Molecular Imprinting of Complex Matrices at Localized Surface Plasmon Resonance Biosensors for Screening of Global Interactions of Polyphenols and Proteins

Detalhes bibliográficos
Autor(a) principal: Guerreiro, Joana Rafaela Lara
Data de Publicação: 2016
Outros Autores: Bochenkov, Vladimir E., Runager, Kasper, Aslan, Hüsnü, Dong, Mingdong, Enghild, Jan J., Freitas, Victor de, Sales, M. Goreti F., Sutherland, Duncan S.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.22/10040
Resumo: Molecular imprinting polymers (MIP) have been applied to capture and stabilize complex protein matrices at plasmonic sensor surfaces. Ultrathin MIP layers at the surface of gold nanodisks enable the label free quantification of global interactions of polyphenols with protein mixtures. Separate polyphenols (catechin, procyanidin B3- catechin dimer, and PGG-pentagalloyl glucose) give specific and different binding levels to the MIP supported saliva plasmonic sensor. The demonstrated biosensor has application to study bioavailability of polyphenols or evaluation of local retention of small drug molecules.
id RCAP_e3c2e91a0eea7d5742f26aec5cf34606
oai_identifier_str oai:recipp.ipp.pt:10400.22/10040
network_acronym_str RCAP
network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str 7160
spelling Molecular Imprinting of Complex Matrices at Localized Surface Plasmon Resonance Biosensors for Screening of Global Interactions of Polyphenols and ProteinsLocalized surface plasmon resonance (LSPR)Molecular imprintingComplex protein matrixPolyphenolsBiosensingNanodisksMolecular imprinting polymers (MIP) have been applied to capture and stabilize complex protein matrices at plasmonic sensor surfaces. Ultrathin MIP layers at the surface of gold nanodisks enable the label free quantification of global interactions of polyphenols with protein mixtures. Separate polyphenols (catechin, procyanidin B3- catechin dimer, and PGG-pentagalloyl glucose) give specific and different binding levels to the MIP supported saliva plasmonic sensor. The demonstrated biosensor has application to study bioavailability of polyphenols or evaluation of local retention of small drug molecules.American Chemical SocietyRepositório Científico do Instituto Politécnico do PortoGuerreiro, Joana Rafaela LaraBochenkov, Vladimir E.Runager, KasperAslan, HüsnüDong, MingdongEnghild, Jan J.Freitas, Victor deSales, M. Goreti F.Sutherland, Duncan S.2017-07-13T11:13:32Z20162016-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.22/10040eng10.1021/acssensors.5b00054info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-13T12:51:32Zoai:recipp.ipp.pt:10400.22/10040Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:30:30.694065Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Molecular Imprinting of Complex Matrices at Localized Surface Plasmon Resonance Biosensors for Screening of Global Interactions of Polyphenols and Proteins
title Molecular Imprinting of Complex Matrices at Localized Surface Plasmon Resonance Biosensors for Screening of Global Interactions of Polyphenols and Proteins
spellingShingle Molecular Imprinting of Complex Matrices at Localized Surface Plasmon Resonance Biosensors for Screening of Global Interactions of Polyphenols and Proteins
Guerreiro, Joana Rafaela Lara
Localized surface plasmon resonance (LSPR)
Molecular imprinting
Complex protein matrix
Polyphenols
Biosensing
Nanodisks
title_short Molecular Imprinting of Complex Matrices at Localized Surface Plasmon Resonance Biosensors for Screening of Global Interactions of Polyphenols and Proteins
title_full Molecular Imprinting of Complex Matrices at Localized Surface Plasmon Resonance Biosensors for Screening of Global Interactions of Polyphenols and Proteins
title_fullStr Molecular Imprinting of Complex Matrices at Localized Surface Plasmon Resonance Biosensors for Screening of Global Interactions of Polyphenols and Proteins
title_full_unstemmed Molecular Imprinting of Complex Matrices at Localized Surface Plasmon Resonance Biosensors for Screening of Global Interactions of Polyphenols and Proteins
title_sort Molecular Imprinting of Complex Matrices at Localized Surface Plasmon Resonance Biosensors for Screening of Global Interactions of Polyphenols and Proteins
author Guerreiro, Joana Rafaela Lara
author_facet Guerreiro, Joana Rafaela Lara
Bochenkov, Vladimir E.
Runager, Kasper
Aslan, Hüsnü
Dong, Mingdong
Enghild, Jan J.
Freitas, Victor de
Sales, M. Goreti F.
Sutherland, Duncan S.
author_role author
author2 Bochenkov, Vladimir E.
Runager, Kasper
Aslan, Hüsnü
Dong, Mingdong
Enghild, Jan J.
Freitas, Victor de
Sales, M. Goreti F.
Sutherland, Duncan S.
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório Científico do Instituto Politécnico do Porto
dc.contributor.author.fl_str_mv Guerreiro, Joana Rafaela Lara
Bochenkov, Vladimir E.
Runager, Kasper
Aslan, Hüsnü
Dong, Mingdong
Enghild, Jan J.
Freitas, Victor de
Sales, M. Goreti F.
Sutherland, Duncan S.
dc.subject.por.fl_str_mv Localized surface plasmon resonance (LSPR)
Molecular imprinting
Complex protein matrix
Polyphenols
Biosensing
Nanodisks
topic Localized surface plasmon resonance (LSPR)
Molecular imprinting
Complex protein matrix
Polyphenols
Biosensing
Nanodisks
description Molecular imprinting polymers (MIP) have been applied to capture and stabilize complex protein matrices at plasmonic sensor surfaces. Ultrathin MIP layers at the surface of gold nanodisks enable the label free quantification of global interactions of polyphenols with protein mixtures. Separate polyphenols (catechin, procyanidin B3- catechin dimer, and PGG-pentagalloyl glucose) give specific and different binding levels to the MIP supported saliva plasmonic sensor. The demonstrated biosensor has application to study bioavailability of polyphenols or evaluation of local retention of small drug molecules.
publishDate 2016
dc.date.none.fl_str_mv 2016
2016-01-01T00:00:00Z
2017-07-13T11:13:32Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.22/10040
url http://hdl.handle.net/10400.22/10040
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1021/acssensors.5b00054
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv American Chemical Society
publisher.none.fl_str_mv American Chemical Society
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
_version_ 1799131400717205504

Registros relacionados