Altered Gamma-Band Activity as a Potential Biomarker for the Recurrence of Major Depressive Disorder
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.22/13766 |
Resumo: | Background: The neurophysiological mechanisms of cognitive reactivity, the primary vulnerability factor of major depressive disorder (MDD) recurrence, remain unclear in individuals with recovered MDD (rMDD). Because gamma-band responses (GBRs) can be used to measure cognitive processing, they may also be useful for elucidating the mechanisms underlying cognitive reactivity. Identifying these mechanisms may permit the development of an index for predicting and preempting MDD recurrence. Here, to identify the neurophysiological mechanisms of cognitive reactivity, we examined the characteristics of the GBRs evoked/induced by emotional words in participants with and without rMDD after inducing a negative mood. Methods: Thirty-three healthy control participants and 18 participants with rMDD completed a lexical emotion identification task during electroencephalography along with assessments of cognitive reactivity after negative mood induction. Results: No between-group differences were identified for the task reaction times; however, the rMDD group had significantly higher cognitive reactivity scores than did the control group. Furthermore, the power of late GBRs to positive words was significantly greater in the rMDD group, with the greater power of late GBRs being related to higher cognitive reactivity. Limitations: Considering the population studied, our findings cannot be completely generalized to populations other than adolescents, people with rMDD, and those without a history of co-morbid disorders and early life stress. Conclusions: Our findings indicate that the dysfunction of neural circuits related to higher-order processes like memory and attention might underlie cognitive reactivity. Altered late GBRs to positive information may be persistent biomarkers of the depression recurrence risk. |
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Altered Gamma-Band Activity as a Potential Biomarker for the Recurrence of Major Depressive Disordercognitive reactivitydepressionEEGmood inductionbiomarkermemoryBackground: The neurophysiological mechanisms of cognitive reactivity, the primary vulnerability factor of major depressive disorder (MDD) recurrence, remain unclear in individuals with recovered MDD (rMDD). Because gamma-band responses (GBRs) can be used to measure cognitive processing, they may also be useful for elucidating the mechanisms underlying cognitive reactivity. Identifying these mechanisms may permit the development of an index for predicting and preempting MDD recurrence. Here, to identify the neurophysiological mechanisms of cognitive reactivity, we examined the characteristics of the GBRs evoked/induced by emotional words in participants with and without rMDD after inducing a negative mood. Methods: Thirty-three healthy control participants and 18 participants with rMDD completed a lexical emotion identification task during electroencephalography along with assessments of cognitive reactivity after negative mood induction. Results: No between-group differences were identified for the task reaction times; however, the rMDD group had significantly higher cognitive reactivity scores than did the control group. Furthermore, the power of late GBRs to positive words was significantly greater in the rMDD group, with the greater power of late GBRs being related to higher cognitive reactivity. Limitations: Considering the population studied, our findings cannot be completely generalized to populations other than adolescents, people with rMDD, and those without a history of co-morbid disorders and early life stress. Conclusions: Our findings indicate that the dysfunction of neural circuits related to higher-order processes like memory and attention might underlie cognitive reactivity. Altered late GBRs to positive information may be persistent biomarkers of the depression recurrence risk.Repositório Científico do Instituto Politécnico do PortoYamamoto, TetsuyaSugaya, NagisaSiegle, Greg J.Kumano, HiroakiShimada, HironoriMachado, SergioMurillo-Rodriguez, EricRocha, NunoNardi, Antonio E.Takamura, MasahiroOkamoto, YasumasaYamawaki, Shigeto2019-05-21T14:19:43Z20182018-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.22/13766eng10.3389/fpsyt.2018.00691info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-13T12:55:39Zoai:recipp.ipp.pt:10400.22/13766Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:33:37.981048Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Altered Gamma-Band Activity as a Potential Biomarker for the Recurrence of Major Depressive Disorder |
