Regulation of T cell responses by Heme Oxygenase-1

Detalhes bibliográficos
Autor(a) principal: Cortez, Eliane Cristina Monteiro
Data de Publicação: 2008
Tipo de documento: Dissertação
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/1327
Resumo: Tese de mestrado, Biologia (Biologia Molecular e Genética), 2008, Universidade de Lisboa, Faculdade de Ciências
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spelling Regulation of T cell responses by Heme Oxygenase-1Biologia molecularEsclerose múltiplaHeme oxigenase-1Teses de mestradoTese de mestrado, Biologia (Biologia Molecular e Genética), 2008, Universidade de Lisboa, Faculdade de CiênciasMultiple sclerosis (MS) is a chronic inflammatory disease that affects the central nervous system (CNS). It is estimated that over 2.5 million people, mainly young adults between 25 and 40 years old, suffer from this disease. MS pathology is characterized by multifocal CNS inflammation, degeneration of the myelin sheath, surrounding the axons of neurons, and formation of sclerotic plaques that leads to axonal damage. The etiology of the disease remains unknown with genetic and environmental factors being important for its development. Mechanisms that lead to CNS degeneration result from a local inflammatory response characterized by the recruitment of T cells that recognize myelin peptides against which they mount an effector response. Heme Oxygenase-1 (HO-1) is a ubiquitously expressed stress-induced enzyme, responsible for the degradation of free heme into iron (Fe), biliverdin (BV) and carbon monoxide (CO). HO-1 controls inflammatory processes such as the ones associated with the development of MS. It is expressed in the CNS during MS as well as in experimental autoimmune encephalomyelitis (EAE), a murine model of MS. Deletion of HO-1 is associated with increased susceptibility to EAE, while pharmacological induction of its expression arrests EAE progression. The protective effect of HO-1 is associated with inhibition of expression of histocompatibility complex class II (MHC class II) on antigen presenting cells (APC), including dendritic cells (DCs). The main hypothesis tested in this project was that expression of HO-1 in DCs might modulate T cell responses in a manner that prevents the progression of EAE. We found that absence of HO-1 in DCs does not affect significantly its maturation by modulating the expression of surface activation markers. However, we failed to demonstrate whether this absence could afford any effect on the disease, when DCs are adoptively transferred into naïve mice, leading to a more severe outcome when compared to Hmox1+/+ DCsResumo alargado em português disponível no documentoSoares, MiguelTelhada, Maria Margarida BlasquesRepositório da Universidade de LisboaCortez, Eliane Cristina Monteiro2010-07-27T08:57:33Z20082008-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisapplication/pdfapplication/pdftext/xmlhttp://hdl.handle.net/10451/1327enghttp://catalogo.ul.pt/F/?func=item-global&doc_library=ULB01&type=03&doc_number=000564316info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T15:40:48Zoai:repositorio.ul.pt:10451/1327Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:27:57.866919Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Regulation of T cell responses by Heme Oxygenase-1
title Regulation of T cell responses by Heme Oxygenase-1
spellingShingle Regulation of T cell responses by Heme Oxygenase-1
Cortez, Eliane Cristina Monteiro
Biologia molecular
Esclerose múltipla
Heme oxigenase-1
Teses de mestrado
title_short Regulation of T cell responses by Heme Oxygenase-1
title_full Regulation of T cell responses by Heme Oxygenase-1
title_fullStr Regulation of T cell responses by Heme Oxygenase-1
title_full_unstemmed Regulation of T cell responses by Heme Oxygenase-1
title_sort Regulation of T cell responses by Heme Oxygenase-1
author Cortez, Eliane Cristina Monteiro
author_facet Cortez, Eliane Cristina Monteiro
author_role author
dc.contributor.none.fl_str_mv Soares, Miguel
Telhada, Maria Margarida Blasques
Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Cortez, Eliane Cristina Monteiro
dc.subject.por.fl_str_mv Biologia molecular
Esclerose múltipla
Heme oxigenase-1
Teses de mestrado
topic Biologia molecular
Esclerose múltipla
Heme oxigenase-1
Teses de mestrado
description Tese de mestrado, Biologia (Biologia Molecular e Genética), 2008, Universidade de Lisboa, Faculdade de Ciências
publishDate 2008
dc.date.none.fl_str_mv 2008
2008-01-01T00:00:00Z
2010-07-27T08:57:33Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/masterThesis
format masterThesis
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/1327
url http://hdl.handle.net/10451/1327
dc.language.iso.fl_str_mv eng
language eng
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dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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