The GO-DACT protocol : a multicentre, randomized, double-blind, parallel-group study to compare the efficacy of golimumab in combination with methotrexate (MTX) versus MTX monotherapy

Detalhes bibliográficos
Autor(a) principal: Vieira de Sousa, Elsa Cristina
Data de Publicação: 2018
Outros Autores: Canhao, Helena, Alves, Pedro, Rodrigues, Ana Maria, Teixeira, Filipa, Tavares-Costa, José, Bernardo, Alexandra, Pimenta, Sofia, Pimentel-Santos, Fernando, Gomes, João L, Aguiar, Renata, Videira, Taciana, Pinto, Patrícia, Catita, Cristina, Santos, Helena, Borges, Joana, Sequeira, Graça, Ribeiro, Célia, Teixeira, Lídia, Ávila-Ribeiro, Pedro, Martins, Fernando M, Ribeiro, Ruy M., Fonseca, João Eurico
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/45121
Resumo: © 2001-2020 Sociedade Portuguesa de Reumatologia
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spelling The GO-DACT protocol : a multicentre, randomized, double-blind, parallel-group study to compare the efficacy of golimumab in combination with methotrexate (MTX) versus MTX monotherapyClinical trialDactylitisTreatment algorithmPsoriatic arthritis© 2001-2020 Sociedade Portuguesa de ReumatologiaThe GO-DACT is an investigator-initiated, national, multicentric randomized placebo-controlled double-blinded trial, that assesses dactylitis as primary endpoint. Psoriatic arthritis patients naïve to methotrexate and biologic disease modifying anti-rheumatic drugs, with at least one active dactylitis, were assigned to golimumab in combination with methotrexate or placebo in combination with methotrexate, for 24 weeks. Both clinical (dactylitis severity score and the Leeds dactylitis index) and imaging (high resolution magnetic resonance imaging), among others, were assessed as outcomes. The main objective of GO-DACT is to provide evidence to improve the treatment algorithm and care of psoriatic arthritis patients with active dactylitis. In this manuscript we describe the GO-DACT protocol and general concepts of the methodology of this trial.Sociedade Portuguesa de ReumatologiaRepositório da Universidade de LisboaVieira de Sousa, Elsa CristinaCanhao, HelenaAlves, PedroRodrigues, Ana MariaTeixeira, FilipaTavares-Costa, JoséBernardo, AlexandraPimenta, SofiaPimentel-Santos, FernandoGomes, João LAguiar, RenataVideira, TacianaPinto, PatríciaCatita, CristinaSantos, HelenaBorges, JoanaSequeira, GraçaRibeiro, CéliaTeixeira, LídiaÁvila-Ribeiro, PedroMartins, Fernando MRibeiro, Ruy M.Fonseca, João Eurico2020-12-03T18:00:56Z20182018-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/45121engActa Reumatol Port. 2018 Apr-Jun; 43 (2): 80-920303-464Xinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:46:38Zoai:repositorio.ul.pt:10451/45121Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:57:36.113232Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv The GO-DACT protocol : a multicentre, randomized, double-blind, parallel-group study to compare the efficacy of golimumab in combination with methotrexate (MTX) versus MTX monotherapy
title The GO-DACT protocol : a multicentre, randomized, double-blind, parallel-group study to compare the efficacy of golimumab in combination with methotrexate (MTX) versus MTX monotherapy
spellingShingle The GO-DACT protocol : a multicentre, randomized, double-blind, parallel-group study to compare the efficacy of golimumab in combination with methotrexate (MTX) versus MTX monotherapy
Vieira de Sousa, Elsa Cristina
Clinical trial
Dactylitis
Treatment algorithm
Psoriatic arthritis
title_short The GO-DACT protocol : a multicentre, randomized, double-blind, parallel-group study to compare the efficacy of golimumab in combination with methotrexate (MTX) versus MTX monotherapy
title_full The GO-DACT protocol : a multicentre, randomized, double-blind, parallel-group study to compare the efficacy of golimumab in combination with methotrexate (MTX) versus MTX monotherapy
title_fullStr The GO-DACT protocol : a multicentre, randomized, double-blind, parallel-group study to compare the efficacy of golimumab in combination with methotrexate (MTX) versus MTX monotherapy
title_full_unstemmed The GO-DACT protocol : a multicentre, randomized, double-blind, parallel-group study to compare the efficacy of golimumab in combination with methotrexate (MTX) versus MTX monotherapy
title_sort The GO-DACT protocol : a multicentre, randomized, double-blind, parallel-group study to compare the efficacy of golimumab in combination with methotrexate (MTX) versus MTX monotherapy
author Vieira de Sousa, Elsa Cristina
author_facet Vieira de Sousa, Elsa Cristina
Canhao, Helena
Alves, Pedro
Rodrigues, Ana Maria
Teixeira, Filipa
Tavares-Costa, José
Bernardo, Alexandra
Pimenta, Sofia
Pimentel-Santos, Fernando
Gomes, João L
Aguiar, Renata
Videira, Taciana
Pinto, Patrícia
Catita, Cristina
Santos, Helena
Borges, Joana
Sequeira, Graça
Ribeiro, Célia
Teixeira, Lídia
Ávila-Ribeiro, Pedro
Martins, Fernando M
Ribeiro, Ruy M.
Fonseca, João Eurico
author_role author
author2 Canhao, Helena
Alves, Pedro
Rodrigues, Ana Maria
Teixeira, Filipa
Tavares-Costa, José
Bernardo, Alexandra
Pimenta, Sofia
Pimentel-Santos, Fernando
Gomes, João L
Aguiar, Renata
Videira, Taciana
Pinto, Patrícia
Catita, Cristina
Santos, Helena
Borges, Joana
Sequeira, Graça
Ribeiro, Célia
Teixeira, Lídia
Ávila-Ribeiro, Pedro
Martins, Fernando M
Ribeiro, Ruy M.
Fonseca, João Eurico
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Vieira de Sousa, Elsa Cristina
Canhao, Helena
Alves, Pedro
Rodrigues, Ana Maria
Teixeira, Filipa
Tavares-Costa, José
Bernardo, Alexandra
Pimenta, Sofia
Pimentel-Santos, Fernando
Gomes, João L
Aguiar, Renata
Videira, Taciana
Pinto, Patrícia
Catita, Cristina
Santos, Helena
Borges, Joana
Sequeira, Graça
Ribeiro, Célia
Teixeira, Lídia
Ávila-Ribeiro, Pedro
Martins, Fernando M
Ribeiro, Ruy M.
Fonseca, João Eurico
dc.subject.por.fl_str_mv Clinical trial
Dactylitis
Treatment algorithm
Psoriatic arthritis
topic Clinical trial
Dactylitis
Treatment algorithm
Psoriatic arthritis
description © 2001-2020 Sociedade Portuguesa de Reumatologia
publishDate 2018
dc.date.none.fl_str_mv 2018
2018-01-01T00:00:00Z
2020-12-03T18:00:56Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/45121
url http://hdl.handle.net/10451/45121
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Acta Reumatol Port. 2018 Apr-Jun; 43 (2): 80-92
0303-464X
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Sociedade Portuguesa de Reumatologia
publisher.none.fl_str_mv Sociedade Portuguesa de Reumatologia
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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