FDG Accumulation and Tumor Biology
Autor(a) principal: | |
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Data de Publicação: | 1998 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10316/4860 https://doi.org/10.1016/S0969-8051(97)00226-6 |
Resumo: | The tumoral uptake of fluorine-18-deoxyglucose (FDG) is based upon enhanced glycolysis. Following injection, FDG is phosphorylated and trapped intracellularly. An important mechanism to transport FDG into the transformed cell is based upon the action of glucose transporter proteins; furthermore, highly active hexokinase bound to tumor mitochondria helps to trap FDG into the cell. In addition, enhanced FDG uptake may be due to relative hypoxia in tumor masses, which activates the anaerobic glycolytic pathway. In spite of these processes, FDG uptake is relatively aspecific since all living cells need glucose. Clinical use is therefore recommended in carefully selected patients. |
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FDG Accumulation and Tumor BiologyScintigraphyFluorodeoxyglucoseTumor biologyThe tumoral uptake of fluorine-18-deoxyglucose (FDG) is based upon enhanced glycolysis. Following injection, FDG is phosphorylated and trapped intracellularly. An important mechanism to transport FDG into the transformed cell is based upon the action of glucose transporter proteins; furthermore, highly active hexokinase bound to tumor mitochondria helps to trap FDG into the cell. In addition, enhanced FDG uptake may be due to relative hypoxia in tumor masses, which activates the anaerobic glycolytic pathway. In spite of these processes, FDG uptake is relatively aspecific since all living cells need glucose. Clinical use is therefore recommended in carefully selected patients.http://www.sciencedirect.com/science/article/B6T9Y-3T6YJSP-R/1/fbaf3f2de58361e6bcbacfe1ec6d31991998info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleaplication/PDFhttp://hdl.handle.net/10316/4860http://hdl.handle.net/10316/4860https://doi.org/10.1016/S0969-8051(97)00226-6engNuclear Medicine and Biology. 25:4 (1998) 317-322Pauwels, E. K. J.Ribeiro, M. J.Stoot, J. H. M. B.McCready, V. R.Bourguignon, M.Mazière, B.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-05-25T01:44:32Zoai:estudogeral.uc.pt:10316/4860Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:43:29.519473Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
FDG Accumulation and Tumor Biology |
title |
FDG Accumulation and Tumor Biology |
spellingShingle |
FDG Accumulation and Tumor Biology Pauwels, E. K. J. Scintigraphy Fluorodeoxyglucose Tumor biology |
title_short |
FDG Accumulation and Tumor Biology |
title_full |
FDG Accumulation and Tumor Biology |
title_fullStr |
FDG Accumulation and Tumor Biology |
title_full_unstemmed |
FDG Accumulation and Tumor Biology |
title_sort |
FDG Accumulation and Tumor Biology |
author |
Pauwels, E. K. J. |
author_facet |
Pauwels, E. K. J. Ribeiro, M. J. Stoot, J. H. M. B. McCready, V. R. Bourguignon, M. Mazière, B. |
author_role |
author |
author2 |
Ribeiro, M. J. Stoot, J. H. M. B. McCready, V. R. Bourguignon, M. Mazière, B. |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Pauwels, E. K. J. Ribeiro, M. J. Stoot, J. H. M. B. McCready, V. R. Bourguignon, M. Mazière, B. |
dc.subject.por.fl_str_mv |
Scintigraphy Fluorodeoxyglucose Tumor biology |
topic |
Scintigraphy Fluorodeoxyglucose Tumor biology |
description |
The tumoral uptake of fluorine-18-deoxyglucose (FDG) is based upon enhanced glycolysis. Following injection, FDG is phosphorylated and trapped intracellularly. An important mechanism to transport FDG into the transformed cell is based upon the action of glucose transporter proteins; furthermore, highly active hexokinase bound to tumor mitochondria helps to trap FDG into the cell. In addition, enhanced FDG uptake may be due to relative hypoxia in tumor masses, which activates the anaerobic glycolytic pathway. In spite of these processes, FDG uptake is relatively aspecific since all living cells need glucose. Clinical use is therefore recommended in carefully selected patients. |
publishDate |
1998 |
dc.date.none.fl_str_mv |
1998 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10316/4860 http://hdl.handle.net/10316/4860 https://doi.org/10.1016/S0969-8051(97)00226-6 |
url |
http://hdl.handle.net/10316/4860 https://doi.org/10.1016/S0969-8051(97)00226-6 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Nuclear Medicine and Biology. 25:4 (1998) 317-322 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
aplication/PDF |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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