UniHI 7: an enhanced database for retrieval and interactive analysis of human molecular interaction networks
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.1/11370 |
Resumo: | Unified Human Interactome (UniHI) (http://www.unihi.org) is a database for retrieval, analysis and visualization of human molecular interaction networks. Its primary aim is to provide a comprehensive and easy-to-use platform for network-based investigations to a wide community of researchers in biology and medicine. Here, we describe a major update (version 7) of the database previously featured in NAR Database Issue. UniHI 7 currently includes almost 350 000 molecular interactions between genes, proteins and drugs, as well as numerous other types of data such as gene expression and functional annotation. Multiple options for interactive filtering and highlighting of proteins can be employed to obtain more reliable and specific network structures. Expression and other genomic data can be uploaded by the user to examine local network structures. Additional built-in tools enable ready identification of known drug targets, as well as of biological processes, phenotypes and pathways enriched with network proteins. A distinctive feature of UniHI 7 is its user-friendly interface designed to be utilized in an intuitive manner, enabling researchers less acquainted with network analysis to perform state-of-the-art network-based investigations. |
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UniHI 7: an enhanced database for retrieval and interactive analysis of human molecular interaction networksProtein interaction network2013 UpdateBiologyIntegrationWebVisualizationResourcesDiseaseServerGenesUnified Human Interactome (UniHI) (http://www.unihi.org) is a database for retrieval, analysis and visualization of human molecular interaction networks. Its primary aim is to provide a comprehensive and easy-to-use platform for network-based investigations to a wide community of researchers in biology and medicine. Here, we describe a major update (version 7) of the database previously featured in NAR Database Issue. UniHI 7 currently includes almost 350 000 molecular interactions between genes, proteins and drugs, as well as numerous other types of data such as gene expression and functional annotation. Multiple options for interactive filtering and highlighting of proteins can be employed to obtain more reliable and specific network structures. Expression and other genomic data can be uploaded by the user to examine local network structures. Additional built-in tools enable ready identification of known drug targets, as well as of biological processes, phenotypes and pathways enriched with network proteins. A distinctive feature of UniHI 7 is its user-friendly interface designed to be utilized in an intuitive manner, enabling researchers less acquainted with network analysis to perform state-of-the-art network-based investigations.Portuguese Fundacao para a Ciencia e a Tecnologia (FCT) [PTDC/BIA-GEN/116519/2010]; CHDI Foundation [A-2666]; FCT [SFRH/BPD/70718/2010, PTDC/BIA-BCM/117975/2010]; Portuguese Fundacao para a Ciencia e a Tecnologia [PTDC/BIA-GEN/116519/2010]Oxford University PressSapientiaKalathur, Ravi Kiran ReddyPinto, Jose PedroHernandez-Prieto, Miguel A.Machado, RuiAlmeida, DulceChaurasia, GautamFutschik, Matthias E.2018-12-07T14:53:08Z2014-012014-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.1/11370eng0305-104810.1093/nar/gkt1100info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-24T10:23:10Zoai:sapientia.ualg.pt:10400.1/11370Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:02:53.568727Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
UniHI 7: an enhanced database for retrieval and interactive analysis of human molecular interaction networks |
title |
UniHI 7: an enhanced database for retrieval and interactive analysis of human molecular interaction networks |
spellingShingle |
UniHI 7: an enhanced database for retrieval and interactive analysis of human molecular interaction networks Kalathur, Ravi Kiran Reddy Protein interaction network 2013 Update Biology Integration Web Visualization Resources Disease Server Genes |
title_short |
UniHI 7: an enhanced database for retrieval and interactive analysis of human molecular interaction networks |
title_full |
UniHI 7: an enhanced database for retrieval and interactive analysis of human molecular interaction networks |
title_fullStr |
UniHI 7: an enhanced database for retrieval and interactive analysis of human molecular interaction networks |
title_full_unstemmed |
UniHI 7: an enhanced database for retrieval and interactive analysis of human molecular interaction networks |
title_sort |
UniHI 7: an enhanced database for retrieval and interactive analysis of human molecular interaction networks |
author |
Kalathur, Ravi Kiran Reddy |
author_facet |
Kalathur, Ravi Kiran Reddy Pinto, Jose Pedro Hernandez-Prieto, Miguel A. Machado, Rui Almeida, Dulce Chaurasia, Gautam Futschik, Matthias E. |
author_role |
author |
author2 |
Pinto, Jose Pedro Hernandez-Prieto, Miguel A. Machado, Rui Almeida, Dulce Chaurasia, Gautam Futschik, Matthias E. |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Sapientia |
dc.contributor.author.fl_str_mv |
Kalathur, Ravi Kiran Reddy Pinto, Jose Pedro Hernandez-Prieto, Miguel A. Machado, Rui Almeida, Dulce Chaurasia, Gautam Futschik, Matthias E. |
dc.subject.por.fl_str_mv |
Protein interaction network 2013 Update Biology Integration Web Visualization Resources Disease Server Genes |
topic |
Protein interaction network 2013 Update Biology Integration Web Visualization Resources Disease Server Genes |
description |
Unified Human Interactome (UniHI) (http://www.unihi.org) is a database for retrieval, analysis and visualization of human molecular interaction networks. Its primary aim is to provide a comprehensive and easy-to-use platform for network-based investigations to a wide community of researchers in biology and medicine. Here, we describe a major update (version 7) of the database previously featured in NAR Database Issue. UniHI 7 currently includes almost 350 000 molecular interactions between genes, proteins and drugs, as well as numerous other types of data such as gene expression and functional annotation. Multiple options for interactive filtering and highlighting of proteins can be employed to obtain more reliable and specific network structures. Expression and other genomic data can be uploaded by the user to examine local network structures. Additional built-in tools enable ready identification of known drug targets, as well as of biological processes, phenotypes and pathways enriched with network proteins. A distinctive feature of UniHI 7 is its user-friendly interface designed to be utilized in an intuitive manner, enabling researchers less acquainted with network analysis to perform state-of-the-art network-based investigations. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-01 2014-01-01T00:00:00Z 2018-12-07T14:53:08Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.1/11370 |
url |
http://hdl.handle.net/10400.1/11370 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
0305-1048 10.1093/nar/gkt1100 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Oxford University Press |
publisher.none.fl_str_mv |
Oxford University Press |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799133263391883264 |