Extracellular matrix and angiogenic factors in hematological diseases

Detalhes bibliográficos
Autor(a) principal: Salvador, Daniela Filipa Nobre
Data de Publicação: 2011
Tipo de documento: Dissertação
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.1/3003
Resumo: Dissertação de mest., Ciências Biomédicas, Departamento de Ciências Biomédicas e Medicina, Univ. do Algarve, 2011
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spelling Extracellular matrix and angiogenic factors in hematological diseasesMedula ósseaMicroambienteAngiogéneseSíndromes mielodisplásicasLeucemia mielóide agudaFibronectinaVEGFMetaloproteases de matrizDissertação de mest., Ciências Biomédicas, Departamento de Ciências Biomédicas e Medicina, Univ. do Algarve, 2011Bone marrow (BM) malignancies are clonal disorders resulting from neoplastic transformation of hematopoietic stem/progenitor cells (HSPCs). Among them, acute myeloid leukemia (AML) is characterized by a rapid increase in immature blood cells numbers, due to apoptosis suppression; myelodysplastic syndromes (MDS) are characterized by peripheral cytopenia, related with increased apoptosis, and can develop to AML. Angiogenesis is an important event that mediates the progression from a chronic to a more acute and aggressive pathology, and its significance in hematological malignancies has just beginning to be explored. BM microenvironment, including soluble factors and extracellular matrix (ECM), in particular fibronectin (FN) that has been found increased in solid tumors, may be responsible for BM disease progression, but its precise role in this context has been poorly investigated. Thus, the aim of this thesis was to know if the BM microenvironment differs between MDS and AML and what role might such factor be playing in disease progression. Our results indicate that MDS BM has more soluble VEGF, a pro-angiogenic factor, and higher matrix metalloproteinases (MMPs) activity, which may be responsible for increased angiogenesis occurring in this disease. Notch pathway, known to be involved in solid tumors angiogenesis, does not regulate FN expression in MDS BM, which leads to new formed vessels instability. In AML, VEGF is kept majorly bounded to FN, and MMPs activity is lower than in MDS BM. In such conditions, VEGF bioavailability is more regulated, being angiogenesis less exuberant. In addition to this, Notch pathway regulates FN deposition around new vessels, contributing to the formation of a more functional and stable vasculature in AML. To our knowledge, nothing has been described about the regulation of VEGF bioavailability in BM diseases, as well as regarding the possible effect of Notch signaling in angiogenesis of hematological dysfunctions.Dias, Sérgio Jerónimo RodriguesCachaço, Ana SofiaSapientiaSalvador, Daniela Filipa Nobre2013-10-03T10:23:52Z20112011-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisapplication/pdfhttp://hdl.handle.net/10400.1/3003TID:202485668enginfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-24T10:14:01Zoai:sapientia.ualg.pt:10400.1/3003Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:56:40.776621Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Extracellular matrix and angiogenic factors in hematological diseases
title Extracellular matrix and angiogenic factors in hematological diseases
spellingShingle Extracellular matrix and angiogenic factors in hematological diseases
Salvador, Daniela Filipa Nobre
Medula óssea
Microambiente
Angiogénese
Síndromes mielodisplásicas
Leucemia mielóide aguda
Fibronectina
VEGF
Metaloproteases de matriz
title_short Extracellular matrix and angiogenic factors in hematological diseases
title_full Extracellular matrix and angiogenic factors in hematological diseases
title_fullStr Extracellular matrix and angiogenic factors in hematological diseases
title_full_unstemmed Extracellular matrix and angiogenic factors in hematological diseases
title_sort Extracellular matrix and angiogenic factors in hematological diseases
author Salvador, Daniela Filipa Nobre
author_facet Salvador, Daniela Filipa Nobre
author_role author
dc.contributor.none.fl_str_mv Dias, Sérgio Jerónimo Rodrigues
Cachaço, Ana Sofia
Sapientia
dc.contributor.author.fl_str_mv Salvador, Daniela Filipa Nobre
dc.subject.por.fl_str_mv Medula óssea
Microambiente
Angiogénese
Síndromes mielodisplásicas
Leucemia mielóide aguda
Fibronectina
VEGF
Metaloproteases de matriz
topic Medula óssea
Microambiente
Angiogénese
Síndromes mielodisplásicas
Leucemia mielóide aguda
Fibronectina
VEGF
Metaloproteases de matriz
description Dissertação de mest., Ciências Biomédicas, Departamento de Ciências Biomédicas e Medicina, Univ. do Algarve, 2011
publishDate 2011
dc.date.none.fl_str_mv 2011
2011-01-01T00:00:00Z
2013-10-03T10:23:52Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/masterThesis
format masterThesis
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.1/3003
TID:202485668
url http://hdl.handle.net/10400.1/3003
identifier_str_mv TID:202485668
dc.language.iso.fl_str_mv eng
language eng
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dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
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