Oxaliplatin toxicity presenting as a liver nodule - case report

Detalhes bibliográficos
Autor(a) principal: Alexandrino, Henrique
Data de Publicação: 2015
Outros Autores: Oliveira, Domingos, Cipriano, Maria Augusta, Ferreira, Luís, Tralhão, J. Guilherme, Sousa, Francisco Castro
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10316/108965
https://doi.org/10.1186/s12885-015-1247-4
Resumo: Background: Oxaliplatin based chemotherapy is often used as adjuvant therapy in colon and rectal cancer. A reported side effect is Sinusoidal Obstruction Syndrome which is characterized by a spectrum of pathologic changes, from sinusoidal dilation, peri-sinusoidal haemorrhage, peliosis and nodular regenerative hyperplasia. Very rarely it can cause the development of liver nodules mimicking liver metastases. Herein, we report a case of Sinusoidal Obstruction Syndrome causing a liver nodule suspicious of liver metastasis on imaging. This is the third reported case of this complication of oxaliplatin toxicity, in which resection was performed and pathological diagnosis confirmed. Case presentation: We report the case of a 59 year old man with stage III colon cancer who underwent sigmoidectomy followed by adjuvant chemotherapy with oxaliplatin. One year after surgery a liver nodule was detected and the patient underwent right hepatectomy. Pathology showed no liver nodule and diagnosed sinusoidal obstruction syndrome. Conclusion: We describe the third reported case of a liver lesion mimicking a liver metastasis after oxaliplatin-based chemotherapy for colon cancer. We suggest that in patients heavily treated with oxaliplatin with de novo liver nodules, this differential diagnosis should be considered. In particular, in this population of patients an intense imagiologic evaluation and even a preoperative biopsy should be pursued to confirm the diagnosis of malignancy and avoid overtreatment.
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spelling Oxaliplatin toxicity presenting as a liver nodule - case reportAntineoplastic AgentsAntineoplastic Combined Chemotherapy ProtocolsBiopsyChemotherapy, AdjuvantColorectal NeoplasmsDiagnosis, DifferentialHepatic Veno-Occlusive DiseaseHumansLiverMaleMiddle AgedOrganoplatinum CompoundsOxaliplatinTomography, X-Ray ComputedBackground: Oxaliplatin based chemotherapy is often used as adjuvant therapy in colon and rectal cancer. A reported side effect is Sinusoidal Obstruction Syndrome which is characterized by a spectrum of pathologic changes, from sinusoidal dilation, peri-sinusoidal haemorrhage, peliosis and nodular regenerative hyperplasia. Very rarely it can cause the development of liver nodules mimicking liver metastases. Herein, we report a case of Sinusoidal Obstruction Syndrome causing a liver nodule suspicious of liver metastasis on imaging. This is the third reported case of this complication of oxaliplatin toxicity, in which resection was performed and pathological diagnosis confirmed. Case presentation: We report the case of a 59 year old man with stage III colon cancer who underwent sigmoidectomy followed by adjuvant chemotherapy with oxaliplatin. One year after surgery a liver nodule was detected and the patient underwent right hepatectomy. Pathology showed no liver nodule and diagnosed sinusoidal obstruction syndrome. Conclusion: We describe the third reported case of a liver lesion mimicking a liver metastasis after oxaliplatin-based chemotherapy for colon cancer. We suggest that in patients heavily treated with oxaliplatin with de novo liver nodules, this differential diagnosis should be considered. In particular, in this population of patients an intense imagiologic evaluation and even a preoperative biopsy should be pursued to confirm the diagnosis of malignancy and avoid overtreatment.Springer Nature2015-04-10info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/108965http://hdl.handle.net/10316/108965https://doi.org/10.1186/s12885-015-1247-4eng1471-2407Alexandrino, HenriqueOliveira, DomingosCipriano, Maria AugustaFerreira, LuísTralhão, J. GuilhermeSousa, Francisco Castroinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-09-26T11:23:29Zoai:estudogeral.uc.pt:10316/108965Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:25:11.821131Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Oxaliplatin toxicity presenting as a liver nodule - case report
