Evaluation of the in vitro and in vivo efficacy of ruthenium polypyridyl compounds against breast cancer
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2021 |
| Outros Autores: | , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10362/134694 |
Resumo: | Project ED431C 2018/39 PEst 20152020 UID/QUI/00100/2020 UIDP/04378/2020 UIDB/04378/2020 LA/P/0140/2020 |
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Evaluation of the in vitro and in vivo efficacy of ruthenium polypyridyl compounds against breast cancerCell cycleCell deathCytotoxicityIn vivo toxicityMCF7 zebrafish xenograftPolypyridyl compoundsRutheniumCatalysisMolecular BiologySpectroscopyComputer Science ApplicationsPhysical and Theoretical ChemistryOrganic ChemistryInorganic ChemistrySDG 3 - Good Health and Well-beingProject ED431C 2018/39 PEst 20152020 UID/QUI/00100/2020 UIDP/04378/2020 UIDB/04378/2020 LA/P/0140/2020The clinical success of cisplatin, carboplatin, and oxaliplatin has sparked the interest of medicinal inorganic chemistry to synthesize and study compounds with non‐platinum metal centers. Despite Ru(II)–polypyridyl complexes being widely studied and well established for their antitumor properties, there are not enough in vivo studies to establish the potentiality of this type of compound. Therefore, we report to the best of our knowledge the first in vivo study of Ru(II)– polypyridyl complexes against breast cancer with promising results. In order to conduct our study, we used MCF7 zebrafish xenografts and ruthenium complexes [Ru(bipy)2(C12H8N6‐N,N)][CF3SO3]2 Ru1 and [{Ru(bipy)2}2(μ‐C12H8N6‐N,N)][CF3SO3]4 Ru2, which were recently developed by our group. Ru1 and Ru2 reduced the tumor size by an average of 30% without causing significant signs of lethality when administered at low doses of 1.25 mg∙L−1. Moreover, the in vitro selectivity results were confirmed in vivo against MCF7 breast cancer cells. Surprisingly, this work suggests that both the mono‐ and the dinuclear Ru(II)–polypyridyl compounds have in vivo potential against breast cancer, since there were no significant differences between both treatments, highlighting Ru1 and Ru2 as promising chemotherapy agents in breast cancer therapy.Instituto de Tecnologia Química e Biológica António Xavier (ITQB)UCIBIO - Applied Molecular Biosciences UnitDCV - Departamento de Ciências da VidaRUNLenis‐Rojas, Oscar A.Roma‐Rodrigues, CatarinaFernandes, Alexandra R.Carvalho, AndreiaCordeiro, SandraGuerra‐Varela, JorgeSánchez, LauraVázquez‐García, DignaLópez‐Torres, MargaritaFernández, AlbertoFernández, Jesús J.2022-03-16T23:23:40Z2021-08-182021-08-18T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/134694eng1661-6596PURE: 42218018https://doi.org/10.3390/ijms22168916info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:13:09Zoai:run.unl.pt:10362/134694Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:48:12.369108Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Evaluation of the in vitro and in vivo efficacy of ruthenium polypyridyl compounds against breast cancer |
| title |
Evaluation of the in vitro and in vivo efficacy of ruthenium polypyridyl compounds against breast cancer |
| spellingShingle |
Evaluation of the in vitro and in vivo efficacy of ruthenium polypyridyl compounds against breast cancer Lenis‐Rojas, Oscar A. Cell cycle Cell death Cytotoxicity In vivo toxicity MCF7 zebrafish xenograft Polypyridyl compounds Ruthenium Catalysis Molecular Biology Spectroscopy Computer Science Applications Physical and Theoretical Chemistry Organic Chemistry Inorganic Chemistry SDG 3 - Good Health and Well-being |
| title_short |
Evaluation of the in vitro and in vivo efficacy of ruthenium polypyridyl compounds against breast cancer |
| title_full |
Evaluation of the in vitro and in vivo efficacy of ruthenium polypyridyl compounds against breast cancer |
| title_fullStr |
Evaluation of the in vitro and in vivo efficacy of ruthenium polypyridyl compounds against breast cancer |
| title_full_unstemmed |
Evaluation of the in vitro and in vivo efficacy of ruthenium polypyridyl compounds against breast cancer |
| title_sort |
Evaluation of the in vitro and in vivo efficacy of ruthenium polypyridyl compounds against breast cancer |
| author |
Lenis‐Rojas, Oscar A. |
| author_facet |
Lenis‐Rojas, Oscar A. Roma‐Rodrigues, Catarina Fernandes, Alexandra R. Carvalho, Andreia Cordeiro, Sandra Guerra‐Varela, Jorge Sánchez, Laura Vázquez‐García, Digna López‐Torres, Margarita Fernández, Alberto Fernández, Jesús J. |
| author_role |
author |
| author2 |
Roma‐Rodrigues, Catarina Fernandes, Alexandra R. Carvalho, Andreia Cordeiro, Sandra Guerra‐Varela, Jorge Sánchez, Laura Vázquez‐García, Digna López‐Torres, Margarita Fernández, Alberto Fernández, Jesús J. |
| author2_role |
author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Instituto de Tecnologia Química e Biológica António Xavier (ITQB) UCIBIO - Applied Molecular Biosciences Unit DCV - Departamento de Ciências da Vida RUN |
| dc.contributor.author.fl_str_mv |
Lenis‐Rojas, Oscar A. Roma‐Rodrigues, Catarina Fernandes, Alexandra R. Carvalho, Andreia Cordeiro, Sandra Guerra‐Varela, Jorge Sánchez, Laura Vázquez‐García, Digna López‐Torres, Margarita Fernández, Alberto Fernández, Jesús J. |
| dc.subject.por.fl_str_mv |
Cell cycle Cell death Cytotoxicity In vivo toxicity MCF7 zebrafish xenograft Polypyridyl compounds Ruthenium Catalysis Molecular Biology Spectroscopy Computer Science Applications Physical and Theoretical Chemistry Organic Chemistry Inorganic Chemistry SDG 3 - Good Health and Well-being |
| topic |
Cell cycle Cell death Cytotoxicity In vivo toxicity MCF7 zebrafish xenograft Polypyridyl compounds Ruthenium Catalysis Molecular Biology Spectroscopy Computer Science Applications Physical and Theoretical Chemistry Organic Chemistry Inorganic Chemistry SDG 3 - Good Health and Well-being |
| description |
Project ED431C 2018/39 PEst 20152020 UID/QUI/00100/2020 UIDP/04378/2020 UIDB/04378/2020 LA/P/0140/2020 |
| publishDate |
2021 |
| dc.date.none.fl_str_mv |
2021-08-18 2021-08-18T00:00:00Z 2022-03-16T23:23:40Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/134694 |
| url |
http://hdl.handle.net/10362/134694 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
1661-6596 PURE: 42218018 https://doi.org/10.3390/ijms22168916 |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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