Structural analysis of dextrins and characterization of dextrin-based biomedical hydrogels

Detalhes bibliográficos
Autor(a) principal: Silva, Dina M.
Data de Publicação: 2014
Outros Autores: Nunes, Cláudia, Pereira, Isabel Sofia Melo, Moreira, Ana S. P., Domingues, M. R. M., Coimbra, Manuel A., Gama, F. M.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/31818
Resumo: The characterization of several commercial dextrins and the analysis of the potential of dextrin derived hydrogels for biomedical applications were performed in this work. The structural characterization of dextrins allowed the determination of the polymerization and branching degrees, which ranged from 6 to 17 glucose residues and 2 to 13%, respectively. Tackidex, a medical grade dextrin was choosen for further characterization. The combination of hydrogel with a dextrin nanogel and urinary bladder matrix was achieved without compromising the mechanical properties or microstructure. The encapsulation of cells, preserving its viability, confirms the biocompatibility of the injectable hydrogels, which have therefore great potential for biomedical applications.
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spelling Structural analysis of dextrins and characterization of dextrin-based biomedical hydrogelsDextrinInjectable hydrogelsStructural analysisMALDI-MSSECMALDI-MS SECScience & TechnologyThe characterization of several commercial dextrins and the analysis of the potential of dextrin derived hydrogels for biomedical applications were performed in this work. The structural characterization of dextrins allowed the determination of the polymerization and branching degrees, which ranged from 6 to 17 glucose residues and 2 to 13%, respectively. Tackidex, a medical grade dextrin was choosen for further characterization. The combination of hydrogel with a dextrin nanogel and urinary bladder matrix was achieved without compromising the mechanical properties or microstructure. The encapsulation of cells, preserving its viability, confirms the biocompatibility of the injectable hydrogels, which have therefore great potential for biomedical applications.D.M.S. was supported by the grant SFRH/BD/64571/2009 from Fundacao para a Ciencia e Tecnologia (FCT), Portugal. We thank FCT funding through EuroNanoMed ENMED/0002/2010. The authors acknowledge the funding from QREN ("Quadro de Referencia Estrategica Nacional") and ADI ("Agencia de Inovacao") through the project Norte-07-0202-FEDER-038853.QOPNA research unit is funded by Fundacao para a Ciencia e a Tecnologia (FCT, Portugal, European Union, QREN, FEDER, and COMPETE (project PEst-C/QUI/UI0062/2013; FCOMP-01-0124-FEDER-037296), and the Portuguese National Mass Spectrometry Network, and Project PTDC/QUI-QUI/100044/2008. Ana S. P. Moreira and Claudia Nunes thanks FCT the grants (SFRH/BD/80553/2011; SFRH/BPD/46584/2008). The authors thank Prof. Dmitry V. Evtuguin for the use of SEC equipment.ElsevierUniversidade do MinhoSilva, Dina M.Nunes, CláudiaPereira, Isabel Sofia MeloMoreira, Ana S. P.Domingues, M. R. M.Coimbra, Manuel A.Gama, F. M.20142014-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/31818eng0144-86170144-861710.1016/j.carbpol.2014.08.00925263914http://www.journals.elsevier.com/carbohydrate-polymers/info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:20:32Zoai:repositorium.sdum.uminho.pt:1822/31818Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:13:43.061614Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Structural analysis of dextrins and characterization of dextrin-based biomedical hydrogels
title Structural analysis of dextrins and characterization of dextrin-based biomedical hydrogels
spellingShingle Structural analysis of dextrins and characterization of dextrin-based biomedical hydrogels
Silva, Dina M.
Dextrin
Injectable hydrogels
Structural analysis
MALDI-MS
SEC
MALDI-MS SEC
Science & Technology
title_short Structural analysis of dextrins and characterization of dextrin-based biomedical hydrogels
title_full Structural analysis of dextrins and characterization of dextrin-based biomedical hydrogels
title_fullStr Structural analysis of dextrins and characterization of dextrin-based biomedical hydrogels
title_full_unstemmed Structural analysis of dextrins and characterization of dextrin-based biomedical hydrogels
title_sort Structural analysis of dextrins and characterization of dextrin-based biomedical hydrogels
author Silva, Dina M.
author_facet Silva, Dina M.
Nunes, Cláudia
Pereira, Isabel Sofia Melo
Moreira, Ana S. P.
Domingues, M. R. M.
Coimbra, Manuel A.
Gama, F. M.
author_role author
author2 Nunes, Cláudia
Pereira, Isabel Sofia Melo
Moreira, Ana S. P.
Domingues, M. R. M.
Coimbra, Manuel A.
Gama, F. M.
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Silva, Dina M.
Nunes, Cláudia
Pereira, Isabel Sofia Melo
Moreira, Ana S. P.
Domingues, M. R. M.
Coimbra, Manuel A.
Gama, F. M.
dc.subject.por.fl_str_mv Dextrin
Injectable hydrogels
Structural analysis
MALDI-MS
SEC
MALDI-MS SEC
Science & Technology
topic Dextrin
Injectable hydrogels
Structural analysis
MALDI-MS
SEC
MALDI-MS SEC
Science & Technology
description The characterization of several commercial dextrins and the analysis of the potential of dextrin derived hydrogels for biomedical applications were performed in this work. The structural characterization of dextrins allowed the determination of the polymerization and branching degrees, which ranged from 6 to 17 glucose residues and 2 to 13%, respectively. Tackidex, a medical grade dextrin was choosen for further characterization. The combination of hydrogel with a dextrin nanogel and urinary bladder matrix was achieved without compromising the mechanical properties or microstructure. The encapsulation of cells, preserving its viability, confirms the biocompatibility of the injectable hydrogels, which have therefore great potential for biomedical applications.
publishDate 2014
dc.date.none.fl_str_mv 2014
2014-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/31818
url http://hdl.handle.net/1822/31818
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0144-8617
0144-8617
10.1016/j.carbpol.2014.08.009
25263914
http://www.journals.elsevier.com/carbohydrate-polymers/
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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