Production of electrospun fast-dissolving drug delivery systems with therapeutic eutectic systems encapsulated in gelatin
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/47013 |
Resumo: | Fast-dissolving delivery systems (FDDS) have received increasing attention in the last years. Oral drug delivery is still the preferred route for the administration of pharmaceutical ingredients. Nevertheless, some patients, e.g. children or elderly people, have difficulties in swallowing solid tablets. In this work, gelatin membranes were produced by electrospinning, containing an encapsulated therapeutic deep-eutectic solvent (THEDES) composed by choline chloride/mandelic acid, in a 1:2 molar ratio. A gelatin solution (30% w/ v) with 2% (v/v) of THEDES was used to produce electrospun fibers and the experimental parameters were optimized. Due to the high surface area of polymer fibers, this type of construct has wide applicability. With no cytotoxicity effect, and showing a fast-dissolving release profile in PBS, the gelatin fibers with encapsulated THEDES seem to have promising applications in the development of new drug delivery systems. |
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Production of electrospun fast-dissolving drug delivery systems with therapeutic eutectic systems encapsulated in gelatinAnti-bacterial studiesFast-dissolving drug delivery systemsGelatinMandelic acidTherapeutic deep-eutectic solventsScience & TechnologyFast-dissolving delivery systems (FDDS) have received increasing attention in the last years. Oral drug delivery is still the preferred route for the administration of pharmaceutical ingredients. Nevertheless, some patients, e.g. children or elderly people, have difficulties in swallowing solid tablets. In this work, gelatin membranes were produced by electrospinning, containing an encapsulated therapeutic deep-eutectic solvent (THEDES) composed by choline chloride/mandelic acid, in a 1:2 molar ratio. A gelatin solution (30% w/ v) with 2% (v/v) of THEDES was used to produce electrospun fibers and the experimental parameters were optimized. Due to the high surface area of polymer fibers, this type of construct has wide applicability. With no cytotoxicity effect, and showing a fast-dissolving release profile in PBS, the gelatin fibers with encapsulated THEDES seem to have promising applications in the development of new drug delivery systems.The research leading to these results has received funding from Fundação para a Ciência e a Tecnologia (FCT) through the projects ENIGMA - PTDC/EQU-EPR/ 121491/2010 and UID/CTM/50025/2013, LAQVREQUIMTE: UID/QUI/50006/2013, UCIBIO-REQUIMTE: UID/Multi/04378/2013 (co-financed by the ERDF under the PT2020 Partnership Agreement [POCI-01-0145-FEDER- 007728]) and by FEDER through the COMPETE 2020 Programme. Marta Martins is grateful for financial support from FCT through the grant BIM/PTDC/EQUEPR/121491/ 2010/ENIGMA. This research has also received funding from the European Union Seventh Framework Programme (FP7/ 2007-2013) under grant agreement number REGPOTCT2012-316331-POLARIS and from the project BNovel smart and biomimetic materials for innovative regenerative medicine approaches^ RL1 - ABMR - NORTE-01-0124- FEDER-000016) co-financed by North Portugal Regional Operational Programme (ON.2 – O Novo Norte), under the National Strategic Reference Framework (NSRF), through the European Regional Development Fund (ERDF).info:eu-repo/semantics/publishedVersionAmerican Association of Pharmaceutical ScientistsUniversidade do MinhoMano, FranciscaMartins, MartaNogueira, Isabel SáBarreiros, SusanaBorges, João PauloReis, R. L.Duarte, Ana Rita C.Paiva, Alexandre2017-022017-02-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/47013engMano F., Martins M., Sá-Nogueira I., Barreiros S., Borges J. P., Reis R. L., Duarte A. R. C., Paiva A. Production of Electrospun Fast-Dissolving Drug Delivery Systems with Therapeutic Eutectic Systems Encapsulated in Gelatin, AAPS PharmSciTech, doi:10.1208/s12249-016-0703-z, 20171530-993210.1208/s12249-016-0703-z28236268info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:51:02Zoai:repositorium.sdum.uminho.pt:1822/47013Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:49:49.705407Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Production of electrospun fast-dissolving drug delivery systems with therapeutic eutectic systems encapsulated in gelatin |
