Disclosing the potential of eleganolone for Parkinson’s disease therapeutics: neuroprotective and anti-inflammatory activities

Detalhes bibliográficos
Autor(a) principal: Silva, Joana
Data de Publicação: 2021
Outros Autores: Alves, Celso, Pinteus, Susete, Susano, Patrícia, Simões, Marco, Guedes, Miguel, Martins, Alice, Rehfeldt, Stephanie, Gaspar, Helena, Goettert, Márcia Inês, Alfonso, Amparo, Pedrosa, Rui
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.8/5996
Resumo: FCT is also acknowledged for the grant attributed to Joana Silva (SFRH/BD/103255/2014). This work was supported by the Portuguese Foundation for Science and Technology (FCT) through the strategic project UID/04292/2020 grant to MARE—Marine and Environmental Sciences Centre and UIDP/ 04046/2020 and UIDB/04046/2020 granted to BioISI—BioSystems and Integrative Sciences Institute, through POINT4PAC project (Oncologia de Precisao: Terapias e Tecnologias Inovadoras (SAICTPAC/0019/ 2015-LISBOA- 01–0145-FEDER-016405)), through CROSS-ATLANTIC project (PTDC/BIA-OUT/29250/2017), co-financed by COMPETE (POCI-01–0145-FEDER-029250) and through Molecules for Health project (PTDC/ BIA-BQM/28355/2017). This work was also funded by the Integrated Programme of SR&TD Smart Valorization of Endogenous Marine Biological Resources Under a Changing Climate (Centro01–0145-FEDER-000018), co-funded by Centro 2020 Programme, Portugal 2020, European Union, through the European Regional Development Fund.
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spelling Disclosing the potential of eleganolone for Parkinson’s disease therapeutics: neuroprotective and anti-inflammatory activitiesApoptosisDiterpenesMarine natural productsNF-kB pathwayNeurodegenerative diseasesOxidative stressFCT is also acknowledged for the grant attributed to Joana Silva (SFRH/BD/103255/2014). This work was supported by the Portuguese Foundation for Science and Technology (FCT) through the strategic project UID/04292/2020 grant to MARE—Marine and Environmental Sciences Centre and UIDP/ 04046/2020 and UIDB/04046/2020 granted to BioISI—BioSystems and Integrative Sciences Institute, through POINT4PAC project (Oncologia de Precisao: Terapias e Tecnologias Inovadoras (SAICTPAC/0019/ 2015-LISBOA- 01–0145-FEDER-016405)), through CROSS-ATLANTIC project (PTDC/BIA-OUT/29250/2017), co-financed by COMPETE (POCI-01–0145-FEDER-029250) and through Molecules for Health project (PTDC/ BIA-BQM/28355/2017). This work was also funded by the Integrated Programme of SR&TD Smart Valorization of Endogenous Marine Biological Resources Under a Changing Climate (Centro01–0145-FEDER-000018), co-funded by Centro 2020 Programme, Portugal 2020, European Union, through the European Regional Development Fund.The treatment of Parkinson´s disease (PD) has benefited from significant advances resulting from the increasing research efforts focused on new therapeutics. However, the current treatments for PD are mostly symptomatic, alleviating disease symptoms without reversing or retarding disease progression. Thus, it is critical to find new molecules that can result in more effective treatments. Within this framework, this study aims to evaluate the neuroprotective and anti-inflammatory effects of three compounds (eleganolone, eleganonal and fucosterol) isolated from the brown seaweed Bifurcaria bifurcata. In vitro neuroprotective effects were evaluated on a PD cellular model induced by the neurotoxin 6-hydroxydopamine (6-OHDA) on SH-SY5Y human cells, while lipopolysaccharide (LPS) -stimulated RAW 264.7 macrophages were used to evaluate the anti-inflammatory potential. Additionally, the underlying mechanisms of action were also investigated. Compounds were isolated by preparative chromatographic methods and their structural elucidation attained by NMR spectroscopy. Among the tested compounds, eleganolone (0.1–1 μM; 24 h) reverted the neurotoxicity induced by 6-OHDA in about 20%. The neuroprotective effects were mediated by mitochondrial protection, reduction of oxidative stress, inflammation and apoptosis, and inhibition of NF-kB pathway. The results suggest that eleganolone may provide advantages in the treatment of neurodegenerative conditions and, therefore, should be considered for future preclinical studies.ElsevierIC-OnlineSilva, JoanaAlves, CelsoPinteus, SuseteSusano, PatríciaSimões, MarcoGuedes, MiguelMartins, AliceRehfeldt, StephanieGaspar, HelenaGoettert, Márcia InêsAlfonso, AmparoPedrosa, Rui2021-08-03T14:19:56Z20212021-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.8/5996engJoana Silva, Celso Alves, Susete Pinteus, Patrícia Susano, Marco Simões, Miguel Guedes, Alice Martins, Stephanie