Relations between Cardiac and Visual Phenotypes in Diabetes: A Multivariate Approach
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10316/108854 https://doi.org/10.1371/journal.pone.0153772 |
Resumo: | Cardiovascular disease and diabetes represent a major public health concern. The former is the most frequent cause of death and disability in patients with type 2 diabetes, where left ventricular dysfunction is highly prevalent. Moreover, diabetic retinopathy is becoming a dominant cause of visual impairment and blindness. The complex relation between cardiovascular disease and diabetic retinopathy as a function of ageing, obesity and hypertension remains to be clarified. Here, we investigated such relations in patients with diabetes type 2, in subjects with neither overt heart disease nor advanced proliferative diabetic retinopathy. We studied 47 patients and 50 controls, aged between 45 and 65 years, equally distributed according to gender. From the 36 measures regarding visual structure and function, and the 11 measures concerning left ventricle function, we performed data reduction to obtain eight new derived variables, seven of which related to the eye, adjusted for age, gender, body mass index and high blood pressure using both discriminant analysis (DA) and logistic regression (LR). We found moderate to strong correlation between left ventricle function and the eye constructs: minimum correlation was found for psychophysical motion thresholds (DA: 0.734; LR: 0.666), while the maximum correlation was achieved with structural volume density in the neural retina (DA: 0.786; LR: 0.788). Controlling the effect of pairwise correlated visual constructs, the parameters that were most correlated to left ventricle function were volume density in retina and thickness of the retinal nerve fiber layers (adjusted multiple R2 is 0.819 and 0.730 for DA and LR), with additional contribution of psychophysical loss in achromatic contrast discrimination. We conclude that visual structural and functional changes in type 2 diabetes are related to heart dysfunction, when the effects of clinical, demographic and associated risk factors are taken into account, revealing a genuine relation between cardiac and retinal diabetic phenotypes. |
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Relations between Cardiac and Visual Phenotypes in Diabetes: A Multivariate ApproachAgedBody Mass IndexCardiovascular DiseasesCase-Control StudiesDiabetes Mellitus, Type 2Diabetic RetinopathyFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedPhenotypePilot ProjectsProspective StudiesCardiovascular disease and diabetes represent a major public health concern. The former is the most frequent cause of death and disability in patients with type 2 diabetes, where left ventricular dysfunction is highly prevalent. Moreover, diabetic retinopathy is becoming a dominant cause of visual impairment and blindness. The complex relation between cardiovascular disease and diabetic retinopathy as a function of ageing, obesity and hypertension remains to be clarified. Here, we investigated such relations in patients with diabetes type 2, in subjects with neither overt heart disease nor advanced proliferative diabetic retinopathy. We studied 47 patients and 50 controls, aged between 45 and 65 years, equally distributed according to gender. From the 36 measures regarding visual structure and function, and the 11 measures concerning left ventricle function, we performed data reduction to obtain eight new derived variables, seven of which related to the eye, adjusted for age, gender, body mass index and high blood pressure using both discriminant analysis (DA) and logistic regression (LR). We found moderate to strong correlation between left ventricle function and the eye constructs: minimum correlation was found for psychophysical motion thresholds (DA: 0.734; LR: 0.666), while the maximum correlation was achieved with structural volume density in the neural retina (DA: 0.786; LR: 0.788). Controlling the effect of pairwise correlated visual constructs, the parameters that were most correlated to left ventricle function were volume density in retina and thickness of the retinal nerve fiber layers (adjusted multiple R2 is 0.819 and 0.730 for DA and LR), with additional contribution of psychophysical loss in achromatic contrast discrimination. We conclude that visual structural and functional changes in type 2 diabetes are related to heart dysfunction, when the effects of clinical, demographic and associated risk factors are taken into account, revealing a genuine relation between cardiac and retinal diabetic phenotypes.Public Library of Science2016info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/108854http://hdl.handle.net/10316/108854https://doi.org/10.1371/journal.pone.0153772eng1932-6203Oliveiros, BárbaraSanches, MafaldaQuendera, BrunoGraça, BrunoGuelho, DanielaGomes, LeonorCarrilho, FranciscoAlves, Filipe CaseiroCastelo-Branco, Miguelinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-09-21T09:13:34Zoai:estudogeral.uc.pt:10316/108854Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:25:05.814561Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Relations between Cardiac and Visual Phenotypes in Diabetes: A Multivariate Approach |