title |
Production of electrospun fast-dissolving drug delivery systems with therapeutic eutectic systems encapsulated in gelatin |
spellingShingle |
Production of electrospun fast-dissolving drug delivery systems with therapeutic eutectic systems encapsulated in gelatin Mano, Francisca Anti-bacterial studies Fast-dissolving drug delivery systems Gelatin Mandelic acid Therapeutic deep-eutectic solvents Science & Technology |
title_short |
Production of electrospun fast-dissolving drug delivery systems with therapeutic eutectic systems encapsulated in gelatin |
title_full |
Production of electrospun fast-dissolving drug delivery systems with therapeutic eutectic systems encapsulated in gelatin |
title_fullStr |
Production of electrospun fast-dissolving drug delivery systems with therapeutic eutectic systems encapsulated in gelatin |
title_full_unstemmed |
Production of electrospun fast-dissolving drug delivery systems with therapeutic eutectic systems encapsulated in gelatin |
title_sort |
Production of electrospun fast-dissolving drug delivery systems with therapeutic eutectic systems encapsulated in gelatin |
author |
Mano, Francisca |
author_facet |
Mano, Francisca Martins, Marta Nogueira, Isabel Sá Barreiros, Susana Borges, João Paulo Reis, R. L. Duarte, Ana Rita C. Paiva, Alexandre |
author_role |
author |
author2 |
Martins, Marta Nogueira, Isabel Sá Barreiros, Susana Borges, João Paulo Reis, R. L. Duarte, Ana Rita C. Paiva, Alexandre |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Mano, Francisca Martins, Marta Nogueira, Isabel Sá Barreiros, Susana Borges, João Paulo Reis, R. L. Duarte, Ana Rita C. Paiva, Alexandre |
dc.subject.por.fl_str_mv |
Anti-bacterial studies Fast-dissolving drug delivery systems Gelatin Mandelic acid Therapeutic deep-eutectic solvents Science & Technology |
topic |
Anti-bacterial studies Fast-dissolving drug delivery systems Gelatin Mandelic acid Therapeutic deep-eutectic solvents Science & Technology |
description |
Fast-dissolving delivery systems (FDDS) have received increasing attention in the last years. Oral drug delivery is still the preferred route for the administration of pharmaceutical ingredients. Nevertheless, some patients, e.g. children or elderly people, have difficulties in swallowing solid tablets. In this work, gelatin membranes were produced by electrospinning, containing an encapsulated therapeutic deep-eutectic solvent (THEDES) composed by choline chloride/mandelic acid, in a 1:2 molar ratio. A gelatin solution (30% w/ v) with 2% (v/v) of THEDES was used to produce electrospun fibers and the experimental parameters were optimized. Due to the high surface area of polymer fibers, this type of construct has wide applicability. With no cytotoxicity effect, and showing a fast-dissolving release profile in PBS, the gelatin fibers with encapsulated THEDES seem to have promising applications in the development of new drug delivery systems. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-02 2017-02-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/47013 |
url |
http://hdl.handle.net/1822/47013 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Mano F., Martins M., Sá-Nogueira I., Barreiros S., Borges J. P., Reis R. L., Duarte A. R. C., Paiva A. Production of Electrospun Fast-Dissolving Drug Delivery Systems with Therapeutic Eutectic Systems Encapsulated in Gelatin, AAPS PharmSciTech, doi:10.1208/s12249-016-0703-z, 2017 1530-9932 10.1208/s12249-016-0703-z 28236268 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
American Association of Pharmaceutical Scientists |
publisher.none.fl_str_mv |
American Association of Pharmaceutical Scientists |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799133080846336000 |