Rehfeldt, Helena Gaspar, Márcia Goettert, Amparo Alfonso, Rui Pedrosa, Disclosing the potential of eleganolone for Parkinson’s disease therapeutics: Neuroprotective and anti-inflammatory activities, Pharmacological Research, Volume 168, 2021, 105589, ISSN 1043-6618, https://doi.org/10.1016/j.phrs.2021.1055891043-661810.1016/j.phrs.2021.105589metadata only accessinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-01-17T15:52:10Zoai:iconline.ipleiria.pt:10400.8/5996Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T01:49:20.989092Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Disclosing the potential of eleganolone for Parkinson’s disease therapeutics: neuroprotective and anti-inflammatory activities
title Disclosing the potential of eleganolone for Parkinson’s disease therapeutics: neuroprotective and anti-inflammatory activities
spellingShingle Disclosing the potential of eleganolone for Parkinson’s disease therapeutics: neuroprotective and anti-inflammatory activities
Silva, Joana
Apoptosis
Diterpenes
Marine natural products
NF-kB pathway
Neurodegenerative diseases
Oxidative stress
title_short Disclosing the potential of eleganolone for Parkinson’s disease therapeutics: neuroprotective and anti-inflammatory activities
title_full Disclosing the potential of eleganolone for Parkinson’s disease therapeutics: neuroprotective and anti-inflammatory activities
title_fullStr Disclosing the potential of eleganolone for Parkinson’s disease therapeutics: neuroprotective and anti-inflammatory activities
title_full_unstemmed Disclosing the potential of eleganolone for Parkinson’s disease therapeutics: neuroprotective and anti-inflammatory activities
title_sort Disclosing the potential of eleganolone for Parkinson’s disease therapeutics: neuroprotective and anti-inflammatory activities
author Silva, Joana
author_facet Silva, Joana
Alves, Celso
Pinteus, Susete
Susano, Patrícia
Simões, Marco
Guedes, Miguel
Martins, Alice
Rehfeldt, Stephanie
Gaspar, Helena
Goettert, Márcia Inês
Alfonso, Amparo
Pedrosa, Rui
author_role author
author2 Alves, Celso
Pinteus, Susete
Susano, Patrícia
Simões, Marco
Guedes, Miguel
Martins, Alice
Rehfeldt, Stephanie
Gaspar, Helena
Goettert, Márcia Inês
Alfonso, Amparo
Pedrosa, Rui
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv IC-Online
dc.contributor.author.fl_str_mv Silva, Joana
Alves, Celso
Pinteus, Susete
Susano, Patrícia
Simões, Marco
Guedes, Miguel
Martins, Alice
Rehfeldt, Stephanie
Gaspar, Helena
Goettert, Márcia Inês
Alfonso, Amparo
Pedrosa, Rui
dc.subject.por.fl_str_mv Apoptosis
Diterpenes
Marine natural products
NF-kB pathway
Neurodegenerative diseases
Oxidative stress
topic Apoptosis
Diterpenes
Marine natural products
NF-kB pathway
Neurodegenerative diseases
Oxidative stress
description FCT is also acknowledged for the grant attributed to Joana Silva (SFRH/BD/103255/2014). This work was supported by the Portuguese Foundation for Science and Technology (FCT) through the strategic project UID/04292/2020 grant to MARE—Marine and Environmental Sciences Centre and UIDP/ 04046/2020 and UIDB/04046/2020 granted to BioISI—BioSystems and Integrative Sciences Institute, through POINT4PAC project (Oncologia de Precisao: Terapias e Tecnologias Inovadoras (SAICTPAC/0019/ 2015-LISBOA- 01–0145-FEDER-016405)), through CROSS-ATLANTIC project (PTDC/BIA-OUT/29250/2017), co-financed by COMPETE (POCI-01–0145-FEDER-029250) and through Molecules for Health project (PTDC/ BIA-BQM/28355/2017). This work was also funded by the Integrated Programme of SR&TD Smart Valorization of Endogenous Marine Biological Resources Under a Changing Climate (Centro01–0145-FEDER-000018), co-funded by Centro 2020 Programme, Portugal 2020, European Union, through the European Regional Development Fund.
publishDate 2021
dc.date.none.fl_str_mv 2021-08-03T14:19:56Z
2021
2021-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.8/5996
url http://hdl.handle.net/10400.8/5996
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Joana Silva, Celso Alves, Susete Pinteus, Patrícia Susano, Marco Simões, Miguel Guedes, Alice Martins, Stephanie Rehfeldt, Helena Gaspar, Márcia Goettert, Amparo Alfonso, Rui Pedrosa, Disclosing the potential of eleganolone for Parkinson’s disease therapeutics: Neuroprotective and anti-inflammatory activities, Pharmacological Research, Volume 168, 2021, 105589, ISSN 1043-6618, https://doi.org/10.1016/j.phrs.2021.105589
1043-6618
10.1016/j.phrs.2021.105589
dc.rights.driver.fl_str_mv metadata only access
info:eu-repo/semantics/openAccess
rights_invalid_str_mv metadata only access
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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