Solubility of Flurbiprofen in Supercritical Carbon Dioxide

Detalhes bibliográficos
Autor(a) principal: Duarte, Ana Rita C.
Data de Publicação: 2004
Outros Autores: Coimbra, Patrícia, Sousa, Hermínio C. de, Duarte, Catarina M. M.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10316/10384
https://doi.org/10.1021/je034099b
Resumo: Equilibrium solubility of flurbiprofen, a nonsteroidal antiinflammatory agent, in supercritical carbon dioxide was measured by a static analytical method in the pressure range from (8.0 to 25.0) MPa, at temperatures of (303.0, 313.0, and 323.0) K. The cosolvent effect of ethanol in the solubility of the bioactive compound in supercritical carbon dioxide was investigated at 18 MPa and 313 K. The results obtained have a potential application in supercritical processes for this drug. Experimental solubility data were correlated with an empirical density-based Chrastil model.
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spelling Solubility of Flurbiprofen in Supercritical Carbon DioxideEquilibrium solubility of flurbiprofen, a nonsteroidal antiinflammatory agent, in supercritical carbon dioxide was measured by a static analytical method in the pressure range from (8.0 to 25.0) MPa, at temperatures of (303.0, 313.0, and 323.0) K. The cosolvent effect of ethanol in the solubility of the bioactive compound in supercritical carbon dioxide was investigated at 18 MPa and 313 K. The results obtained have a potential application in supercritical processes for this drug. Experimental solubility data were correlated with an empirical density-based Chrastil model.American Chemical Society2004-05-13info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/10384http://hdl.handle.net/10316/10384https://doi.org/10.1021/je034099bengJournal of Chemical & Engineering Data. 49:3 (2004) 449-4520021-9568Duarte, Ana Rita C.Coimbra, PatríciaSousa, Hermínio C. deDuarte, Catarina M. M.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2020-05-29T09:42:36Zoai:estudogeral.uc.pt:10316/10384Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:59:14.836305Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Solubility of Flurbiprofen in Supercritical Carbon Dioxide
title Solubility of Flurbiprofen in Supercritical Carbon Dioxide
spellingShingle Solubility of Flurbiprofen in Supercritical Carbon Dioxide
Duarte, Ana Rita C.
title_short Solubility of Flurbiprofen in Supercritical Carbon Dioxide
title_full Solubility of Flurbiprofen in Supercritical Carbon Dioxide
title_fullStr Solubility of Flurbiprofen in Supercritical Carbon Dioxide
title_full_unstemmed Solubility of Flurbiprofen in Supercritical Carbon Dioxide
title_sort Solubility of Flurbiprofen in Supercritical Carbon Dioxide
author Duarte, Ana Rita C.
author_facet Duarte, Ana Rita C.
Coimbra, Patrícia
Sousa, Hermínio C. de
Duarte, Catarina M. M.
author_role author
author2 Coimbra, Patrícia
Sousa, Hermínio C. de
Duarte, Catarina M. M.
author2_role author
author
author
dc.contributor.author.fl_str_mv Duarte, Ana Rita C.
Coimbra, Patrícia
Sousa, Hermínio C. de
Duarte, Catarina M. M.
description Equilibrium solubility of flurbiprofen, a nonsteroidal antiinflammatory agent, in supercritical carbon dioxide was measured by a static analytical method in the pressure range from (8.0 to 25.0) MPa, at temperatures of (303.0, 313.0, and 323.0) K. The cosolvent effect of ethanol in the solubility of the bioactive compound in supercritical carbon dioxide was investigated at 18 MPa and 313 K. The results obtained have a potential application in supercritical processes for this drug. Experimental solubility data were correlated with an empirical density-based Chrastil model.
publishDate 2004
dc.date.none.fl_str_mv 2004-05-13
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10316/10384
http://hdl.handle.net/10316/10384
https://doi.org/10.1021/je034099b
url http://hdl.handle.net/10316/10384
https://doi.org/10.1021/je034099b
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Journal of Chemical & Engineering Data. 49:3 (2004) 449-452
0021-9568
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv American Chemical Society
publisher.none.fl_str_mv American Chemical Society
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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