Development of UV cross-linked gelatin coated electrospun poly(caprolactone) fibrous scaffolds for tissue engineering

Detalhes bibliográficos
Autor(a) principal: Correia, Tiago R.
Data de Publicação: 2016
Outros Autores: Ferreira, Paula, Vaz, Rita, Alves, Patrícia, Figueiredo, Margarida, Correia, Ilídio Joaquim Sobreira, Coimbra, Patrícia
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.6/4684
Resumo: Cardiovascular disease is the leading cause of morbidity and mortality among industrialized countries. Vascular grafts are often required for the surgical treatments. Considering the limitations associated with the use of autografts and with the currently available synthetic materials, a growing demand in tissue engineered vascular grafts has been registered. During the work here described, electrospinning technique was used to prepared fibrous matrices to be applied as vascular implants. For that purpose, electrospun polycaprolactone (PCL) fibrous mats were produced and afterwards coated with different hydrogel formulations based in photocrosslinkable gelatin (GelMA) and the macromers poly(ethylene glycol) acrylate (PEGA) and poly(ethylene glycol) diacrylate (PEGDA). These were further photocrosslinked under UV irradiation using Irgacure® 2959 (by BASF) as the photoinitiator. The suitability of the coated scaffolds for the intended application, was evaluated by assessing their chemical/physical properties as well as their interaction with blood and endothelial cells.
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spelling Development of UV cross-linked gelatin coated electrospun poly(caprolactone) fibrous scaffolds for tissue engineeringPhotocrosslinkingScaffoldsGelatinBiocompatibilityElectrospinningCardiovascular disease is the leading cause of morbidity and mortality among industrialized countries. Vascular grafts are often required for the surgical treatments. Considering the limitations associated with the use of autografts and with the currently available synthetic materials, a growing demand in tissue engineered vascular grafts has been registered. During the work here described, electrospinning technique was used to prepared fibrous matrices to be applied as vascular implants. For that purpose, electrospun polycaprolactone (PCL) fibrous mats were produced and afterwards coated with different hydrogel formulations based in photocrosslinkable gelatin (GelMA) and the macromers poly(ethylene glycol) acrylate (PEGA) and poly(ethylene glycol) diacrylate (PEGDA). These were further photocrosslinked under UV irradiation using Irgacure® 2959 (by BASF) as the photoinitiator. The suitability of the coated scaffolds for the intended application, was evaluated by assessing their chemical/physical properties as well as their interaction with blood and endothelial cells.ElsevieruBibliorumCorreia, Tiago R.Ferreira, PaulaVaz, RitaAlves, PatríciaFigueiredo, MargaridaCorreia, Ilídio Joaquim SobreiraCoimbra, Patrícia2018-03-21T12:16:21Z2016-05-132016-05-13T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.6/4684engCorreia, T. R., Ferreira, P., Vaz, R., Alves, P., Figueiredo, M. M., Correia, I. J., e Coimbra, P. (2016) “Development of UV cross-linked gelatin coated electrospun poly (caprolactone) fibrous scaffolds for tissue engineering.” International Journal of Biological Macromolecules, Vol. 93 (Part B), pp. 1539-154810.1016/j.ijbiomac.2016.05.045metadata only accessinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-02-07T02:30:53Zoai:ubibliorum.ubi.pt:10400.6/4684Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T00:45:44.318503Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Development of UV cross-linked gelatin coated electrospun poly(caprolactone) fibrous scaffolds for tissue engineering
title Development of UV cross-linked gelatin coated electrospun poly(caprolactone) fibrous scaffolds for tissue engineering
spellingShingle Development of UV cross-linked gelatin coated electrospun poly(caprolactone) fibrous scaffolds for tissue engineering
Correia, Tiago R.
Photocrosslinking
Scaffolds
Gelatin
Biocompatibility
Electrospinning
title_short Development of UV cross-linked gelatin coated electrospun poly(caprolactone) fibrous scaffolds for tissue engineering
title_full Development of UV cross-linked gelatin coated electrospun poly(caprolactone) fibrous scaffolds for tissue engineering
title_fullStr Development of UV cross-linked gelatin coated electrospun poly(caprolactone) fibrous scaffolds for tissue engineering
title_full_unstemmed Development of UV cross-linked gelatin coated electrospun poly(caprolactone) fibrous scaffolds for tissue engineering
title_sort Development of UV cross-linked gelatin coated electrospun poly(caprolactone) fibrous scaffolds for tissue engineering
author Correia, Tiago R.
author_facet Correia, Tiago R.
Ferreira, Paula
Vaz, Rita
Alves, Patrícia
Figueiredo, Margarida
Correia, Ilídio Joaquim Sobreira
Coimbra, Patrícia
author_role author
author2 Ferreira, Paula
Vaz, Rita
Alves, Patrícia
Figueiredo, Margarida
Correia, Ilídio Joaquim Sobreira
Coimbra, Patrícia
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv uBibliorum
dc.contributor.author.fl_str_mv Correia, Tiago R.
Ferreira, Paula
Vaz, Rita
Alves, Patrícia
Figueiredo, Margarida
Correia, Ilídio Joaquim Sobreira
Coimbra, Patrícia
dc.subject.por.fl_str_mv Photocrosslinking
Scaffolds
Gelatin
Biocompatibility
Electrospinning
topic Photocrosslinking
Scaffolds
Gelatin
Biocompatibility
Electrospinning
description Cardiovascular disease is the leading cause of morbidity and mortality among industrialized countries. Vascular grafts are often required for the surgical treatments. Considering the limitations associated with the use of autografts and with the currently available synthetic materials, a growing demand in tissue engineered vascular grafts has been registered. During the work here described, electrospinning technique was used to prepared fibrous matrices to be applied as vascular implants. For that purpose, electrospun polycaprolactone (PCL) fibrous mats were produced and afterwards coated with different hydrogel formulations based in photocrosslinkable gelatin (GelMA) and the macromers poly(ethylene glycol) acrylate (PEGA) and poly(ethylene glycol) diacrylate (PEGDA). These were further photocrosslinked under UV irradiation using Irgacure® 2959 (by BASF) as the photoinitiator. The suitability of the coated scaffolds for the intended application, was evaluated by assessing their chemical/physical properties as well as their interaction with blood and endothelial cells.
publishDate 2016
dc.date.none.fl_str_mv 2016-05-13
2016-05-13T00:00:00Z
2018-03-21T12:16:21Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.6/4684
url http://hdl.handle.net/10400.6/4684
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Correia, T. R., Ferreira, P., Vaz, R., Alves, P., Figueiredo, M. M., Correia, I. J., e Coimbra, P. (2016) “Development of UV cross-linked gelatin coated electrospun poly (caprolactone) fibrous scaffolds for tissue engineering.” International Journal of Biological Macromolecules, Vol. 93 (Part B), pp. 1539-1548
10.1016/j.ijbiomac.2016.05.045
dc.rights.driver.fl_str_mv metadata only access
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dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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