Bioresorbable ureteral stents from natural origin polymers
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://hdl.handle.net/1822/30255 |
Resumo: | In this work, stents were produced from natural originpolysaccharides. Alginate, gellan gum, and a blend ofthese with gelatin were used to produce hollow tube (stents)following a combination of templated gelation and criticalpoint carbon dioxide drying. Morphological analysis of thesurface of the stents was carried out by scanning electronmicroscopy. Indwelling time, encrustation, and stability ofthe stents in artificial urine solution was carried out up to 60days of immersion. In vitro studies carried out with simulatedurine demonstrated that the tubes present a high fluid uptakeability, about 1000%. Despite this, the materials are able tomaintain their shape and do not present an extensive swellingbehavior. The bioresorption profile was observed to behighly dependent on the composition of the stent and it canbe tuned. Complete dissolution of the materials may occurbetween 14 and 60 days. Additionally, no encrustation wasobserved within the tested timeframe. The ability to resistbacterial adherence was evaluated with Gram-positive Staphylococcus aureus and two Gram-negatives Escherichia coliDH5 alpha and Klebsiella oxytoca. For K. oxytoca, no differenceswere observed in comparison with a commercialstent (BiosoftVR duo, Porges), although, for S. aureus alltested compositions had a higher inhibition of bacterialadhesion compared to the commercial stents. In case ofE. coli, the addition of gelatin to the formulations reducedthe bacterial adhesion in a highly significant manner comparedto the commercial stents. The stents produced by thedeveloped technology fulfill the requirements for ureteralstents and will contribute in the development of biocompatible and bioresorbable urinary stents. |
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Bioresorbable ureteral stents from natural origin polymersBioresorbableNatural origin polymersUreteral stentsaerogelhydrogelnatural polymersbioresorbable polymerskidney stonessupercritical fluid technologyaerogel/hydrogelScience & TechnologyIn this work, stents were produced from natural originpolysaccharides. Alginate, gellan gum, and a blend ofthese with gelatin were used to produce hollow tube (stents)following a combination of templated gelation and criticalpoint carbon dioxide drying. Morphological analysis of thesurface of the stents was carried out by scanning electronmicroscopy. Indwelling time, encrustation, and stability ofthe stents in artificial urine solution was carried out up to 60days of immersion. In vitro studies carried out with simulatedurine demonstrated that the tubes present a high fluid uptakeability, about 1000%. Despite this, the materials are able tomaintain their shape and do not present an extensive swellingbehavior. The bioresorption profile was observed to behighly dependent on the composition of the stent and it canbe tuned. Complete dissolution of the materials may occurbetween 14 and 60 days. Additionally, no encrustation wasobserved within the tested timeframe. The ability to resistbacterial adherence was evaluated with Gram-positive Staphylococcus aureus and two Gram-negatives Escherichia coliDH5 alpha and Klebsiella oxytoca. For K. oxytoca, no differenceswere observed in comparison with a commercialstent (BiosoftVR duo, Porges), although, for S. aureus alltested compositions had a higher inhibition of bacterialadhesion compared to the commercial stents. In case ofE. coli, the addition of gelatin to the formulations reducedthe bacterial adhesion in a highly significant manner comparedto the commercial stents. The stents produced by thedeveloped technology fulfill the requirements for ureteralstents and will contribute in the development of biocompatible and bioresorbable urinary stents.Contract grant sponsor: the European Union Seventh Framework Programme (FP7/2007-2013); contract grant number: REGPOT-CT2012-316331POLARIS Contract grant sponsor: Novel smart and biomimetic materials for innovative regenerative medicine approaches”; contract grant number: RL1 – ABMR – NORTE-01-0124-FEDER-000016; North Portugal Regional Operational Programme (ON.2 – O Novo Norte), National Strategic Reference Framework (NSRF), European Regional Development Fund (ERDF) Contract grant sponsor: FCT post-doc; contract grant numbers: SFRH/BPD/39333/2007, SFRH/BPD/90533/201Wiley-BlackwellUniversidade do MinhoBarros, Alexandre A.Duarte, Antônio R. C.Pires, R. A.Lima, E.Mano, J. F.Reis, R. L.Ludovico, PaulaSampaio-Marques, Belém20152015-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/1822/30255engBarros, A. A., Rita, A., Duarte, A. R. C., Pires, R. A., Sampaio-Marques, B., Ludovico, P., . . . Reis, R. L. (2015). Bioresorbable ureteral stents from natural origin polymers. Journal of Biomedical Materials Research - Part B Applied Biomaterials, 103(3), 608-617. doi: 10.1002/jbm.b.332371552-497310.1002/jbm.b.3323724965000http://onlinelibrary.wiley.com/doi/10.1002/jbm.b.33237/pdfinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:52:29Zoai:repositorium.sdum.uminho.pt:1822/30255Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:51:37.700797Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Bioresorbable ureteral stents from natural origin polymers |
