Acute and chronic effects of testosterone and 4-hydroxyandrostenedione to the crustacean Daphnia magna
Autor(a) principal: | |
---|---|
Data de Publicação: | 2008 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10316/5838 https://doi.org/10.1016/j.ecoenv.2008.02.020 |
Resumo: | Steroid compounds have been globally detected in surface waters. The ecological impacts of these biologically active chemicals are largely unknown. Toxicity of testosterone and 4-hydroxyandrostenedione was assessed for the freshwater cladoceran Daphnia magna. Acute toxicity tests showed that 6.20 mg L-1 of testosterone, the highest concentration tested, did not have effect on the daphnids, whereas 4-hydroxyandrostenedione had an EC50 of 4.26 mg L-1. Chronic toxicity tests were carried out using survival, body length, fecundity, and fertility as endpoints. Long-term testosterone exposure reduced D. magna fecundity and fertility at concentrations ranging from 0.31 to 2.48 mg L-1. The significant decrease in fecundity was associated with an increase in aborted eggs. Long-term 4-hydroxyandrostenedione exposure at 0.84 mg L-1 increased the mortality of the neonates. The chronic toxicity effects were observed at concentrations higher than the measured environmental concentrations of these compounds. Nevertheless, the reproductive impairment of the daphnids is likely to occur at environmental levels as an ultimate response to long-term exposure. |
id |
RCAP_e51f57333aa9689021709c1d626686b5 |
---|---|
oai_identifier_str |
oai:estudogeral.uc.pt:10316/5838 |
network_acronym_str |
RCAP |
network_name_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository_id_str |
7160 |
spelling |
Acute and chronic effects of testosterone and 4-hydroxyandrostenedione to the crustacean Daphnia magnaSteroid compoundsTestosterone4-HydroxyandrostenedioneDaphnia magnaAcute toxicityChronic toxicityEndocrine disruptionEgg developmentSteroid compounds have been globally detected in surface waters. The ecological impacts of these biologically active chemicals are largely unknown. Toxicity of testosterone and 4-hydroxyandrostenedione was assessed for the freshwater cladoceran Daphnia magna. Acute toxicity tests showed that 6.20 mg L-1 of testosterone, the highest concentration tested, did not have effect on the daphnids, whereas 4-hydroxyandrostenedione had an EC50 of 4.26 mg L-1. Chronic toxicity tests were carried out using survival, body length, fecundity, and fertility as endpoints. Long-term testosterone exposure reduced D. magna fecundity and fertility at concentrations ranging from 0.31 to 2.48 mg L-1. The significant decrease in fecundity was associated with an increase in aborted eggs. Long-term 4-hydroxyandrostenedione exposure at 0.84 mg L-1 increased the mortality of the neonates. The chronic toxicity effects were observed at concentrations higher than the measured environmental concentrations of these compounds. Nevertheless, the reproductive impairment of the daphnids is likely to occur at environmental levels as an ultimate response to long-term exposure.http://www.sciencedirect.com/science/article/B6WDM-4S9R87Y-4/1/8d89a68996ddbd1b507b238f8dc2c3792008-09-26info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleaplication/PDFhttp://hdl.handle.net/10316/5838http://hdl.handle.net/10316/5838https://doi.org/10.1016/j.ecoenv.2008.02.020engEcotoxicology and Environmental Safety. In Press, Corrected Proof:Barbosa, Isabel R.Nogueira, António J. A.Soares, Amadeu M. V. M.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-05-25T04:21:59Zoai:estudogeral.uc.pt:10316/5838Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:47:26.669908Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Acute and chronic effects of testosterone and 4-hydroxyandrostenedione to the crustacean Daphnia magna |
title |
Acute and chronic effects of testosterone and 4-hydroxyandrostenedione to the crustacean Daphnia magna |
spellingShingle |
Acute and chronic effects of testosterone and 4-hydroxyandrostenedione to the crustacean Daphnia magna Barbosa, Isabel R. Steroid compounds Testosterone 4-Hydroxyandrostenedione Daphnia magna Acute toxicity Chronic toxicity Endocrine disruption Egg development |
title_short |
Acute and chronic effects of testosterone and 4-hydroxyandrostenedione to the crustacean Daphnia magna |
title_full |
Acute and chronic effects of testosterone and 4-hydroxyandrostenedione to the crustacean Daphnia magna |
title_fullStr |
Acute and chronic effects of testosterone and 4-hydroxyandrostenedione to the crustacean Daphnia magna |
title_full_unstemmed |
Acute and chronic effects of testosterone and 4-hydroxyandrostenedione to the crustacean Daphnia magna |
title_sort |
Acute and chronic effects of testosterone and 4-hydroxyandrostenedione to the crustacean Daphnia magna |
author |
Barbosa, Isabel R. |
author_facet |
Barbosa, Isabel R. Nogueira, António J. A. Soares, Amadeu M. V. M. |
author_role |
author |
author2 |
Nogueira, António J. A. Soares, Amadeu M. V. M. |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Barbosa, Isabel R. Nogueira, António J. A. Soares, Amadeu M. V. M. |
dc.subject.por.fl_str_mv |
Steroid compounds Testosterone 4-Hydroxyandrostenedione Daphnia magna Acute toxicity Chronic toxicity Endocrine disruption Egg development |
topic |
Steroid compounds Testosterone 4-Hydroxyandrostenedione Daphnia magna Acute toxicity Chronic toxicity Endocrine disruption Egg development |
description |
Steroid compounds have been globally detected in surface waters. The ecological impacts of these biologically active chemicals are largely unknown. Toxicity of testosterone and 4-hydroxyandrostenedione was assessed for the freshwater cladoceran Daphnia magna. Acute toxicity tests showed that 6.20 mg L-1 of testosterone, the highest concentration tested, did not have effect on the daphnids, whereas 4-hydroxyandrostenedione had an EC50 of 4.26 mg L-1. Chronic toxicity tests were carried out using survival, body length, fecundity, and fertility as endpoints. Long-term testosterone exposure reduced D. magna fecundity and fertility at concentrations ranging from 0.31 to 2.48 mg L-1. The significant decrease in fecundity was associated with an increase in aborted eggs. Long-term 4-hydroxyandrostenedione exposure at 0.84 mg L-1 increased the mortality of the neonates. The chronic toxicity effects were observed at concentrations higher than the measured environmental concentrations of these compounds. Nevertheless, the reproductive impairment of the daphnids is likely to occur at environmental levels as an ultimate response to long-term exposure. |
publishDate |
2008 |
dc.date.none.fl_str_mv |
2008-09-26 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10316/5838 http://hdl.handle.net/10316/5838 https://doi.org/10.1016/j.ecoenv.2008.02.020 |
url |
http://hdl.handle.net/10316/5838 https://doi.org/10.1016/j.ecoenv.2008.02.020 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Ecotoxicology and Environmental Safety. In Press, Corrected Proof: |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
aplication/PDF |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
|
_version_ |
1799133752007327744 |