title Oxaliplatin toxicity presenting as a liver nodule - case report
spellingShingle Oxaliplatin toxicity presenting as a liver nodule - case report
Alexandrino, Henrique
Antineoplastic Agents
Antineoplastic Combined Chemotherapy Protocols
Biopsy
Chemotherapy, Adjuvant
Colorectal Neoplasms
Diagnosis, Differential
Hepatic Veno-Occlusive Disease
Humans
Liver
Male
Middle Aged
Organoplatinum Compounds
Oxaliplatin
Tomography, X-Ray Computed
title_short Oxaliplatin toxicity presenting as a liver nodule - case report
title_full Oxaliplatin toxicity presenting as a liver nodule - case report
title_fullStr Oxaliplatin toxicity presenting as a liver nodule - case report
title_full_unstemmed Oxaliplatin toxicity presenting as a liver nodule - case report
title_sort Oxaliplatin toxicity presenting as a liver nodule - case report
author Alexandrino, Henrique
author_facet Alexandrino, Henrique
Oliveira, Domingos
Cipriano, Maria Augusta
Ferreira, Luís
Tralhão, J. Guilherme
Sousa, Francisco Castro
author_role author
author2 Oliveira, Domingos
Cipriano, Maria Augusta
Ferreira, Luís
Tralhão, J. Guilherme
Sousa, Francisco Castro
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Alexandrino, Henrique
Oliveira, Domingos
Cipriano, Maria Augusta
Ferreira, Luís
Tralhão, J. Guilherme
Sousa, Francisco Castro
dc.subject.por.fl_str_mv Antineoplastic Agents
Antineoplastic Combined Chemotherapy Protocols
Biopsy
Chemotherapy, Adjuvant
Colorectal Neoplasms
Diagnosis, Differential
Hepatic Veno-Occlusive Disease
Humans
Liver
Male
Middle Aged
Organoplatinum Compounds
Oxaliplatin
Tomography, X-Ray Computed
topic Antineoplastic Agents
Antineoplastic Combined Chemotherapy Protocols
Biopsy
Chemotherapy, Adjuvant
Colorectal Neoplasms
Diagnosis, Differential
Hepatic Veno-Occlusive Disease
Humans
Liver
Male
Middle Aged
Organoplatinum Compounds
Oxaliplatin
Tomography, X-Ray Computed
description Background: Oxaliplatin based chemotherapy is often used as adjuvant therapy in colon and rectal cancer. A reported side effect is Sinusoidal Obstruction Syndrome which is characterized by a spectrum of pathologic changes, from sinusoidal dilation, peri-sinusoidal haemorrhage, peliosis and nodular regenerative hyperplasia. Very rarely it can cause the development of liver nodules mimicking liver metastases. Herein, we report a case of Sinusoidal Obstruction Syndrome causing a liver nodule suspicious of liver metastasis on imaging. This is the third reported case of this complication of oxaliplatin toxicity, in which resection was performed and pathological diagnosis confirmed. Case presentation: We report the case of a 59 year old man with stage III colon cancer who underwent sigmoidectomy followed by adjuvant chemotherapy with oxaliplatin. One year after surgery a liver nodule was detected and the patient underwent right hepatectomy. Pathology showed no liver nodule and diagnosed sinusoidal obstruction syndrome. Conclusion: We describe the third reported case of a liver lesion mimicking a liver metastasis after oxaliplatin-based chemotherapy for colon cancer. We suggest that in patients heavily treated with oxaliplatin with de novo liver nodules, this differential diagnosis should be considered. In particular, in this population of patients an intense imagiologic evaluation and even a preoperative biopsy should be pursued to confirm the diagnosis of malignancy and avoid overtreatment.
publishDate 2015
dc.date.none.fl_str_mv 2015-04-10
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10316/108965
http://hdl.handle.net/10316/108965
https://doi.org/10.1186/s12885-015-1247-4
url http://hdl.handle.net/10316/108965
https://doi.org/10.1186/s12885-015-1247-4
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1471-2407
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Springer Nature
publisher.none.fl_str_mv Springer Nature
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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