Signaling mechanisms in mammalian sperm motility

Detalhes bibliográficos
Autor(a) principal: Freitas, Maria João
Data de Publicação: 2017
Outros Autores: Vijayaraghavan, Srinivasan, Fardilha, Margarida
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10773/29560
Resumo: The goal of sperm is to fertilize the oocyte. To achieve that purpose, it must acquire motility in the epididymis and hyperactivated motility in the female reproductive tract. Motility is only achieved when the sperm presents a fully functional flagellum, is capable of producing energy to fuel the movement, and suffers epididymal maturation and capacitation. Since sperm is a transcriptionally silent cell, motility depends on the activation and/or inhibitions of key signaling pathways. This review describes and discusses the main signaling pathways involved in primary and hyperactivated motility, as well as the bioenergetic mechanisms necessary to produce energy to fuel sperm motility. Although the complete human sperm motility process is far from being fully known, we believe that in the upcoming decades extensive progress will be made. Understanding the signaling pathways behind sperm motility can help pinpoint the cause of male infertility and uncover targets for male contraception.
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spelling Signaling mechanisms in mammalian sperm motilitySperm motilitySignaling pathwaysPhosphorylationEpididymisFemale reproductive systemThe goal of sperm is to fertilize the oocyte. To achieve that purpose, it must acquire motility in the epididymis and hyperactivated motility in the female reproductive tract. Motility is only achieved when the sperm presents a fully functional flagellum, is capable of producing energy to fuel the movement, and suffers epididymal maturation and capacitation. Since sperm is a transcriptionally silent cell, motility depends on the activation and/or inhibitions of key signaling pathways. This review describes and discusses the main signaling pathways involved in primary and hyperactivated motility, as well as the bioenergetic mechanisms necessary to produce energy to fuel sperm motility. Although the complete human sperm motility process is far from being fully known, we believe that in the upcoming decades extensive progress will be made. Understanding the signaling pathways behind sperm motility can help pinpoint the cause of male infertility and uncover targets for male contraception.Oxford University Press2020-10-22T14:06:48Z2017-01-01T00:00:00Z2017-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10773/29560eng0006-336310.1095/biolreprod.116.144337Freitas, Maria JoãoVijayaraghavan, SrinivasanFardilha, Margaridainfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-02-22T11:56:32Zoai:ria.ua.pt:10773/29560Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:01:37.062235Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Signaling mechanisms in mammalian sperm motility
title Signaling mechanisms in mammalian sperm motility
spellingShingle Signaling mechanisms in mammalian sperm motility
Freitas, Maria João
Sperm motility
Signaling pathways
Phosphorylation
Epididymis
Female reproductive system
title_short Signaling mechanisms in mammalian sperm motility
title_full Signaling mechanisms in mammalian sperm motility
title_fullStr Signaling mechanisms in mammalian sperm motility
title_full_unstemmed Signaling mechanisms in mammalian sperm motility
title_sort Signaling mechanisms in mammalian sperm motility
author Freitas, Maria João
author_facet Freitas, Maria João
Vijayaraghavan, Srinivasan
Fardilha, Margarida
author_role author
author2 Vijayaraghavan, Srinivasan
Fardilha, Margarida
author2_role author
author
dc.contributor.author.fl_str_mv Freitas, Maria João
Vijayaraghavan, Srinivasan
Fardilha, Margarida
dc.subject.por.fl_str_mv Sperm motility
Signaling pathways
Phosphorylation
Epididymis
Female reproductive system
topic Sperm motility
Signaling pathways
Phosphorylation
Epididymis
Female reproductive system
description The goal of sperm is to fertilize the oocyte. To achieve that purpose, it must acquire motility in the epididymis and hyperactivated motility in the female reproductive tract. Motility is only achieved when the sperm presents a fully functional flagellum, is capable of producing energy to fuel the movement, and suffers epididymal maturation and capacitation. Since sperm is a transcriptionally silent cell, motility depends on the activation and/or inhibitions of key signaling pathways. This review describes and discusses the main signaling pathways involved in primary and hyperactivated motility, as well as the bioenergetic mechanisms necessary to produce energy to fuel sperm motility. Although the complete human sperm motility process is far from being fully known, we believe that in the upcoming decades extensive progress will be made. Understanding the signaling pathways behind sperm motility can help pinpoint the cause of male infertility and uncover targets for male contraception.
publishDate 2017
dc.date.none.fl_str_mv 2017-01-01T00:00:00Z
2017-01
2020-10-22T14:06:48Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10773/29560
url http://hdl.handle.net/10773/29560
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0006-3363
10.1095/biolreprod.116.144337
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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