Diaphragmatic hernia repair porcine model to compare the performance of biodegradable membranes against Gore‑Tex®
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2024 |
| Outros Autores: | , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | https://hdl.handle.net/1822/87359 |
Resumo: | Published: 24 November 2023 |
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Diaphragmatic hernia repair porcine model to compare the performance of biodegradable membranes against Gore‑Tex®Congenital diaphragmatic hernia repairDecellularized human chorion membraneElectrospun fibrous meshGore-Tex®Thoracoscopic surgeryPublished: 24 November 2023Background Patch repair of congenital diaphragmatic hernia (CDH) using Gore-Tex® is associated with infection, adhesions, hernia recurrence, long-term musculoskeletal sequels and poor tissue regeneration. To overcome these limitations, the performance of two novel biodegradable membranes was tested to repair CDH in a growing pig model. Methods Twelve male pigs were randomly assigned to 3 diferent groups of 4 animals each, determined by the type of patch used during thoracoscopic diaphragmatic hernia repair (Gore-Tex®, polycaprolactone electrospun membrane-PCLem, and decellularized human chorion membrane-dHCM). After 7 weeks, all animals were euthanized, followed by necropsy for diaphragmatic evaluation and histological analysis. Results Thoracoscopic defect creation and diaphragmatic repair were performed without any technical difculty in all groups. However, hernia recurrence rate was 0% in Gore-Tex®, 50% in PCLem and 100% in dHCM groups. At euthanasia, Gore-Tex® patches appeared virtually unchanged and covered with a fbrotic capsule, while PCLem and dHCM patches were replaced by either foppy connective tissue or vascularized and foppy regenerated membranous tissue, respectively. Conclusion Gore-Tex® was associated with a higher survival rate and lower recurrence. Nevertheless, the proposed biodegradable membranes were associated with better tissue integration when compared with Gore-Tex®.Open access funding provided by FCT|FCCN (b-on). This work was supported by the Portuguese Foundation for Science and Technology (FCT) for the grant of LP (PD/BD/128103/2016 and FSE/ POCH/PD/169/2013), the IF grant of AM (IF/00376/2014) and the project Cells4_IDs of NM-N (PTDC/BTM-SAL/28882/2017). The authors would like to thank the contributions to this research from the project “TERM RES Hub – Scientifc Infrastructure for Tissue Engineering and Regenerative Medicine”, reference PINFRA/22190/2016 (Norte01-0145-FEDER-022190), funded by the Portuguese National Science Foundation (FCT) in cooperation with the Northern Portugal Regional Coordination and Development Commission (CCDR-N), for providing relevant lab facilities, state-of-the art equipment and highly qualifed human resources.Springer NatureUniversidade do MinhoScuglia, MariannaFrazão, Laura P.Miranda, Alice Augusta MacedoMartins, AlbinoBarbosa-Sequeira, JoanaCoimbra, DianaLongatto, AdhemarReis, R. L.Silva, Cristina Isabel NogueiraNeves, N. M.Correia-Pinto, Jorge20242024-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/1822/87359engScuglia M., Frazão L. P., Miranda A., Martins A., Barbosa-Sequeira J., Coimbra D., Longatto-Filho A., Reis R. L., Nogueira-Silva C., Neves N. M., Correia-Pinto J. Diaphragmatic hernia repair porcine model to compare the performance of biodegradable membranes against Gore-Tex, Pediatric Surgery International, Vol. 4, pp. 7, doi:https://doi.org/10.1007/s00383-023-05584-x, 20231437-98131437-981310.1007/s00383-023-05584-x379997787https://link.springer.com/article/10.1007/s00383-023-05584-xinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-02-24T01:23:01Zoai:repositorium.sdum.uminho.pt:1822/87359Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T00:40:30.942349Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Diaphragmatic hernia repair porcine model to compare the performance of biodegradable membranes against Gore‑Tex® |
| title |
Diaphragmatic hernia repair porcine model to compare the performance of biodegradable membranes against Gore‑Tex® |
| spellingShingle |
Diaphragmatic hernia repair porcine model to compare the performance of biodegradable membranes against Gore‑Tex® Scuglia, Marianna Congenital diaphragmatic hernia repair Decellularized human chorion membrane Electrospun fibrous mesh Gore-Tex® Thoracoscopic surgery |
| title_short |
Diaphragmatic hernia repair porcine model to compare the performance of biodegradable membranes against Gore‑Tex® |
| title_full |
Diaphragmatic hernia repair porcine model to compare the performance of biodegradable membranes against Gore‑Tex® |
| title_fullStr |
Diaphragmatic hernia repair porcine model to compare the performance of biodegradable membranes against Gore‑Tex® |
| title_full_unstemmed |
Diaphragmatic hernia repair porcine model to compare the performance of biodegradable membranes against Gore‑Tex® |
| title_sort |
Diaphragmatic hernia repair porcine model to compare the performance of biodegradable membranes against Gore‑Tex® |
| author |
Scuglia, Marianna |
| author_facet |
Scuglia, Marianna Frazão, Laura P. Miranda, Alice Augusta Macedo Martins, Albino Barbosa-Sequeira, Joana Coimbra, Diana Longatto, Adhemar Reis, R. L. Silva, Cristina Isabel Nogueira Neves, N. M. Correia-Pinto, Jorge |
| author_role |
author |
| author2 |
Frazão, Laura P. Miranda, Alice Augusta Macedo Martins, Albino Barbosa-Sequeira, Joana Coimbra, Diana Longatto, Adhemar Reis, R. L. Silva, Cristina Isabel Nogueira Neves, N. M. Correia-Pinto, Jorge |
| author2_role |
author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Universidade do Minho |
| dc.contributor.author.fl_str_mv |
Scuglia, Marianna Frazão, Laura P. Miranda, Alice Augusta Macedo Martins, Albino Barbosa-Sequeira, Joana Coimbra, Diana Longatto, Adhemar Reis, R. L. Silva, Cristina Isabel Nogueira Neves, N. M. Correia-Pinto, Jorge |
| dc.subject.por.fl_str_mv |
Congenital diaphragmatic hernia repair Decellularized human chorion membrane Electrospun fibrous mesh Gore-Tex® Thoracoscopic surgery |
| topic |
Congenital diaphragmatic hernia repair Decellularized human chorion membrane Electrospun fibrous mesh Gore-Tex® Thoracoscopic surgery |
| description |
Published: 24 November 2023 |
| publishDate |
2024 |
| dc.date.none.fl_str_mv |
2024 2024-01-01T00:00:00Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
| dc.identifier.uri.fl_str_mv |
https://hdl.handle.net/1822/87359 |
| url |
https://hdl.handle.net/1822/87359 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
Scuglia M., Frazão L. P., Miranda A., Martins A., Barbosa-Sequeira J., Coimbra D., Longatto-Filho A., Reis R. L., Nogueira-Silva C., Neves N. M., Correia-Pinto J. Diaphragmatic hernia repair porcine model to compare the performance of biodegradable membranes against Gore-Tex, Pediatric Surgery International, Vol. 4, pp. 7, doi:https://doi.org/10.1007/s00383-023-05584-x, 2023 1437-9813 1437-9813 10.1007/s00383-023-05584-x 37999778 7 https://link.springer.com/article/10.1007/s00383-023-05584-x |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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Springer Nature |
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Springer Nature |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799136309872164864 |