title |
Bioresorbable ureteral stents from natural origin polymers |
spellingShingle |
Bioresorbable ureteral stents from natural origin polymers Barros, Alexandre A. Bioresorbable Natural origin polymers Ureteral stents aerogel hydrogel natural polymers bioresorbable polymers kidney stones supercritical fluid technology aerogel/hydrogel Science & Technology |
title_short |
Bioresorbable ureteral stents from natural origin polymers |
title_full |
Bioresorbable ureteral stents from natural origin polymers |
title_fullStr |
Bioresorbable ureteral stents from natural origin polymers |
title_full_unstemmed |
Bioresorbable ureteral stents from natural origin polymers |
title_sort |
Bioresorbable ureteral stents from natural origin polymers |
author |
Barros, Alexandre A. |
author_facet |
Barros, Alexandre A. Duarte, Antônio R. C. Pires, R. A. Lima, E. Mano, J. F. Reis, R. L. Ludovico, Paula Sampaio-Marques, Belém |
author_role |
author |
author2 |
Duarte, Antônio R. C. Pires, R. A. Lima, E. Mano, J. F. Reis, R. L. Ludovico, Paula Sampaio-Marques, Belém |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Barros, Alexandre A. Duarte, Antônio R. C. Pires, R. A. Lima, E. Mano, J. F. Reis, R. L. Ludovico, Paula Sampaio-Marques, Belém |
dc.subject.por.fl_str_mv |
Bioresorbable Natural origin polymers Ureteral stents aerogel hydrogel natural polymers bioresorbable polymers kidney stones supercritical fluid technology aerogel/hydrogel Science & Technology |
topic |
Bioresorbable Natural origin polymers Ureteral stents aerogel hydrogel natural polymers bioresorbable polymers kidney stones supercritical fluid technology aerogel/hydrogel Science & Technology |
description |
In this work, stents were produced from natural originpolysaccharides. Alginate, gellan gum, and a blend ofthese with gelatin were used to produce hollow tube (stents)following a combination of templated gelation and criticalpoint carbon dioxide drying. Morphological analysis of thesurface of the stents was carried out by scanning electronmicroscopy. Indwelling time, encrustation, and stability ofthe stents in artificial urine solution was carried out up to 60days of immersion. In vitro studies carried out with simulatedurine demonstrated that the tubes present a high fluid uptakeability, about 1000%. Despite this, the materials are able tomaintain their shape and do not present an extensive swellingbehavior. The bioresorption profile was observed to behighly dependent on the composition of the stent and it canbe tuned. Complete dissolution of the materials may occurbetween 14 and 60 days. Additionally, no encrustation wasobserved within the tested timeframe. The ability to resistbacterial adherence was evaluated with Gram-positive Staphylococcus aureus and two Gram-negatives Escherichia coliDH5 alpha and Klebsiella oxytoca. For K. oxytoca, no differenceswere observed in comparison with a commercialstent (BiosoftVR duo, Porges), although, for S. aureus alltested compositions had a higher inhibition of bacterialadhesion compared to the commercial stents. In case ofE. coli, the addition of gelatin to the formulations reducedthe bacterial adhesion in a highly significant manner comparedto the commercial stents. The stents produced by thedeveloped technology fulfill the requirements for ureteralstents and will contribute in the development of biocompatible and bioresorbable urinary stents. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015 2015-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://hdl.handle.net/1822/30255 |
url |
https://hdl.handle.net/1822/30255 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Barros, A. A., Rita, A., Duarte, A. R. C., Pires, R. A., Sampaio-Marques, B., Ludovico, P., . . . Reis, R. L. (2015). Bioresorbable ureteral stents from natural origin polymers. Journal of Biomedical Materials Research - Part B Applied Biomaterials, 103(3), 608-617. doi: 10.1002/jbm.b.33237 1552-4973 10.1002/jbm.b.33237 24965000 http://onlinelibrary.wiley.com/doi/10.1002/jbm.b.33237/pdf |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Wiley-Blackwell |
publisher.none.fl_str_mv |
Wiley-Blackwell |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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