Fishroesomes as carriers with antioxidant and anti-inflammatory bioactivities

Detalhes bibliográficos
Autor(a) principal: Guedes, Marta
Data de Publicação: 2021
Outros Autores: Vieira, Sara Filipa Fontoura, Reis, R. L., Ferreira, Helena Susana Costa Machado, Neves, N. M.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/75108
Resumo: The great diversity of marine habitats and organisms renders them a high-value source to find/develop novel drugs and formulations. Therefore, herein, sardine (Sardina pilchardus) roe was used as a lipidic source to produce liposomes. This fish product presents high nutritional value, being its lipidic content associated with important health benefits. Consequently, it can be advantageously used to produce therapeutically active delivery devices. Roe lipids were extracted using the Matyash method. After lipid film hydration and extrusion, sardine roe-derived large unilamellar liposomes (LUVs), designated as fishroesomes, presented a size of â 330 nm and a significant negative surface charge (â - 27 mV). Radical scavenging assays demonstrated that fishroesomes efficiently neutralized peroxyl, hydroxyl and nitric oxide radicals. Moreover, fishroesomes significantly reduced the expression of pro-inflammatory cytokines and chemokines by LPS-stimulated macrophages at non-toxic concentrations for L929 and THP-1 cells. Consequently, the developed liposomes exhibit unique properties as bioactive drug carriers for inflammatory diseases treatment.
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spelling Fishroesomes as carriers with antioxidant and anti-inflammatory bioactivitiesAnti-inflammatory activityAntioxidant activityFishroesomesInflammatory diseasesSardine roeScience & TechnologyThe great diversity of marine habitats and organisms renders them a high-value source to find/develop novel drugs and formulations. Therefore, herein, sardine (Sardina pilchardus) roe was used as a lipidic source to produce liposomes. This fish product presents high nutritional value, being its lipidic content associated with important health benefits. Consequently, it can be advantageously used to produce therapeutically active delivery devices. Roe lipids were extracted using the Matyash method. After lipid film hydration and extrusion, sardine roe-derived large unilamellar liposomes (LUVs), designated as fishroesomes, presented a size of â 330 nm and a significant negative surface charge (â - 27 mV). Radical scavenging assays demonstrated that fishroesomes efficiently neutralized peroxyl, hydroxyl and nitric oxide radicals. Moreover, fishroesomes significantly reduced the expression of pro-inflammatory cytokines and chemokines by LPS-stimulated macrophages at non-toxic concentrations for L929 and THP-1 cells. Consequently, the developed liposomes exhibit unique properties as bioactive drug carriers for inflammatory diseases treatment.This work was supported by FCT/MCTES (Portuguese Foundation for Science and Technology / Ministry of Science, Technology and Higher Education) or FSE/POCH (European Social Fund through the Operational Program of Human Capital) (grant numbers PD/169/2013, PD/ BD/113795/2015, PD/BD/135246/2017, PTDC/BTM-SAL/28882/ 2017), and the NORTE 2020 Structured Project, co-funded by Norte2020 (NORTE-01-0145-FEDER-000021). Authors also thank the local fisherman for the donation of the samples.ElsevierUniversidade do MinhoGuedes, MartaVieira, Sara Filipa FontouraReis, R. L.Ferreira, Helena Susana Costa MachadoNeves, N. M.2021-042021-04-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/75108engGuedes M., Vieira S. F., Reis R. L., Ferreira H., Neves N. M. Fishroesomes as carriers with antioxidant and anti-inflammatory bioactivities, Biomedicine & Pharmacotherapy, Vol. 140, pp. 111680, doi:10.1016/j.biopha.2021.111680, 20210753-332210.1016/j.biopha.2021.11168034020247https://pubmed.ncbi.nlm.nih.gov/34020247/info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:01:42Zoai:repositorium.sdum.uminho.pt:1822/75108Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:51:38.149984Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Fishroesomes as carriers with antioxidant and anti-inflammatory bioactivities
title Fishroesomes as carriers with antioxidant and anti-inflammatory bioactivities
spellingShingle Fishroesomes as carriers with antioxidant and anti-inflammatory bioactivities
Guedes, Marta
Anti-inflammatory activity
Antioxidant activity
Fishroesomes
Inflammatory diseases
Sardine roe
Science & Technology
title_short Fishroesomes as carriers with antioxidant and anti-inflammatory bioactivities
title_full Fishroesomes as carriers with antioxidant and anti-inflammatory bioactivities
title_fullStr Fishroesomes as carriers with antioxidant and anti-inflammatory bioactivities
title_full_unstemmed Fishroesomes as carriers with antioxidant and anti-inflammatory bioactivities
title_sort Fishroesomes as carriers with antioxidant and anti-inflammatory bioactivities
author Guedes, Marta
author_facet Guedes, Marta
Vieira, Sara Filipa Fontoura
Reis, R. L.
Ferreira, Helena Susana Costa Machado
Neves, N. M.
author_role author
author2 Vieira, Sara Filipa Fontoura
Reis, R. L.
Ferreira, Helena Susana Costa Machado
Neves, N. M.
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Guedes, Marta
Vieira, Sara Filipa Fontoura
Reis, R. L.
Ferreira, Helena Susana Costa Machado
Neves, N. M.
dc.subject.por.fl_str_mv Anti-inflammatory activity
Antioxidant activity
Fishroesomes
Inflammatory diseases
Sardine roe
Science & Technology
topic Anti-inflammatory activity
Antioxidant activity
Fishroesomes
Inflammatory diseases
Sardine roe
Science & Technology
description The great diversity of marine habitats and organisms renders them a high-value source to find/develop novel drugs and formulations. Therefore, herein, sardine (Sardina pilchardus) roe was used as a lipidic source to produce liposomes. This fish product presents high nutritional value, being its lipidic content associated with important health benefits. Consequently, it can be advantageously used to produce therapeutically active delivery devices. Roe lipids were extracted using the Matyash method. After lipid film hydration and extrusion, sardine roe-derived large unilamellar liposomes (LUVs), designated as fishroesomes, presented a size of â 330 nm and a significant negative surface charge (â - 27 mV). Radical scavenging assays demonstrated that fishroesomes efficiently neutralized peroxyl, hydroxyl and nitric oxide radicals. Moreover, fishroesomes significantly reduced the expression of pro-inflammatory cytokines and chemokines by LPS-stimulated macrophages at non-toxic concentrations for L929 and THP-1 cells. Consequently, the developed liposomes exhibit unique properties as bioactive drug carriers for inflammatory diseases treatment.
publishDate 2021
dc.date.none.fl_str_mv 2021-04
2021-04-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/75108
url http://hdl.handle.net/1822/75108
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Guedes M., Vieira S. F., Reis R. L., Ferreira H., Neves N. M. Fishroesomes as carriers with antioxidant and anti-inflammatory bioactivities, Biomedicine & Pharmacotherapy, Vol. 140, pp. 111680, doi:10.1016/j.biopha.2021.111680, 2021
0753-3322
10.1016/j.biopha.2021.111680
34020247
https://pubmed.ncbi.nlm.nih.gov/34020247/
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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