A Review of the Application of Resorcinarenes and SBA-15 in Drug Delivery

• Autor(a) principal: Galindres, Diana M.
• Data de Publicação: 2022
• Outros Autores: Cifuentes, Diego, Tinoco, Luz Elena, Murillo-Acevedo, Yesid, Rodrigo, M. Melia, Ribeiro, Ana C. F., Esteso, Miguel A.
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
• Texto Completo: http://hdl.handle.net/10316/100516; https://doi.org/10.3390/pr10040684
• topic: resorcin[4]arenes; SBA-15; macrocycles; pharmacology; drug delivery; mesoporous silica; adsorbents; host-guest complex

Due to the diseases that people face today, scientists dedicate a part of their research to the synthesis, characterization, and study of functional compounds for controlled drug delivery. On the one hand, resorcinarenes are macrocycles obtained by condensation reactions of resorcinol and aldehyde. They include an upper and a lower rim functioning with different groups that confer solubility to the macrocycle and favor interactions with other compounds, therefore the hydroxyl groups on the upper rim improve the formation of hydrogen bonds. Additionally, resorcinarenes feature a cavity studied for forming host-guest complexes. SBA-15, on the other hand, is a mesoporous silica characterized by ordered pores in its structure and a large surface area. As a result of its properties, it has been used for several purposes, including absorbents, drug delivery, catalysis, and environmental processes. This review shows the recent advances in synthesis methods, characterization, micelle formation, interaction with other compounds, and host-guest procedures, as well as techniques for evaluating toxicity, drug retention, and their preliminary uses in pharmacology for macrocycles, such as resorcin[4]arenes and SBA-15.