title |
Altered Gamma-Band Activity as a Potential Biomarker for the Recurrence of Major Depressive Disorder |
spellingShingle |
Altered Gamma-Band Activity as a Potential Biomarker for the Recurrence of Major Depressive Disorder Yamamoto, Tetsuya cognitive reactivity depression EEG mood induction biomarker memory |
title_short |
Altered Gamma-Band Activity as a Potential Biomarker for the Recurrence of Major Depressive Disorder |
title_full |
Altered Gamma-Band Activity as a Potential Biomarker for the Recurrence of Major Depressive Disorder |
title_fullStr |
Altered Gamma-Band Activity as a Potential Biomarker for the Recurrence of Major Depressive Disorder |
title_full_unstemmed |
Altered Gamma-Band Activity as a Potential Biomarker for the Recurrence of Major Depressive Disorder |
title_sort |
Altered Gamma-Band Activity as a Potential Biomarker for the Recurrence of Major Depressive Disorder |
author |
Yamamoto, Tetsuya |
author_facet |
Yamamoto, Tetsuya Sugaya, Nagisa Siegle, Greg J. Kumano, Hiroaki Shimada, Hironori Machado, Sergio Murillo-Rodriguez, Eric Rocha, Nuno Nardi, Antonio E. Takamura, Masahiro Okamoto, Yasumasa Yamawaki, Shigeto |
author_role |
author |
author2 |
Sugaya, Nagisa Siegle, Greg J. Kumano, Hiroaki Shimada, Hironori Machado, Sergio Murillo-Rodriguez, Eric Rocha, Nuno Nardi, Antonio E. Takamura, Masahiro Okamoto, Yasumasa Yamawaki, Shigeto |
author2_role |
author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Repositório Científico do Instituto Politécnico do Porto |
dc.contributor.author.fl_str_mv |
Yamamoto, Tetsuya Sugaya, Nagisa Siegle, Greg J. Kumano, Hiroaki Shimada, Hironori Machado, Sergio Murillo-Rodriguez, Eric Rocha, Nuno Nardi, Antonio E. Takamura, Masahiro Okamoto, Yasumasa Yamawaki, Shigeto |
dc.subject.por.fl_str_mv |
cognitive reactivity depression EEG mood induction biomarker memory |
topic |
cognitive reactivity depression EEG mood induction biomarker memory |
description |
Background: The neurophysiological mechanisms of cognitive reactivity, the primary vulnerability factor of major depressive disorder (MDD) recurrence, remain unclear in individuals with recovered MDD (rMDD). Because gamma-band responses (GBRs) can be used to measure cognitive processing, they may also be useful for elucidating the mechanisms underlying cognitive reactivity. Identifying these mechanisms may permit the development of an index for predicting and preempting MDD recurrence. Here, to identify the neurophysiological mechanisms of cognitive reactivity, we examined the characteristics of the GBRs evoked/induced by emotional words in participants with and without rMDD after inducing a negative mood. Methods: Thirty-three healthy control participants and 18 participants with rMDD completed a lexical emotion identification task during electroencephalography along with assessments of cognitive reactivity after negative mood induction. Results: No between-group differences were identified for the task reaction times; however, the rMDD group had significantly higher cognitive reactivity scores than did the control group. Furthermore, the power of late GBRs to positive words was significantly greater in the rMDD group, with the greater power of late GBRs being related to higher cognitive reactivity. Limitations: Considering the population studied, our findings cannot be completely generalized to populations other than adolescents, people with rMDD, and those without a history of co-morbid disorders and early life stress. Conclusions: Our findings indicate that the dysfunction of neural circuits related to higher-order processes like memory and attention might underlie cognitive reactivity. Altered late GBRs to positive information may be persistent biomarkers of the depression recurrence risk. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018 2018-01-01T00:00:00Z 2019-05-21T14:19:43Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.22/13766 |
url |
http://hdl.handle.net/10400.22/13766 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.3389/fpsyt.2018.00691 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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