Oxaliplatin toxicity presenting as a liver nodule - case report
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10316/108965 https://doi.org/10.1186/s12885-015-1247-4 |
Resumo: | Background: Oxaliplatin based chemotherapy is often used as adjuvant therapy in colon and rectal cancer. A reported side effect is Sinusoidal Obstruction Syndrome which is characterized by a spectrum of pathologic changes, from sinusoidal dilation, peri-sinusoidal haemorrhage, peliosis and nodular regenerative hyperplasia. Very rarely it can cause the development of liver nodules mimicking liver metastases. Herein, we report a case of Sinusoidal Obstruction Syndrome causing a liver nodule suspicious of liver metastasis on imaging. This is the third reported case of this complication of oxaliplatin toxicity, in which resection was performed and pathological diagnosis confirmed. Case presentation: We report the case of a 59 year old man with stage III colon cancer who underwent sigmoidectomy followed by adjuvant chemotherapy with oxaliplatin. One year after surgery a liver nodule was detected and the patient underwent right hepatectomy. Pathology showed no liver nodule and diagnosed sinusoidal obstruction syndrome. Conclusion: We describe the third reported case of a liver lesion mimicking a liver metastasis after oxaliplatin-based chemotherapy for colon cancer. We suggest that in patients heavily treated with oxaliplatin with de novo liver nodules, this differential diagnosis should be considered. In particular, in this population of patients an intense imagiologic evaluation and even a preoperative biopsy should be pursued to confirm the diagnosis of malignancy and avoid overtreatment. |
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Oxaliplatin toxicity presenting as a liver nodule - case reportAntineoplastic AgentsAntineoplastic Combined Chemotherapy ProtocolsBiopsyChemotherapy, AdjuvantColorectal NeoplasmsDiagnosis, DifferentialHepatic Veno-Occlusive DiseaseHumansLiverMaleMiddle AgedOrganoplatinum CompoundsOxaliplatinTomography, X-Ray ComputedBackground: Oxaliplatin based chemotherapy is often used as adjuvant therapy in colon and rectal cancer. A reported side effect is Sinusoidal Obstruction Syndrome which is characterized by a spectrum of pathologic changes, from sinusoidal dilation, peri-sinusoidal haemorrhage, peliosis and nodular regenerative hyperplasia. Very rarely it can cause the development of liver nodules mimicking liver metastases. Herein, we report a case of Sinusoidal Obstruction Syndrome causing a liver nodule suspicious of liver metastasis on imaging. This is the third reported case of this complication of oxaliplatin toxicity, in which resection was performed and pathological diagnosis confirmed. Case presentation: We report the case of a 59 year old man with stage III colon cancer who underwent sigmoidectomy followed by adjuvant chemotherapy with oxaliplatin. One year after surgery a liver nodule was detected and the patient underwent right hepatectomy. Pathology showed no liver nodule and diagnosed sinusoidal obstruction syndrome. Conclusion: We describe the third reported case of a liver lesion mimicking a liver metastasis after oxaliplatin-based chemotherapy for colon cancer. We suggest that in patients heavily treated with oxaliplatin with de novo liver nodules, this differential diagnosis should be considered. In particular, in this population of patients an intense imagiologic evaluation and even a preoperative biopsy should be pursued to confirm the diagnosis of malignancy and avoid overtreatment.Springer Nature2015-04-10info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/108965http://hdl.handle.net/10316/108965https://doi.org/10.1186/s12885-015-1247-4eng1471-2407Alexandrino, HenriqueOliveira, DomingosCipriano, Maria AugustaFerreira, LuísTralhão, J. GuilhermeSousa, Francisco Castroinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-09-26T11:23:29Zoai:estudogeral.uc.pt:10316/108965Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:25:11.821131Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Oxaliplatin toxicity presenting as a liver nodule - case report |
