviorDepressionListeria monocytogenesScience & TechnologyGlucocorticoids, namely dexamethasone, are prescribed during late gestation in pregnancies at risk of originating premature newborns, to promote fetal lung maturation. However, adverse early life events have been reported to induce long-lasting changes in the immune and central nervous systems. The accumulating evidence on bidirectional interactions between both systems in psychiatric disorders like depression, prompted us to further investigate the long-term impact of prenatal dexamethasone administration in depressive-like behavior, the immune system and in the ability to mount an immune response to acute infection. The adult male offspring of pregnant dams treated with dexamethasone present depressive-like behavior concomitant with a decrease in CD8+ T lymphocytes and an increase in B and CD4+ regulatory T cells. This is accompanied by lower levels of serum interleukin-6 (IL-6) and IL-10. Despite of these differences, when spleen cells are stimulated, in vitro, with lipopolysaccharide, those from adult rats prenatally treated with dexamethasone display a stronger pro-inflammatory cytokine response. However, this immune system profile does not hamper the ability of rats prenatally treated with dexamethasone to respond to acute infection by Listeria monocytogenes. Of notice, L. monocytogenes infection triggers depressive-like behavior in control animals but does not worsen that already present in dexamethasone-treated animals. In summary, prenatal administration of dexamethasone has long-lasting effects on the immune system and on behavior, which are not further aggravated by acute infection with L. monocytogenes.We acknowledge the Portuguese Foundation for Science and Technology (FCT) for providing a fellowship to Susana Roque (SFRH/BD/24539/2005), Claudia Nobrega (SFRH/BPD/65380/2009), and Claudio Nunes-Alves (SFRH/BD/38614/2007). This work was also supported by a FCT grant PTDC/SAU-NEU/105180/2008.Frontiers MediaUniversidade do MinhoRoque, SusanaOliveira, Tiago GilNóbrega, CláudiaSilva, Palmira Conceição Araújo BarreiraAlves, Cláudio NunesSousa, NunoPalha, Joana AlmeidaNeves, Margarida Correia2011-022011-02-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/18707eng1662-515310.3389/fnbeh.2011.00004http://www.frontiersin.org/info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:24:53Zoai:repositorium.sdum.uminho.pt:1822/18707Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:19:00.818700Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Interplay between depressive-like behavior and the immune system in an animal model of prenatal dexamethasone administration |
title |
Interplay between depressive-like behavior and the immune system in an animal model of prenatal dexamethasone administration |
spellingShingle |
Interplay between depressive-like behavior and the immune system in an animal model of prenatal dexamethasone administration Roque, Susana Prenatal Dexamethasone Immunity Behavior Depression Listeria monocytogenes Science & Technology |
title_short |
Interplay between depressive-like behavior and the immune system in an animal model of prenatal dexamethasone administration |
title_full |
Interplay between depressive-like behavior and the immune system in an animal model of prenatal dexamethasone administration |
title_fullStr |
Interplay between depressive-like behavior and the immune system in an animal model of prenatal dexamethasone administration |
title_full_unstemmed |
Interplay between depressive-like behavior and the immune system in an animal model of prenatal dexamethasone administration |
title_sort |
Interplay between depressive-like behavior and the immune system in an animal model of prenatal dexamethasone administration |
author |
Roque, Susana |
author_facet |
Roque, Susana Oliveira, Tiago Gil Nóbrega, Cláudia Silva, Palmira Conceição Araújo Barreira Alves, Cláudio Nunes Sousa, Nuno Palha, Joana Almeida Neves, Margarida Correia |
author_role |
author |
author2 |
Oliveira, Tiago Gil Nóbrega, Cláudia Silva, Palmira Conceição Araújo Barreira Alves, Cláudio Nunes Sousa, Nuno Palha, Joana Almeida Neves, Margarida Correia |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Roque, Susana Oliveira, Tiago Gil Nóbrega, Cláudia Silva, Palmira Conceição Araújo Barreira Alves, Cláudio Nunes Sousa, Nuno Palha, Joana Almeida Neves, Margarida Correia |
dc.subject.por.fl_str_mv |
Prenatal Dexamethasone Immunity Behavior Depression Listeria monocytogenes Science & Technology |
topic |
Prenatal Dexamethasone Immunity Behavior Depression Listeria monocytogenes Science & Technology |
description |
Glucocorticoids, namely dexamethasone, are prescribed during late gestation in pregnancies at risk of originating premature newborns, to promote fetal lung maturation. However, adverse early life events have been reported to induce long-lasting changes in the immune and central nervous systems. The accumulating evidence on bidirectional interactions between both systems in psychiatric disorders like depression, prompted us to further investigate the long-term impact of prenatal dexamethasone administration in depressive-like behavior, the immune system and in the ability to mount an immune response to acute infection. The adult male offspring of pregnant dams treated with dexamethasone present depressive-like behavior concomitant with a decrease in CD8+ T lymphocytes and an increase in B and CD4+ regulatory T cells. This is accompanied by lower levels of serum interleukin-6 (IL-6) and IL-10. Despite of these differences, when spleen cells are stimulated, in vitro, with lipopolysaccharide, those from adult rats prenatally treated with dexamethasone display a stronger pro-inflammatory cytokine response. However, this immune system profile does not hamper the ability of rats prenatally treated with dexamethasone to respond to acute infection by Listeria monocytogenes. Of notice, L. monocytogenes infection triggers depressive-like behavior in control animals but does not worsen that already present in dexamethasone-treated animals. In summary, prenatal administration of dexamethasone has long-lasting effects on the immune system and on behavior, which are not further aggravated by acute infection with L. monocytogenes. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011-02 2011-02-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/18707 |
url |
http://hdl.handle.net/1822/18707 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
1662-5153 10.3389/fnbeh.2011.00004 http://www.frontiersin.org/ |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Frontiers Media |
publisher.none.fl_str_mv |
Frontiers Media |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799132647246528512 |