Prophylactic ondansetron and pregabalin for postoperative nausea and vomiting: a randomized comparative study
Autor(a) principal: | |
---|---|
Data de Publicação: | 2022 |
Outros Autores: | |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://doi.org/10.25751/rspa.26144 |
Resumo: | Introduction: Pregabalin is an antiepileptic drug with antiemetic properties. We evaluated prophylactic oral pregabalin as compared with ondansetron for postoperative nausea and vomiting (PONV) in patients undergoing mastoid surgery in a randomized double-blind study. Material and Methods: Two hundrd patients of ASA physical status I and II, scheduled to undergo mastoid surgery, were randomly assigned into two groups to receive 150 mg pregabalin or 8 mg ondansetron one hour before surgery. Standard anaesthesia technique was used in all patients. Episodes of PONV were recorded during the first 24 h for two time periods: 0–2 and 2–24 h. Data regarding adverse effects, such as dizziness, headache and drowsiness, were also collected. Categorical variables were expressed as frequency (%) and chi-square test was applied to test the significance of association between groups and variables. Continuous variables were expressed as Mean with 95% confidence intervals. T-test was performed to compare the mean of variables between two groups. Kaplan-Meier survival analysis was performed for comparing mean or median time of events. Log-rank test was used to test the median survival time. Kolmogorov-Smirnov test was used for testing the equality of the distribution function of sedative score at each time point. Results: Pregabalin prophylaxis in patients undergoing mastoid surgery delays the onset and decreases the episodes of vomiting within 2-hours of surgery as compared to ondansetron 8mg. It also reduces the incidence of nausea in the postoperative period, albeit at the cost of higher incidence of sedation. Conclusions: Pregabalin effectively suppresses PONV in mastoid surgery. |
id |
RCAP_eb0e36c74decac1f68951994e77d54c3 |
---|---|
oai_identifier_str |
oai:ojs.revistas.rcaap.pt:article/26144 |
network_acronym_str |
RCAP |
network_name_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository_id_str |
7160 |
spelling |
Prophylactic ondansetron and pregabalin for postoperative nausea and vomiting: a randomized comparative studyComparison of Prophylactic Ondansetron and Pregabalin for Postoperative Nausea and Vomiting: A Randomized Controlled StudyArtigo OriginalIntroduction: Pregabalin is an antiepileptic drug with antiemetic properties. We evaluated prophylactic oral pregabalin as compared with ondansetron for postoperative nausea and vomiting (PONV) in patients undergoing mastoid surgery in a randomized double-blind study. Material and Methods: Two hundrd patients of ASA physical status I and II, scheduled to undergo mastoid surgery, were randomly assigned into two groups to receive 150 mg pregabalin or 8 mg ondansetron one hour before surgery. Standard anaesthesia technique was used in all patients. Episodes of PONV were recorded during the first 24 h for two time periods: 0–2 and 2–24 h. Data regarding adverse effects, such as dizziness, headache and drowsiness, were also collected. Categorical variables were expressed as frequency (%) and chi-square test was applied to test the significance of association between groups and variables. Continuous variables were expressed as Mean with 95% confidence intervals. T-test was performed to compare the mean of variables between two groups. Kaplan-Meier survival analysis was performed for comparing mean or median time of events. Log-rank test was used to test the median survival time. Kolmogorov-Smirnov test was used for testing the equality of the distribution function of sedative score at each time point. Results: Pregabalin prophylaxis in patients undergoing mastoid surgery delays the onset and decreases the episodes of vomiting within 2-hours of surgery as compared to ondansetron 8mg. It also reduces the incidence of nausea in the postoperative period, albeit at the cost of higher incidence of sedation. Conclusions: Pregabalin effectively suppresses PONV in mastoid surgery.Sociedade Portuguesa de Anestesiologia2022-06-30T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://doi.org/10.25751/rspa.26144eng0871-6099Raihan, UzmaDubey, Prakashinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-09-23T15:34:54Zoai:ojs.revistas.rcaap.pt:article/26144Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:04:21.041116Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Prophylactic ondansetron and pregabalin for postoperative nausea and vomiting: a randomized comparative study Comparison of Prophylactic Ondansetron and Pregabalin for Postoperative Nausea and Vomiting: A Randomized Controlled Study |
title |
Prophylactic ondansetron and pregabalin for postoperative nausea and vomiting: a randomized comparative study |
spellingShingle |
Prophylactic ondansetron and pregabalin for postoperative nausea and vomiting: a randomized comparative study Raihan, Uzma Artigo Original |
title_short |
Prophylactic ondansetron and pregabalin for postoperative nausea and vomiting: a randomized comparative study |
title_full |
Prophylactic ondansetron and pregabalin for postoperative nausea and vomiting: a randomized comparative study |
title_fullStr |
Prophylactic ondansetron and pregabalin for postoperative nausea and vomiting: a randomized comparative study |
title_full_unstemmed |
Prophylactic ondansetron and pregabalin for postoperative nausea and vomiting: a randomized comparative study |
title_sort |
Prophylactic ondansetron and pregabalin for postoperative nausea and vomiting: a randomized comparative study |
author |
Raihan, Uzma |
author_facet |
Raihan, Uzma Dubey, Prakash |
author_role |
author |
author2 |
Dubey, Prakash |
author2_role |
author |
dc.contributor.author.fl_str_mv |
Raihan, Uzma Dubey, Prakash |
dc.subject.por.fl_str_mv |
Artigo Original |
topic |
Artigo Original |
description |
Introduction: Pregabalin is an antiepileptic drug with antiemetic properties. We evaluated prophylactic oral pregabalin as compared with ondansetron for postoperative nausea and vomiting (PONV) in patients undergoing mastoid surgery in a randomized double-blind study. Material and Methods: Two hundrd patients of ASA physical status I and II, scheduled to undergo mastoid surgery, were randomly assigned into two groups to receive 150 mg pregabalin or 8 mg ondansetron one hour before surgery. Standard anaesthesia technique was used in all patients. Episodes of PONV were recorded during the first 24 h for two time periods: 0–2 and 2–24 h. Data regarding adverse effects, such as dizziness, headache and drowsiness, were also collected. Categorical variables were expressed as frequency (%) and chi-square test was applied to test the significance of association between groups and variables. Continuous variables were expressed as Mean with 95% confidence intervals. T-test was performed to compare the mean of variables between two groups. Kaplan-Meier survival analysis was performed for comparing mean or median time of events. Log-rank test was used to test the median survival time. Kolmogorov-Smirnov test was used for testing the equality of the distribution function of sedative score at each time point. Results: Pregabalin prophylaxis in patients undergoing mastoid surgery delays the onset and decreases the episodes of vomiting within 2-hours of surgery as compared to ondansetron 8mg. It also reduces the incidence of nausea in the postoperative period, albeit at the cost of higher incidence of sedation. Conclusions: Pregabalin effectively suppresses PONV in mastoid surgery. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-06-30T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://doi.org/10.25751/rspa.26144 |
url |
https://doi.org/10.25751/rspa.26144 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
0871-6099 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Sociedade Portuguesa de Anestesiologia |
publisher.none.fl_str_mv |
Sociedade Portuguesa de Anestesiologia |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
|
_version_ |
1799130506661462016 |