Exploiting Co(III)-Cyclopentadienyl Complexes To Develop Anticancer Agents
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2024 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10362/167690 |
Resumo: | Publisher Copyright: © 2024 The Authors. Published by American Chemical Society. |
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Exploiting Co(III)-Cyclopentadienyl Complexes To Develop Anticancer AgentsPhysical and Theoretical ChemistryInorganic ChemistrySDG 3 - Good Health and Well-beingPublisher Copyright: © 2024 The Authors. Published by American Chemical Society.In recent years, organometallic complexes have attracted much attention as anticancer therapeutics aiming at overcoming the limitations of platinum drugs that are currently marketed. Still, the development of half-sandwich organometallic cobalt complexes remains scarcely explored. Four new cobalt(III)-cyclopentadienyl complexes containing N,N-heteroaromatic bidentate, and phosphane ligands were synthesized and fully characterized by elemental analysis, spectroscopic techniques, and DFT methods. The cytotoxicity of all complexes was determined in vitro by the MTS assay in colorectal (HCT116), ovarian (A2780), and breast (MDA-MB-231 and MCF-7) human cancer cell lines and in a healthy human cell line (fibroblasts). The complexes showed high cytotoxicity in cancer cell lines, mostly due to ROS production, apoptosis, autophagy induction, and disruption of the mitochondrial membrane. Also, these complexes were shown to be nontoxic in vivo in an ex ovo chick embryo yolk sac membrane (YSM) assay.DCV - Departamento de Ciências da VidaUCIBIO - Applied Molecular Biosciences UnitRUNFranco Machado, JoãoCordeiro, SandraDuarte, Joana N.Costa, Paulo J.Mendes, Paulo J.Garcia, Maria HelenaBaptista, Pedro V.Fernandes, Alexandra R.Morais, Tânia S.2024-05-23T00:32:56Z2024-04-012024-04-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article22application/pdfhttp://hdl.handle.net/10362/167690eng0020-1669PURE: 91740979https://doi.org/10.1021/acs.inorgchem.3c03696info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-06-24T01:35:25Zoai:run.unl.pt:10362/167690Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-06-24T01:35:25Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Exploiting Co(III)-Cyclopentadienyl Complexes To Develop Anticancer Agents |
| title |
Exploiting Co(III)-Cyclopentadienyl Complexes To Develop Anticancer Agents |
| spellingShingle |
Exploiting Co(III)-Cyclopentadienyl Complexes To Develop Anticancer Agents Franco Machado, João Physical and Theoretical Chemistry Inorganic Chemistry SDG 3 - Good Health and Well-being |
| title_short |
Exploiting Co(III)-Cyclopentadienyl Complexes To Develop Anticancer Agents |
| title_full |
Exploiting Co(III)-Cyclopentadienyl Complexes To Develop Anticancer Agents |
| title_fullStr |
Exploiting Co(III)-Cyclopentadienyl Complexes To Develop Anticancer Agents |
| title_full_unstemmed |
Exploiting Co(III)-Cyclopentadienyl Complexes To Develop Anticancer Agents |
| title_sort |
Exploiting Co(III)-Cyclopentadienyl Complexes To Develop Anticancer Agents |
| author |
Franco Machado, João |
| author_facet |
Franco Machado, João Cordeiro, Sandra Duarte, Joana N. Costa, Paulo J. Mendes, Paulo J. Garcia, Maria Helena Baptista, Pedro V. Fernandes, Alexandra R. Morais, Tânia S. |
| author_role |
author |
| author2 |
Cordeiro, Sandra Duarte, Joana N. Costa, Paulo J. Mendes, Paulo J. Garcia, Maria Helena Baptista, Pedro V. Fernandes, Alexandra R. Morais, Tânia S. |
| author2_role |
author author author author author author author author |
| dc.contributor.none.fl_str_mv |
DCV - Departamento de Ciências da Vida UCIBIO - Applied Molecular Biosciences Unit RUN |
| dc.contributor.author.fl_str_mv |
Franco Machado, João Cordeiro, Sandra Duarte, Joana N. Costa, Paulo J. Mendes, Paulo J. Garcia, Maria Helena Baptista, Pedro V. Fernandes, Alexandra R. Morais, Tânia S. |
| dc.subject.por.fl_str_mv |
Physical and Theoretical Chemistry Inorganic Chemistry SDG 3 - Good Health and Well-being |
| topic |
Physical and Theoretical Chemistry Inorganic Chemistry SDG 3 - Good Health and Well-being |
| description |
Publisher Copyright: © 2024 The Authors. Published by American Chemical Society. |
| publishDate |
2024 |
| dc.date.none.fl_str_mv |
2024-05-23T00:32:56Z 2024-04-01 2024-04-01T00:00:00Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/167690 |
| url |
http://hdl.handle.net/10362/167690 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
0020-1669 PURE: 91740979 https://doi.org/10.1021/acs.inorgchem.3c03696 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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22 application/pdf |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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mluisa.alvim@gmail.com |
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1817546016903135232 |