Bioresorbable ureteral stents from natural origin polymers

Detalhes bibliográficos
Autor(a) principal: Barros, Alexandre A.
Data de Publicação: 2015
Outros Autores: Duarte, Antônio R. C., Pires, R. A., Lima, E., Mano, J. F., Reis, R. L., Ludovico, Paula, Sampaio-Marques, Belém
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://hdl.handle.net/1822/30255
Resumo: In this work, stents were produced from natural originpolysaccharides. Alginate, gellan gum, and a blend ofthese with gelatin were used to produce hollow tube (stents)following a combination of templated gelation and criticalpoint carbon dioxide drying. Morphological analysis of thesurface of the stents was carried out by scanning electronmicroscopy. Indwelling time, encrustation, and stability ofthe stents in artificial urine solution was carried out up to 60days of immersion. In vitro studies carried out with simulatedurine demonstrated that the tubes present a high fluid uptakeability, about 1000%. Despite this, the materials are able tomaintain their shape and do not present an extensive swellingbehavior. The bioresorption profile was observed to behighly dependent on the composition of the stent and it canbe tuned. Complete dissolution of the materials may occurbetween 14 and 60 days. Additionally, no encrustation wasobserved within the tested timeframe. The ability to resistbacterial adherence was evaluated with Gram-positive Staphylococcus aureus and two Gram-negatives Escherichia coliDH5 alpha and Klebsiella oxytoca. For K. oxytoca, no differenceswere observed in comparison with a commercialstent (BiosoftVR duo, Porges), although, for S. aureus alltested compositions had a higher inhibition of bacterialadhesion compared to the commercial stents. In case ofE. coli, the addition of gelatin to the formulations reducedthe bacterial adhesion in a highly significant manner comparedto the commercial stents. The stents produced by thedeveloped technology fulfill the requirements for ureteralstents and will contribute in the development of biocompatible and bioresorbable urinary stents.
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spelling Bioresorbable ureteral stents from natural origin polymersBioresorbableNatural origin polymersUreteral stentsaerogelhydrogelnatural polymersbioresorbable polymerskidney stonessupercritical fluid technologyaerogel/hydrogelScience & TechnologyIn this work, stents were produced from natural originpolysaccharides. Alginate, gellan gum, and a blend ofthese with gelatin were used to produce hollow tube (stents)following a combination of templated gelation and criticalpoint carbon dioxide drying. Morphological analysis of thesurface of the stents was carried out by scanning electronmicroscopy. Indwelling time, encrustation, and stability ofthe stents in artificial urine solution was carried out up to 60days of immersion. In vitro studies carried out with simulatedurine demonstrated that the tubes present a high fluid uptakeability, about 1000%. Despite this, the materials are able tomaintain their shape and do not present an extensive swellingbehavior. The bioresorption profile was observed to behighly dependent on the composition of the stent and it canbe tuned. Complete dissolution of the materials may occurbetween 14 and 60 days. Additionally, no encrustation wasobserved within the tested timeframe. The ability to resistbacterial adherence was evaluated with Gram-positive Staphylococcus aureus and two Gram-negatives Escherichia coliDH5 alpha and Klebsiella oxytoca. For K. oxytoca, no differenceswere observed in comparison with a commercialstent (BiosoftVR duo, Porges), although, for S. aureus alltested compositions had a higher inhibition of bacterialadhesion compared to the commercial stents. In case ofE. coli, the addition of gelatin to the formulations reducedthe bacterial adhesion in a highly significant manner comparedto the commercial stents. The stents produced by thedeveloped technology fulfill the requirements for ureteralstents and will contribute in the development of biocompatible and bioresorbable urinary stents.Contract grant sponsor: the European Union Seventh Framework Programme (FP7/2007-2013); contract grant number: REGPOT-CT2012-316331POLARIS Contract grant sponsor: Novel smart and biomimetic materials for innovative regenerative medicine approaches”; contract grant number: RL1 – ABMR – NORTE-01-0124-FEDER-000016; North Portugal Regional Operational Programme (ON.2 – O Novo Norte), National Strategic Reference Framework (NSRF), European Regional Development Fund (ERDF) Contract grant sponsor: FCT post-doc; contract grant numbers: SFRH/BPD/39333/2007, SFRH/BPD/90533/201Wiley-BlackwellUniversidade do MinhoBarros, Alexandre A.Duarte, Antônio R. C.Pires, R. A.Lima, E.Mano, J. F.Reis, R. L.Ludovico, PaulaSampaio-Marques, Belém20152015-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/1822/30255engBarros, A. A., Rita, A., Duarte, A. R. C., Pires, R. A., Sampaio-Marques, B., Ludovico, P., . . . Reis, R. L. (2015). Bioresorbable ureteral stents from natural origin polymers. Journal of Biomedical Materials Research - Part B Applied Biomaterials, 103(3), 608-617. doi: 10.1002/jbm.b.332371552-497310.1002/jbm.b.3323724965000http://onlinelibrary.wiley.com/doi/10.1002/jbm.b.33237/pdfinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:52:29Zoai:repositorium.sdum.uminho.pt:1822/30255Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:51:37.700797Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Bioresorbable ureteral stents from natural origin polymers
title Bioresorbable ureteral stents from natural origin polymers
spellingShingle Bioresorbable ureteral stents from natural origin polymers
Barros, Alexandre A.
