Synthesis of functionalized fluorescent silver nanoparticles and their toxicological effect in aquatic environments (Goldfish) and HEPG2 cells

Detalhes bibliográficos
Autor(a) principal: Oliveira, E.
Data de Publicação: 2013
Outros Autores: Santos, H. M., Garcia-Pardo, Javier, Diniz, M., Lorenzo, Julia, Rodríguez-González, B., Capelo, J. L., Lodeiro, C.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/42017
Resumo: Authors thank Xunta de Galicia (Biomedicine) for the research grant 10CSA383009PR, and Scientific PROTEOMASS Association (Portugal) for financial support. Elisabete Oliveira and Hugo M. Santos thank to MEC-FCT (Portugal), for the post-doctoral grants SRFH/BPD/72557/2010 and SRFH/BPD/73997/2010. Julia Lorenzo thanks to Ministerio de Ciencia e Innovacion (MICINN) of Spain, for grant BIO2010-22321-C02. Authors thank the financial support by REQUIMTE-FCT PEst-C/EQB/LA0006/2013.
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spelling Synthesis of functionalized fluorescent silver nanoparticles and their toxicological effect in aquatic environments (Goldfish) and HEPG2 cellsCytotoxicityFluorescenceGoldfishHuman hepatoma cellsSilver nanoparticlesAuthors thank Xunta de Galicia (Biomedicine) for the research grant 10CSA383009PR, and Scientific PROTEOMASS Association (Portugal) for financial support. Elisabete Oliveira and Hugo M. Santos thank to MEC-FCT (Portugal), for the post-doctoral grants SRFH/BPD/72557/2010 and SRFH/BPD/73997/2010. Julia Lorenzo thanks to Ministerio de Ciencia e Innovacion (MICINN) of Spain, for grant BIO2010-22321-C02. Authors thank the financial support by REQUIMTE-FCT PEst-C/EQB/LA0006/2013.Silver nanoparticles, AgNPs, are widely used in our daily life, mostly due to their antibacterial, antiviral, and antifungal properties. However, their potential toxicity remains unclear. In order to unravel this issue, emissive AgNPs were first synthetized using an inexpensive photochemical method, and then their permeation was assessed in vivo in goldfish and in vitro in human hepatoma cells (HepG2). In addition, the oxidative stress caused by AgNPs was assessed in enzymes such as glutathione-S-transferase (GST), catalase (CAT), and in lipid peroxidation (LPO). This study demonstrates that the smallest sized AgNPs@3 promote the largest changes in gold fish livers, whereas AgNPs@1 were found to be toxic in HEPG2 cells depending on both the size and functionalized/stabilizer ligand. © 2013 Oliveira, Santos, Garcia-Pardo, Diniz, Lorenzo, Rodríguez-González, Capelo and Lodeiro.DQ - Departamento de QuímicaCQFB-REQUIMTE - Centro de Química Fina e Biotecnologia (Lab. Associado REQUIMTE)RUNOliveira, E.Santos, H. M.Garcia-Pardo, JavierDiniz, M.Lorenzo, JuliaRodríguez-González, B.Capelo, J. L.Lodeiro, C.2018-07-19T22:09:07Z2013-122013-12-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/42017eng2296-2646PURE: 2587433https://doi.org/10.3389/fchem.2013.00029info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T04:22:41Zoai:run.unl.pt:10362/42017Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:31:26.003868Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Synthesis of functionalized fluorescent silver nanoparticles and their toxicological effect in aquatic environments (Goldfish) and HEPG2 cells
title Synthesis of functionalized fluorescent silver nanoparticles and their toxicological effect in aquatic environments (Goldfish) and HEPG2 cells
spellingShingle Synthesis of functionalized fluorescent silver nanoparticles and their toxicological effect in aquatic environments (Goldfish) and HEPG2 cells
Oliveira, E.
Cytotoxicity
Fluorescence
Goldfish
Human hepatoma cells
Silver nanoparticles
title_short Synthesis of functionalized fluorescent silver nanoparticles and their toxicological effect in aquatic environments (Goldfish) and HEPG2 cells
title_full Synthesis of functionalized fluorescent silver nanoparticles and their toxicological effect in aquatic environments (Goldfish) and HEPG2 cells
title_fullStr Synthesis of functionalized fluorescent silver nanoparticles and their toxicological effect in aquatic environments (Goldfish) and HEPG2 cells
title_full_unstemmed Synthesis of functionalized fluorescent silver nanoparticles and their toxicological effect in aquatic environments (Goldfish) and HEPG2 cells
title_sort Synthesis of functionalized fluorescent silver nanoparticles and their toxicological effect in aquatic environments (Goldfish) and HEPG2 cells
author Oliveira, E.
author_facet Oliveira, E.
Santos, H. M.
Garcia-Pardo, Javier
Diniz, M.
Lorenzo, Julia
Rodríguez-González, B.
Capelo, J. L.
Lodeiro, C.
author_role author
author2 Santos, H. M.
Garcia-Pardo, Javier
Diniz, M.
Lorenzo, Julia
Rodríguez-González, B.
Capelo, J. L.
Lodeiro, C.
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv DQ - Departamento de Química
CQFB-REQUIMTE - Centro de Química Fina e Biotecnologia (Lab. Associado REQUIMTE)
RUN
dc.contributor.author.fl_str_mv Oliveira, E.
Santos, H. M.
Garcia-Pardo, Javier
Diniz, M.
Lorenzo, Julia
Rodríguez-González, B.
Capelo, J. L.
Lodeiro, C.
dc.subject.por.fl_str_mv Cytotoxicity
Fluorescence
Goldfish
Human hepatoma cells
Silver nanoparticles
topic Cytotoxicity
Fluorescence
Goldfish
Human hepatoma cells
Silver nanoparticles
description Authors thank Xunta de Galicia (Biomedicine) for the research grant 10CSA383009PR, and Scientific PROTEOMASS Association (Portugal) for financial support. Elisabete Oliveira and Hugo M. Santos thank to MEC-FCT (Portugal), for the post-doctoral grants SRFH/BPD/72557/2010 and SRFH/BPD/73997/2010. Julia Lorenzo thanks to Ministerio de Ciencia e Innovacion (MICINN) of Spain, for grant BIO2010-22321-C02. Authors thank the financial support by REQUIMTE-FCT PEst-C/EQB/LA0006/2013.
publishDate 2013
dc.date.none.fl_str_mv 2013-12
2013-12-01T00:00:00Z
2018-07-19T22:09:07Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/42017
url http://hdl.handle.net/10362/42017
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2296-2646
PURE: 2587433
https://doi.org/10.3389/fchem.2013.00029
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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