Preparation of biodegradable functionalized polyesters aimed to be used as surgical adhesives
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.6/7097 |
Resumo: | The study and development of new biocompatible materials to be applied as UV-curable adhesives is extremely important to grant the preparation of matrices with suitable mechanical, biological and thermal properties with a fast curing rate. Herein, photocrosslinkable biodegradable copolymers composed of unsaturated polyesters (UP) and lactic acid oligomers functionalized with 2-isocyanatoethyl methacrylate (IEMA) were produced. Henceforth, three different stoichiometric proportions were tested, which, after the addition of a biocompatible photoinitiator (Irgacure® 2959), resulted in flexible, resistant and uniform matrices after 2 minutes and 30 seconds of crosslinking. The synthesized materials were then further characterized in terms of chemical composition and thermal/mechanical behaviour. The gel content, dynamic contact angles, water sorption capacity and hydrolytic degradation were also assessed. The biocompatibility and antibacterial activity of the produced materials was also evaluated. Taking into account all the data obtained, it may be concluded that the new synthesized biodegradable bioadhesives present promising properties to be used as surgical adhesives. |
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Preparation of biodegradable functionalized polyesters aimed to be used as surgical adhesivesSurgical adhesivePolyesterPhotocrosslinkable copolymersBiocompatibilityBiodegradabilityThe study and development of new biocompatible materials to be applied as UV-curable adhesives is extremely important to grant the preparation of matrices with suitable mechanical, biological and thermal properties with a fast curing rate. Herein, photocrosslinkable biodegradable copolymers composed of unsaturated polyesters (UP) and lactic acid oligomers functionalized with 2-isocyanatoethyl methacrylate (IEMA) were produced. Henceforth, three different stoichiometric proportions were tested, which, after the addition of a biocompatible photoinitiator (Irgacure® 2959), resulted in flexible, resistant and uniform matrices after 2 minutes and 30 seconds of crosslinking. The synthesized materials were then further characterized in terms of chemical composition and thermal/mechanical behaviour. The gel content, dynamic contact angles, water sorption capacity and hydrolytic degradation were also assessed. The biocompatibility and antibacterial activity of the produced materials was also evaluated. Taking into account all the data obtained, it may be concluded that the new synthesized biodegradable bioadhesives present promising properties to be used as surgical adhesives.ElsevieruBibliorumCernadas, Maria TeresaGonçalves, Filipa A.M.M.Alves, P.Miguel, Sónia P.Cabral, C.S.D.Correia, I.J.Ferreira, Paula2021-05-22T00:30:12Z2019-05-112019-05-11T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.6/7097eng10.1016/j.eurpolymj.2019.05.019info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-12-15T09:46:11Zoai:ubibliorum.ubi.pt:10400.6/7097Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T00:47:41.077220Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Preparation of biodegradable functionalized polyesters aimed to be used as surgical adhesives |
title |
Preparation of biodegradable functionalized polyesters aimed to be used as surgical adhesives |
spellingShingle |
Preparation of biodegradable functionalized polyesters aimed to be used as surgical adhesives Cernadas, Maria Teresa Surgical adhesive Polyester Photocrosslinkable copolymers Biocompatibility Biodegradability |
title_short |
Preparation of biodegradable functionalized polyesters aimed to be used as surgical adhesives |
title_full |
Preparation of biodegradable functionalized polyesters aimed to be used as surgical adhesives |
title_fullStr |
Preparation of biodegradable functionalized polyesters aimed to be used as surgical adhesives |
title_full_unstemmed |
Preparation of biodegradable functionalized polyesters aimed to be used as surgical adhesives |
title_sort |
Preparation of biodegradable functionalized polyesters aimed to be used as surgical adhesives |
author |
Cernadas, Maria Teresa |
author_facet |
Cernadas, Maria Teresa Gonçalves, Filipa A.M.M. Alves, P. Miguel, Sónia P. Cabral, C.S.D. Correia, I.J. Ferreira, Paula |
author_role |
author |
author2 |
Gonçalves, Filipa A.M.M. Alves, P. Miguel, Sónia P. Cabral, C.S.D. Correia, I.J. Ferreira, Paula |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
uBibliorum |
dc.contributor.author.fl_str_mv |
Cernadas, Maria Teresa Gonçalves, Filipa A.M.M. Alves, P. Miguel, Sónia P. Cabral, C.S.D. Correia, I.J. Ferreira, Paula |
dc.subject.por.fl_str_mv |
Surgical adhesive Polyester Photocrosslinkable copolymers Biocompatibility Biodegradability |
topic |
Surgical adhesive Polyester Photocrosslinkable copolymers Biocompatibility Biodegradability |
description |
The study and development of new biocompatible materials to be applied as UV-curable adhesives is extremely important to grant the preparation of matrices with suitable mechanical, biological and thermal properties with a fast curing rate. Herein, photocrosslinkable biodegradable copolymers composed of unsaturated polyesters (UP) and lactic acid oligomers functionalized with 2-isocyanatoethyl methacrylate (IEMA) were produced. Henceforth, three different stoichiometric proportions were tested, which, after the addition of a biocompatible photoinitiator (Irgacure® 2959), resulted in flexible, resistant and uniform matrices after 2 minutes and 30 seconds of crosslinking. The synthesized materials were then further characterized in terms of chemical composition and thermal/mechanical behaviour. The gel content, dynamic contact angles, water sorption capacity and hydrolytic degradation were also assessed. The biocompatibility and antibacterial activity of the produced materials was also evaluated. Taking into account all the data obtained, it may be concluded that the new synthesized biodegradable bioadhesives present promising properties to be used as surgical adhesives. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-05-11 2019-05-11T00:00:00Z 2021-05-22T00:30:12Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.6/7097 |
url |
http://hdl.handle.net/10400.6/7097 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1016/j.eurpolymj.2019.05.019 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799136372014972928 |