Vitamin E or coenzyme Q10 administration is not fully advantageous for heart mitochondrial function in diabetic goto kakizaki rats

• Autor(a) principal: Oliveira, Paulo J.
• Data de Publicação: 2004
• Outros Autores: Seiça, Raquel, Santos, Dario L., Rolo, Anabela P., Sardão, Vilma A., Ferreira, Fernanda M. L., Palmeira, Carlos M., Santos, Maria S., Moreno, António J. M.
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
• Texto Completo: http://hdl.handle.net/10316/5391; https://doi.org/10.1016/j.mito.2004.02.005
• topic: Goto-kakizaki rat; Vitamin E; Coenzyme Q; Diabetes; Mitochondria

The heart is one of the organs affected during the later stages of diabetes. Mitochondrial function has already been proposed to be affected during the course of diabetes. Nevertheless, little information is known concerning the impact of antioxidants in heart mitochondria of a milder model for diabetes, such as the Goto-Kakizaki (GK) rat, where mitochondrial function appears ameliorated. The objective of this work was to test if injections of Vitamin E and Coenzyme Q10, alone and in combination, were able to modify mitochondrial performance in the hearts of GK rats.