The antibacterial activity of polyoxometalates: structures, antibiotic effects and future perspectives

Detalhes bibliográficos
Autor(a) principal: Aureliano, M.
Data de Publicação: 2018
Outros Autores: Bijelic, Aleksandar, Rompel, Annette
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.1/10335
Resumo: Polyoxometalates (POMs) are, mostly anionic, metal oxide compounds that span a wide range of tunable physical and chemical features rendering them very interesting for biological purposes, an continuously emerging but little explored field. Due to their biological and biochemical effects, including antitumor, -viral and -bacterial properties, POMs and POM-based systems are considered as promising future metallodrugs. In this article, we focus on the antibacterial activity of POMs and their therapeutic potential in the battle against bacteria and their increasing resistance against pharmaceuticals. Recent advances in the synthesis of POMs are highlighted, with emphasis on the development and properties of biologically active POM-based hybrid and nanocomposite structures. By analysing the antibacterial activity and structure of POMs, putative mode of actions are provided, including potential targets for POM–protein interactions, and a structure–activity-relationship was established for a series of POMs against two bacteria, namely Helicobacter pylori and Streptococcus pneumoniae.
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spelling The antibacterial activity of polyoxometalates: structures, antibiotic effects and future perspectivesPolyoxometalatesAnti bacterialPolyoxometalates (POMs) are, mostly anionic, metal oxide compounds that span a wide range of tunable physical and chemical features rendering them very interesting for biological purposes, an continuously emerging but little explored field. Due to their biological and biochemical effects, including antitumor, -viral and -bacterial properties, POMs and POM-based systems are considered as promising future metallodrugs. In this article, we focus on the antibacterial activity of POMs and their therapeutic potential in the battle against bacteria and their increasing resistance against pharmaceuticals. Recent advances in the synthesis of POMs are highlighted, with emphasis on the development and properties of biologically active POM-based hybrid and nanocomposite structures. By analysing the antibacterial activity and structure of POMs, putative mode of actions are provided, including potential targets for POM–protein interactions, and a structure–activity-relationship was established for a series of POMs against two bacteria, namely Helicobacter pylori and Streptococcus pneumoniae.Royal Society of ChemistrySapientiaAureliano, M.Bijelic, AleksandarRompel, Annette2018-01-29T14:29:35Z20182018-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.1/10335eng1359-7345AUT: MAA01296;10.1039/c7cc07549ainfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-24T10:21:57Zoai:sapientia.ualg.pt:10400.1/10335Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:02:03.721842Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv The antibacterial activity of polyoxometalates: structures, antibiotic effects and future perspectives
title The antibacterial activity of polyoxometalates: structures, antibiotic effects and future perspectives
spellingShingle The antibacterial activity of polyoxometalates: structures, antibiotic effects and future perspectives
Aureliano, M.
Polyoxometalates
Anti bacterial
title_short The antibacterial activity of polyoxometalates: structures, antibiotic effects and future perspectives
title_full The antibacterial activity of polyoxometalates: structures, antibiotic effects and future perspectives
title_fullStr The antibacterial activity of polyoxometalates: structures, antibiotic effects and future perspectives
title_full_unstemmed The antibacterial activity of polyoxometalates: structures, antibiotic effects and future perspectives
title_sort The antibacterial activity of polyoxometalates: structures, antibiotic effects and future perspectives
author Aureliano, M.
author_facet Aureliano, M.
Bijelic, Aleksandar
Rompel, Annette
author_role author
author2 Bijelic, Aleksandar
Rompel, Annette
author2_role author
author
dc.contributor.none.fl_str_mv Sapientia
dc.contributor.author.fl_str_mv Aureliano, M.
Bijelic, Aleksandar
Rompel, Annette
dc.subject.por.fl_str_mv Polyoxometalates
Anti bacterial
topic Polyoxometalates
Anti bacterial
description Polyoxometalates (POMs) are, mostly anionic, metal oxide compounds that span a wide range of tunable physical and chemical features rendering them very interesting for biological purposes, an continuously emerging but little explored field. Due to their biological and biochemical effects, including antitumor, -viral and -bacterial properties, POMs and POM-based systems are considered as promising future metallodrugs. In this article, we focus on the antibacterial activity of POMs and their therapeutic potential in the battle against bacteria and their increasing resistance against pharmaceuticals. Recent advances in the synthesis of POMs are highlighted, with emphasis on the development and properties of biologically active POM-based hybrid and nanocomposite structures. By analysing the antibacterial activity and structure of POMs, putative mode of actions are provided, including potential targets for POM–protein interactions, and a structure–activity-relationship was established for a series of POMs against two bacteria, namely Helicobacter pylori and Streptococcus pneumoniae.
publishDate 2018
dc.date.none.fl_str_mv 2018-01-29T14:29:35Z
2018
2018-01-01T00:00:00Z
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AUT: MAA01296;
10.1039/c7cc07549a
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dc.publisher.none.fl_str_mv Royal Society of Chemistry
publisher.none.fl_str_mv Royal Society of Chemistry
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