title |
Relations between Cardiac and Visual Phenotypes in Diabetes: A Multivariate Approach |
spellingShingle |
Relations between Cardiac and Visual Phenotypes in Diabetes: A Multivariate Approach Oliveiros, Bárbara Aged Body Mass Index Cardiovascular Diseases Case-Control Studies Diabetes Mellitus, Type 2 Diabetic Retinopathy Female Humans Magnetic Resonance Imaging Male Middle Aged Phenotype Pilot Projects Prospective Studies |
title_short |
Relations between Cardiac and Visual Phenotypes in Diabetes: A Multivariate Approach |
title_full |
Relations between Cardiac and Visual Phenotypes in Diabetes: A Multivariate Approach |
title_fullStr |
Relations between Cardiac and Visual Phenotypes in Diabetes: A Multivariate Approach |
title_full_unstemmed |
Relations between Cardiac and Visual Phenotypes in Diabetes: A Multivariate Approach |
title_sort |
Relations between Cardiac and Visual Phenotypes in Diabetes: A Multivariate Approach |
author |
Oliveiros, Bárbara |
author_facet |
Oliveiros, Bárbara Sanches, Mafalda Quendera, Bruno Graça, Bruno Guelho, Daniela Gomes, Leonor Carrilho, Francisco Alves, Filipe Caseiro Castelo-Branco, Miguel |
author_role |
author |
author2 |
Sanches, Mafalda Quendera, Bruno Graça, Bruno Guelho, Daniela Gomes, Leonor Carrilho, Francisco Alves, Filipe Caseiro Castelo-Branco, Miguel |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Oliveiros, Bárbara Sanches, Mafalda Quendera, Bruno Graça, Bruno Guelho, Daniela Gomes, Leonor Carrilho, Francisco Alves, Filipe Caseiro Castelo-Branco, Miguel |
dc.subject.por.fl_str_mv |
Aged Body Mass Index Cardiovascular Diseases Case-Control Studies Diabetes Mellitus, Type 2 Diabetic Retinopathy Female Humans Magnetic Resonance Imaging Male Middle Aged Phenotype Pilot Projects Prospective Studies |
topic |
Aged Body Mass Index Cardiovascular Diseases Case-Control Studies Diabetes Mellitus, Type 2 Diabetic Retinopathy Female Humans Magnetic Resonance Imaging Male Middle Aged Phenotype Pilot Projects Prospective Studies |
description |
Cardiovascular disease and diabetes represent a major public health concern. The former is the most frequent cause of death and disability in patients with type 2 diabetes, where left ventricular dysfunction is highly prevalent. Moreover, diabetic retinopathy is becoming a dominant cause of visual impairment and blindness. The complex relation between cardiovascular disease and diabetic retinopathy as a function of ageing, obesity and hypertension remains to be clarified. Here, we investigated such relations in patients with diabetes type 2, in subjects with neither overt heart disease nor advanced proliferative diabetic retinopathy. We studied 47 patients and 50 controls, aged between 45 and 65 years, equally distributed according to gender. From the 36 measures regarding visual structure and function, and the 11 measures concerning left ventricle function, we performed data reduction to obtain eight new derived variables, seven of which related to the eye, adjusted for age, gender, body mass index and high blood pressure using both discriminant analysis (DA) and logistic regression (LR). We found moderate to strong correlation between left ventricle function and the eye constructs: minimum correlation was found for psychophysical motion thresholds (DA: 0.734; LR: 0.666), while the maximum correlation was achieved with structural volume density in the neural retina (DA: 0.786; LR: 0.788). Controlling the effect of pairwise correlated visual constructs, the parameters that were most correlated to left ventricle function were volume density in retina and thickness of the retinal nerve fiber layers (adjusted multiple R2 is 0.819 and 0.730 for DA and LR), with additional contribution of psychophysical loss in achromatic contrast discrimination. We conclude that visual structural and functional changes in type 2 diabetes are related to heart dysfunction, when the effects of clinical, demographic and associated risk factors are taken into account, revealing a genuine relation between cardiac and retinal diabetic phenotypes. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10316/108854 http://hdl.handle.net/10316/108854 https://doi.org/10.1371/journal.pone.0153772 |
url |
http://hdl.handle.net/10316/108854 https://doi.org/10.1371/journal.pone.0153772 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
1932-6203 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Public Library of Science |
publisher.none.fl_str_mv |
Public Library of Science |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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