Bone metastasis risk factors in breast cancer

Detalhes bibliográficos
Autor(a) principal: Pulido, Catarina
Data de Publicação: 2017
Outros Autores: Vendrell, Ines, Ferreira, Arlindo, Casimiro, Sandra, Mansinho, André, Alho, Irina, Costa, Luis
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/50997
Resumo: Copyright: © the authors; licensee ecancermedicalscience. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
id RCAP_e87df2287f2549ae616e8ab1050d36ca
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network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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spelling Bone metastasis risk factors in breast cancerBone metastasesBreast cancerRsk factorCopyright: © the authors; licensee ecancermedicalscience. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.Bone is the single most frequent site for bone metastasis in breast cancer patients. Patients with bone-only metastasis have a fairly good prognosis when compared with patients with visceral disease. Nevertheless, cancer-induced bone disease carries an important risk of developing skeletal related events that impact quality of life (QoL). It is therefore particularly important to stratify patients according to their risk of developing bone metastasis. In this context, several risk factors have been studied, including demographic, clinicopathological, genetic, and metabolic factors. Most of them show conflicting or non-definitive associations and are not validated for clinical use. Nonetheless, tumour intrinsic subtype is widely accepted as a major risk factor for bone metastasis development and luminal breast cancer carries an increased risk for bone disease. Other factors such as gene signatures, expression of specific cytokines (such as bone sialoprotein and bone morphogenetic protein 7) or components of the extracellular matrix (like bone crosslinked C-telopeptide) might also influence the development of bone metastasis. Knowledge of risk factors related with bone disease is of paramount importance as it might be a prediction tool for triggering the use of targeted agents and allow for better patient selection for future clinical trials.ecancerRepositório da Universidade de LisboaPulido, CatarinaVendrell, InesFerreira, ArlindoCasimiro, SandraMansinho, AndréAlho, IrinaCosta, Luis2022-01-26T15:00:04Z20172017-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/50997engEcancermedicalscience. 2017 Jan 24;11:71510.3332/ecancer.2017.7151754-6605info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-11-20T18:11:25Zoai:repositorio.ul.pt:10451/50997Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-11-20T18:11:25Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Bone metastasis risk factors in breast cancer
title Bone metastasis risk factors in breast cancer
spellingShingle Bone metastasis risk factors in breast cancer
Pulido, Catarina
Bone metastases
Breast cancer
Rsk factor
title_short Bone metastasis risk factors in breast cancer
title_full Bone metastasis risk factors in breast cancer
title_fullStr Bone metastasis risk factors in breast cancer
title_full_unstemmed Bone metastasis risk factors in breast cancer
title_sort Bone metastasis risk factors in breast cancer
author Pulido, Catarina
author_facet Pulido, Catarina
Vendrell, Ines
Ferreira, Arlindo
Casimiro, Sandra
Mansinho, André
Alho, Irina
Costa, Luis
author_role author
author2 Vendrell, Ines
Ferreira, Arlindo
Casimiro, Sandra
Mansinho, André
Alho, Irina
Costa, Luis
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Pulido, Catarina
Vendrell, Ines
Ferreira, Arlindo
Casimiro, Sandra
Mansinho, André
Alho, Irina
Costa, Luis
dc.subject.por.fl_str_mv Bone metastases
Breast cancer
Rsk factor
topic Bone metastases
Breast cancer
Rsk factor
description Copyright: © the authors; licensee ecancermedicalscience. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
publishDate 2017
dc.date.none.fl_str_mv 2017
2017-01-01T00:00:00Z
2022-01-26T15:00:04Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/50997
url http://hdl.handle.net/10451/50997
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Ecancermedicalscience. 2017 Jan 24;11:715
10.3332/ecancer.2017.715
1754-6605
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv ecancer
publisher.none.fl_str_mv ecancer
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv mluisa.alvim@gmail.com
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