Bioresorbable
Natural origin polymers
Ureteral stents
aerogel
hydrogel
natural polymers
bioresorbable polymers
kidney stones
supercritical fluid technology
aerogel/hydrogel
Science & Technology
title_short Bioresorbable ureteral stents from natural origin polymers
title_full Bioresorbable ureteral stents from natural origin polymers
title_fullStr Bioresorbable ureteral stents from natural origin polymers
title_full_unstemmed Bioresorbable ureteral stents from natural origin polymers
title_sort Bioresorbable ureteral stents from natural origin polymers
author Barros, Alexandre A.
author_facet Barros, Alexandre A.
Duarte, Antônio R. C.
Pires, R. A.
Lima, E.
Mano, J. F.
Reis, R. L.
Ludovico, Paula
Sampaio-Marques, Belém
author_role author
author2 Duarte, Antônio R. C.
Pires, R. A.
Lima, E.
Mano, J. F.
Reis, R. L.
Ludovico, Paula
Sampaio-Marques, Belém
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Barros, Alexandre A.
Duarte, Antônio R. C.
Pires, R. A.
Lima, E.
Mano, J. F.
Reis, R. L.
Ludovico, Paula
Sampaio-Marques, Belém
dc.subject.por.fl_str_mv Bioresorbable
Natural origin polymers
Ureteral stents
aerogel
hydrogel
natural polymers
bioresorbable polymers
kidney stones
supercritical fluid technology
aerogel/hydrogel
Science & Technology
topic Bioresorbable
Natural origin polymers
Ureteral stents
aerogel
hydrogel
natural polymers
bioresorbable polymers
kidney stones
supercritical fluid technology
aerogel/hydrogel
Science & Technology
description In this work, stents were produced from natural originpolysaccharides. Alginate, gellan gum, and a blend ofthese with gelatin were used to produce hollow tube (stents)following a combination of templated gelation and criticalpoint carbon dioxide drying. Morphological analysis of thesurface of the stents was carried out by scanning electronmicroscopy. Indwelling time, encrustation, and stability ofthe stents in artificial urine solution was carried out up to 60days of immersion. In vitro studies carried out with simulatedurine demonstrated that the tubes present a high fluid uptakeability, about 1000%. Despite this, the materials are able tomaintain their shape and do not present an extensive swellingbehavior. The bioresorption profile was observed to behighly dependent on the composition of the stent and it canbe tuned. Complete dissolution of the materials may occurbetween 14 and 60 days. Additionally, no encrustation wasobserved within the tested timeframe. The ability to resistbacterial adherence was evaluated with Gram-positive Staphylococcus aureus and two Gram-negatives Escherichia coliDH5 alpha and Klebsiella oxytoca. For K. oxytoca, no differenceswere observed in comparison with a commercialstent (BiosoftVR duo, Porges), although, for S. aureus alltested compositions had a higher inhibition of bacterialadhesion compared to the commercial stents. In case ofE. coli, the addition of gelatin to the formulations reducedthe bacterial adhesion in a highly significant manner comparedto the commercial stents. The stents produced by thedeveloped technology fulfill the requirements for ureteralstents and will contribute in the development of biocompatible and bioresorbable urinary stents.
publishDate 2015
dc.date.none.fl_str_mv 2015
2015-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://hdl.handle.net/1822/30255
url https://hdl.handle.net/1822/30255
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Barros, A. A., Rita, A., Duarte, A. R. C., Pires, R. A., Sampaio-Marques, B., Ludovico, P., . . . Reis, R. L. (2015). Bioresorbable ureteral stents from natural origin polymers. Journal of Biomedical Materials Research - Part B Applied Biomaterials, 103(3), 608-617. doi: 10.1002/jbm.b.33237
1552-4973
10.1002/jbm.b.33237
24965000
http://onlinelibrary.wiley.com/doi/10.1002/jbm.b.33237/pdf
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wiley-Blackwell
publisher.none.fl_str_mv Wiley-Blackwell
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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