Primary biliary cholangitis first demonstrated in pregnancy: a case report
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10316/103341 https://doi.org/10.1186/s13256-022-03260-7 |
Resumo: | Background: We present a case of primary biliary cholangitis diagnosed during pregnancy. Diagnosis of this entity in pregnancy is infrequent, and when everything seemed to point to a simple obstetric cholestasis, close attention to the details of the clinical history was required to raise suspicion of the true diagnosis. Case presentation: We present a 37-year-old Portuguese Caucasian patient who complained of generalized pruritus and showed alteration in hepatic function tests with a cholestatic pattern. The first diagnostic hypothesis was intrahepatic cholestasis of pregnancy, and she began treatment with ursodeoxycholic acid, which resulted in slight improvement of cholestasis. Her pregnancy was also complicated with occlusive hemorrhagic placenta, and at 30 weeks she underwent emergency cesarean section due to heavy blood loss. However, careful observation of clinical and laboratory findings, postpartum evolution, and a multidisciplinary approach to the patient led to the probable diagnosis of primary biliary cholangitis. Conclusions: Physiological changes during pregnancy can mimic chronic liver disease that can only be revealed at this stage, having an impact not only on the pregnancy but on the entire future of the woman. |
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Primary biliary cholangitis first demonstrated in pregnancy: a case reportPrimary biliary cholangitisPruritusPregnancyCase reportAdultCesarean SectionFemaleHumansPregnancyUrsodeoxycholic AcidCholestasisCholestasis, IntrahepaticLiver Cirrhosis, BiliaryBackground: We present a case of primary biliary cholangitis diagnosed during pregnancy. Diagnosis of this entity in pregnancy is infrequent, and when everything seemed to point to a simple obstetric cholestasis, close attention to the details of the clinical history was required to raise suspicion of the true diagnosis. Case presentation: We present a 37-year-old Portuguese Caucasian patient who complained of generalized pruritus and showed alteration in hepatic function tests with a cholestatic pattern. The first diagnostic hypothesis was intrahepatic cholestasis of pregnancy, and she began treatment with ursodeoxycholic acid, which resulted in slight improvement of cholestasis. Her pregnancy was also complicated with occlusive hemorrhagic placenta, and at 30 weeks she underwent emergency cesarean section due to heavy blood loss. However, careful observation of clinical and laboratory findings, postpartum evolution, and a multidisciplinary approach to the patient led to the probable diagnosis of primary biliary cholangitis. Conclusions: Physiological changes during pregnancy can mimic chronic liver disease that can only be revealed at this stage, having an impact not only on the pregnancy but on the entire future of the woman.2022-01-31info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/103341http://hdl.handle.net/10316/103341https://doi.org/10.1186/s13256-022-03260-7eng1752-1947Melo, DanielaAreia, Ana LuísaMoura, Pauloinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-11-08T21:33:40Zoai:estudogeral.uc.pt:10316/103341Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:20:11.783795Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Primary biliary cholangitis first demonstrated in pregnancy: a case report |
title |
Primary biliary cholangitis first demonstrated in pregnancy: a case report |
spellingShingle |
Primary biliary cholangitis first demonstrated in pregnancy: a case report Melo, Daniela Primary biliary cholangitis Pruritus Pregnancy Case report Adult Cesarean Section Female Humans Pregnancy Ursodeoxycholic Acid Cholestasis Cholestasis, Intrahepatic Liver Cirrhosis, Biliary |
title_short |
Primary biliary cholangitis first demonstrated in pregnancy: a case report |
title_full |
Primary biliary cholangitis first demonstrated in pregnancy: a case report |
title_fullStr |
Primary biliary cholangitis first demonstrated in pregnancy: a case report |
title_full_unstemmed |
Primary biliary cholangitis first demonstrated in pregnancy: a case report |
title_sort |
Primary biliary cholangitis first demonstrated in pregnancy: a case report |
author |
Melo, Daniela |
author_facet |
Melo, Daniela Areia, Ana Luísa Moura, Paulo |
author_role |
author |
author2 |
Areia, Ana Luísa Moura, Paulo |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Melo, Daniela Areia, Ana Luísa Moura, Paulo |
dc.subject.por.fl_str_mv |
Primary biliary cholangitis Pruritus Pregnancy Case report Adult Cesarean Section Female Humans Pregnancy Ursodeoxycholic Acid Cholestasis Cholestasis, Intrahepatic Liver Cirrhosis, Biliary |
topic |
Primary biliary cholangitis Pruritus Pregnancy Case report Adult Cesarean Section Female Humans Pregnancy Ursodeoxycholic Acid Cholestasis Cholestasis, Intrahepatic Liver Cirrhosis, Biliary |
description |
Background: We present a case of primary biliary cholangitis diagnosed during pregnancy. Diagnosis of this entity in pregnancy is infrequent, and when everything seemed to point to a simple obstetric cholestasis, close attention to the details of the clinical history was required to raise suspicion of the true diagnosis. Case presentation: We present a 37-year-old Portuguese Caucasian patient who complained of generalized pruritus and showed alteration in hepatic function tests with a cholestatic pattern. The first diagnostic hypothesis was intrahepatic cholestasis of pregnancy, and she began treatment with ursodeoxycholic acid, which resulted in slight improvement of cholestasis. Her pregnancy was also complicated with occlusive hemorrhagic placenta, and at 30 weeks she underwent emergency cesarean section due to heavy blood loss. However, careful observation of clinical and laboratory findings, postpartum evolution, and a multidisciplinary approach to the patient led to the probable diagnosis of primary biliary cholangitis. Conclusions: Physiological changes during pregnancy can mimic chronic liver disease that can only be revealed at this stage, having an impact not only on the pregnancy but on the entire future of the woman. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-01-31 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10316/103341 http://hdl.handle.net/10316/103341 https://doi.org/10.1186/s13256-022-03260-7 |
url |
http://hdl.handle.net/10316/103341 https://doi.org/10.1186/s13256-022-03260-7 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
1752-1947 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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