Potentiating angiogenesis arrest in vivo via laser irradiation of peptide functionalised gold nanoparticles

Detalhes bibliográficos
Autor(a) principal: Pedrosa, Pedro
Data de Publicação: 2017
Outros Autores: Heuer-Jungemann, Amelie, Kanaras, Antonios G., Fernandes, Alexandra R., Baptista, Pedro V.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/146941
Resumo: national funds from FCT/MEC (UID/Multi/04378/2013) and co-financed by the ERDF under the PT2020 Partnership Agreement (POCI-01-0145-FEDER-007728); PP for PD/BD/105734/2014
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spelling Potentiating angiogenesis arrest in vivo via laser irradiation of peptide functionalised gold nanoparticlesAngiogenesisCAM assayGold nanoparticlesGreen laserPhototherapyVEGFR pathwayBioengineeringMedicine (miscellaneous)Molecular MedicineBiomedical EngineeringApplied Microbiology and BiotechnologyPharmaceutical ScienceSDG 3 - Good Health and Well-beingnational funds from FCT/MEC (UID/Multi/04378/2013) and co-financed by the ERDF under the PT2020 Partnership Agreement (POCI-01-0145-FEDER-007728); PP for PD/BD/105734/2014Background: Anti-angiogenic therapy has great potential for cancer therapy with several FDA approved formulations but there are considerable side effects upon the normal blood vessels that decrease the potential application of such therapeutics. Chicken chorioallantoic membrane (CAM) has been used as a model to study angiogenesis in vivo. Using a CAM model, it had been previously shown that spherical gold nanoparticles functionalised with an anti-angiogenic peptide can humper neo-angiogenesis. Results: Our results show that gold nanoparticles conjugated with an anti-angiogenic peptide can be combined with visible laser irradiation to enhance angiogenesis arrest in vivo. We show that a green laser coupled to gold nanoparticles can achieve high localized temperatures able to precisely cauterize blood vessels. This combined therapy acts via VEGFR pathway inhibition, leading to a fourfold reduction in FLT-1 expression. Conclusions: The proposed phototherapy extends the use of visible lasers in clinics, combining it with chemotherapy to potentiate cancer treatment. This approach allows the reduction of dose of anti-angiogenic peptide, thus reducing possible side effects, while destroying blood vessels supply critical for tumour progression.UCIBIO - Applied Molecular Biosciences UnitDCV - Departamento de Ciências da VidaRUNPedrosa, PedroHeuer-Jungemann, AmelieKanaras, Antonios G.Fernandes, Alexandra R.Baptista, Pedro V.2023-01-04T22:10:21Z2017-11-212017-11-21T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/146941eng1477-3155PURE: 3851176https://doi.org/10.1186/s12951-017-0321-2info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:27:53Zoai:run.unl.pt:10362/146941Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:52:43.031564Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Potentiating angiogenesis arrest in vivo via laser irradiation of peptide functionalised gold nanoparticles
title Potentiating angiogenesis arrest in vivo via laser irradiation of peptide functionalised gold nanoparticles
spellingShingle Potentiating angiogenesis arrest in vivo via laser irradiation of peptide functionalised gold nanoparticles
Pedrosa, Pedro
Angiogenesis
CAM assay
Gold nanoparticles
Green laser
Phototherapy
VEGFR pathway
Bioengineering
Medicine (miscellaneous)
Molecular Medicine
Biomedical Engineering
Applied Microbiology and Biotechnology
Pharmaceutical Science
SDG 3 - Good Health and Well-being
title_short Potentiating angiogenesis arrest in vivo via laser irradiation of peptide functionalised gold nanoparticles
title_full Potentiating angiogenesis arrest in vivo via laser irradiation of peptide functionalised gold nanoparticles
title_fullStr Potentiating angiogenesis arrest in vivo via laser irradiation of peptide functionalised gold nanoparticles
title_full_unstemmed Potentiating angiogenesis arrest in vivo via laser irradiation of peptide functionalised gold nanoparticles
title_sort Potentiating angiogenesis arrest in vivo via laser irradiation of peptide functionalised gold nanoparticles
author Pedrosa, Pedro
author_facet Pedrosa, Pedro
Heuer-Jungemann, Amelie
Kanaras, Antonios G.
Fernandes, Alexandra R.
Baptista, Pedro V.
author_role author
author2 Heuer-Jungemann, Amelie
Kanaras, Antonios G.
Fernandes, Alexandra R.
Baptista, Pedro V.
author2_role author
author
author
author
dc.contributor.none.fl_str_mv UCIBIO - Applied Molecular Biosciences Unit
DCV - Departamento de Ciências da Vida
RUN
dc.contributor.author.fl_str_mv Pedrosa, Pedro
Heuer-Jungemann, Amelie
Kanaras, Antonios G.
Fernandes, Alexandra R.
Baptista, Pedro V.
dc.subject.por.fl_str_mv Angiogenesis
CAM assay
Gold nanoparticles
Green laser
Phototherapy
VEGFR pathway
Bioengineering
Medicine (miscellaneous)
Molecular Medicine
Biomedical Engineering
Applied Microbiology and Biotechnology
Pharmaceutical Science
SDG 3 - Good Health and Well-being
topic Angiogenesis
CAM assay
Gold nanoparticles
Green laser
Phototherapy
VEGFR pathway
Bioengineering
Medicine (miscellaneous)
Molecular Medicine
Biomedical Engineering
Applied Microbiology and Biotechnology
Pharmaceutical Science
SDG 3 - Good Health and Well-being
description national funds from FCT/MEC (UID/Multi/04378/2013) and co-financed by the ERDF under the PT2020 Partnership Agreement (POCI-01-0145-FEDER-007728); PP for PD/BD/105734/2014
publishDate 2017
dc.date.none.fl_str_mv 2017-11-21
2017-11-21T00:00:00Z
2023-01-04T22:10:21Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/146941
url http://hdl.handle.net/10362/146941
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1477-3155
PURE: 3851176
https://doi.org/10.1186/s12951-017-0321-2
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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