title |
Oxaliplatin toxicity presenting as a liver nodule - case report |
spellingShingle |
Oxaliplatin toxicity presenting as a liver nodule - case report Alexandrino, Henrique Antineoplastic Agents Antineoplastic Combined Chemotherapy Protocols Biopsy Chemotherapy, Adjuvant Colorectal Neoplasms Diagnosis, Differential Hepatic Veno-Occlusive Disease Humans Liver Male Middle Aged Organoplatinum Compounds Oxaliplatin Tomography, X-Ray Computed |
title_short |
Oxaliplatin toxicity presenting as a liver nodule - case report |
title_full |
Oxaliplatin toxicity presenting as a liver nodule - case report |
title_fullStr |
Oxaliplatin toxicity presenting as a liver nodule - case report |
title_full_unstemmed |
Oxaliplatin toxicity presenting as a liver nodule - case report |
title_sort |
Oxaliplatin toxicity presenting as a liver nodule - case report |
author |
Alexandrino, Henrique |
author_facet |
Alexandrino, Henrique Oliveira, Domingos Cipriano, Maria Augusta Ferreira, Luís Tralhão, J. Guilherme Sousa, Francisco Castro |
author_role |
author |
author2 |
Oliveira, Domingos Cipriano, Maria Augusta Ferreira, Luís Tralhão, J. Guilherme Sousa, Francisco Castro |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Alexandrino, Henrique Oliveira, Domingos Cipriano, Maria Augusta Ferreira, Luís Tralhão, J. Guilherme Sousa, Francisco Castro |
dc.subject.por.fl_str_mv |
Antineoplastic Agents Antineoplastic Combined Chemotherapy Protocols Biopsy Chemotherapy, Adjuvant Colorectal Neoplasms Diagnosis, Differential Hepatic Veno-Occlusive Disease Humans Liver Male Middle Aged Organoplatinum Compounds Oxaliplatin Tomography, X-Ray Computed |
topic |
Antineoplastic Agents Antineoplastic Combined Chemotherapy Protocols Biopsy Chemotherapy, Adjuvant Colorectal Neoplasms Diagnosis, Differential Hepatic Veno-Occlusive Disease Humans Liver Male Middle Aged Organoplatinum Compounds Oxaliplatin Tomography, X-Ray Computed |
description |
Background: Oxaliplatin based chemotherapy is often used as adjuvant therapy in colon and rectal cancer. A reported side effect is Sinusoidal Obstruction Syndrome which is characterized by a spectrum of pathologic changes, from sinusoidal dilation, peri-sinusoidal haemorrhage, peliosis and nodular regenerative hyperplasia. Very rarely it can cause the development of liver nodules mimicking liver metastases. Herein, we report a case of Sinusoidal Obstruction Syndrome causing a liver nodule suspicious of liver metastasis on imaging. This is the third reported case of this complication of oxaliplatin toxicity, in which resection was performed and pathological diagnosis confirmed. Case presentation: We report the case of a 59 year old man with stage III colon cancer who underwent sigmoidectomy followed by adjuvant chemotherapy with oxaliplatin. One year after surgery a liver nodule was detected and the patient underwent right hepatectomy. Pathology showed no liver nodule and diagnosed sinusoidal obstruction syndrome. Conclusion: We describe the third reported case of a liver lesion mimicking a liver metastasis after oxaliplatin-based chemotherapy for colon cancer. We suggest that in patients heavily treated with oxaliplatin with de novo liver nodules, this differential diagnosis should be considered. In particular, in this population of patients an intense imagiologic evaluation and even a preoperative biopsy should be pursued to confirm the diagnosis of malignancy and avoid overtreatment. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-04-10 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10316/108965 http://hdl.handle.net/10316/108965 https://doi.org/10.1186/s12885-015-1247-4 |
url |
http://hdl.handle.net/10316/108965 https://doi.org/10.1186/s12885-015-1247-4 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
1471-2407 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Springer Nature |
publisher.none.fl_str_mv |
Springer Nature |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799134135093035009 |