Challenges in risk assessment of multiple mycotoxins in food

Detalhes bibliográficos
Autor(a) principal: Assunção, Ricardo
Data de Publicação: 2016
Outros Autores: Silva, M.J., Alvito, Paula
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.18/4339
Resumo: Review article
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spelling Challenges in risk assessment of multiple mycotoxins in foodSegurança AlimentarToxicologiaAvaliação de RiscoSaúde HumanaMycotoxins MixturesHuman Risk AssessmentCombined ToxicityFood SafetyHuman HealthGenotoxicidade AmbientalReview articleMost fungi are able to produce several mycotoxins simultaneously and, consequently, to contaminate a wide variety of foodstuffs. Therefore, the risk of human co-exposure to multiple mycotoxins is real, raising a growing concern about their potential impact on human health. Besides, government and industry regulations are usually based on individual toxicities, and do not take into account the complex dynamics associated with interactions between co-occurring groups of mycotoxins. The present work assembles, for the first time, the challenges posed by the likelihood of human co-exposure to these toxins and the possibility of interactive effects occurring after absorption, towards knowledge generation to support a more accurate human risk assessment. Regarding hazard assessment, a physiologically-based framework is proposed in order to infer the health effects from exposure to multiple mycotoxins in food, including knowledge on the bioaccessibility, toxicokinetics and toxicodynamics of single and combined toxins. The prioritisation of the most relevant mixtures to be tested under experimental conditions that attempt to mimic human exposure and the use of adequate mathematical approaches to evaluate interactions, particularly concerning the combined genotoxicity, were identified as the main challenges for hazard assessment. Regarding exposure assessment, the need of harmonised food consumption data, availability of multianalyte methods for mycotoxin quantification, management of left-censored data, use of probabilistic models and multibiomarker approaches are highlighted, in order to develop a more precise and realistic exposure assessment. To conclude, further studies on hazard and exposure assessment of multiple mycotoxins, using harmonised methodologies, are crucial towards an improvement of data quality and a more reliable and robust risk characterisation, which is central for risk management and, consequently, to prevent mycotoxins-associated adverse effects. A deep understanding of the nature of interactions between multiple mycotoxins will contribute to draw real conclusions on the health impact of human exposure to mycotoxin mixtures.This research was performed under the MycoMix project ‘Exploring the toxic effects of mixtures of mycotoxins in infant food and potential health impact’ (PTDC/DTP-FTO/0417/2012), through CESAM: UID/AMB/50017/2013 and ToxOmics: UID/BIM/00009/2013, all funded by the Fundação para a Ciência e Tecnologia (FCT), Portugal.Wageningen Academic PublishersRepositório Científico do Instituto Nacional de SaúdeAssunção, RicardoSilva, M.J.Alvito, Paula2017-02-21T15:47:10Z2016-10-112016-10-11T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/4339engWorld Mycotoxin Journal. 2016;9(5):791-811. doi:10.3920/WMJ2016.2039. Epub 2016 Oct 111875-071010.3920/WMJ2016.2039info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-20T15:40:09Zoai:repositorio.insa.pt:10400.18/4339Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:38:55.615263Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Challenges in risk assessment of multiple mycotoxins in food
title Challenges in risk assessment of multiple mycotoxins in food
spellingShingle Challenges in risk assessment of multiple mycotoxins in food
Assunção, Ricardo
Segurança Alimentar
Toxicologia
Avaliação de Risco
Saúde Humana
Mycotoxins Mixtures
Human Risk Assessment
Combined Toxicity
Food Safety
Human Health
Genotoxicidade Ambiental
title_short Challenges in risk assessment of multiple mycotoxins in food
title_full Challenges in risk assessment of multiple mycotoxins in food
title_fullStr Challenges in risk assessment of multiple mycotoxins in food
title_full_unstemmed Challenges in risk assessment of multiple mycotoxins in food
title_sort Challenges in risk assessment of multiple mycotoxins in food
author Assunção, Ricardo
author_facet Assunção, Ricardo
Silva, M.J.
Alvito, Paula
author_role author
author2 Silva, M.J.
Alvito, Paula
author2_role author
author
dc.contributor.none.fl_str_mv Repositório Científico do Instituto Nacional de Saúde
dc.contributor.author.fl_str_mv Assunção, Ricardo
Silva, M.J.
Alvito, Paula
dc.subject.por.fl_str_mv Segurança Alimentar
Toxicologia
Avaliação de Risco
Saúde Humana
Mycotoxins Mixtures
Human Risk Assessment
Combined Toxicity
Food Safety
Human Health
Genotoxicidade Ambiental
topic Segurança Alimentar
Toxicologia
Avaliação de Risco
Saúde Humana
Mycotoxins Mixtures
Human Risk Assessment
Combined Toxicity
Food Safety
Human Health
Genotoxicidade Ambiental
description Review article
publishDate 2016
dc.date.none.fl_str_mv 2016-10-11
2016-10-11T00:00:00Z
2017-02-21T15:47:10Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.18/4339
url http://hdl.handle.net/10400.18/4339
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv World Mycotoxin Journal. 2016;9(5):791-811. doi:10.3920/WMJ2016.2039. Epub 2016 Oct 11
1875-0710
10.3920/WMJ2016.2039
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wageningen Academic Publishers
publisher.none.fl_str_mv Wageningen Academic Publishers
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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