Hypersensitivity to thimerosal: the sensitizing moiety
Autor(a) principal: | |
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Data de Publicação: | 1996 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.4/687 |
Resumo: | There has been increasing interest in characterizing the sensitizing moiety of thimerosal [TIM], following the finding that patients with photosensitivity to piroxicam are allergic to the thiosalicylic acid [TIO] moiety of TIM. For this purpose, the authors have conducted 2 studies in TIM-sensitive patients. In the 1st, of 175 patients tested with TIO and ammoniated mercuric chloride [HGAM], 45.7% reacted only to TIM, whereas 45.7% reacted also to TIO and 17.7% also to HGAM; 9.1% reacted to both TIO and HGAM. In the 2nd, of 47 patients tested with TIO and ethylmercuric chloride [ETHG], 87.2% reacted to ETHG, 44.7% to TIO and 31.9% reacted to both. None of the patients reacted only to TIM. The authors conclude that thimerosal allergy is due either to the mercuric moiety or to thiosalicylic acid, with no cases of sensitivity only to the whole molecule of TIM. TIM-sensitive patients are mainly allergic to the mercuric moiety, but among them there are a large number of TIO-sensitive patients, and these should be advised to avoid piroxicam. |
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Hypersensitivity to thimerosal: the sensitizing moietyDermatite de Contacto AlérgicaTimerosalThere has been increasing interest in characterizing the sensitizing moiety of thimerosal [TIM], following the finding that patients with photosensitivity to piroxicam are allergic to the thiosalicylic acid [TIO] moiety of TIM. For this purpose, the authors have conducted 2 studies in TIM-sensitive patients. In the 1st, of 175 patients tested with TIO and ammoniated mercuric chloride [HGAM], 45.7% reacted only to TIM, whereas 45.7% reacted also to TIO and 17.7% also to HGAM; 9.1% reacted to both TIO and HGAM. In the 2nd, of 47 patients tested with TIO and ethylmercuric chloride [ETHG], 87.2% reacted to ETHG, 44.7% to TIO and 31.9% reacted to both. None of the patients reacted only to TIM. The authors conclude that thimerosal allergy is due either to the mercuric moiety or to thiosalicylic acid, with no cases of sensitivity only to the whole molecule of TIM. TIM-sensitive patients are mainly allergic to the mercuric moiety, but among them there are a large number of TIO-sensitive patients, and these should be advised to avoid piroxicam.MunksgaardRIHUCGonçalo, MargaridaFigueiredo, AGonçalo, S2009-11-19T16:04:29Z19961996-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.4/687engContact Dermatitis. 1996 Mar;34(3):201-3.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-11T14:21:51Zoai:rihuc.huc.min-saude.pt:10400.4/687Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:03:14.837843Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Hypersensitivity to thimerosal: the sensitizing moiety |
title |
Hypersensitivity to thimerosal: the sensitizing moiety |
spellingShingle |
Hypersensitivity to thimerosal: the sensitizing moiety Gonçalo, Margarida Dermatite de Contacto Alérgica Timerosal |
title_short |
Hypersensitivity to thimerosal: the sensitizing moiety |
title_full |
Hypersensitivity to thimerosal: the sensitizing moiety |
title_fullStr |
Hypersensitivity to thimerosal: the sensitizing moiety |
title_full_unstemmed |
Hypersensitivity to thimerosal: the sensitizing moiety |
title_sort |
Hypersensitivity to thimerosal: the sensitizing moiety |
author |
Gonçalo, Margarida |
author_facet |
Gonçalo, Margarida Figueiredo, A Gonçalo, S |
author_role |
author |
author2 |
Figueiredo, A Gonçalo, S |
author2_role |
author author |
dc.contributor.none.fl_str_mv |
RIHUC |
dc.contributor.author.fl_str_mv |
Gonçalo, Margarida Figueiredo, A Gonçalo, S |
dc.subject.por.fl_str_mv |
Dermatite de Contacto Alérgica Timerosal |
topic |
Dermatite de Contacto Alérgica Timerosal |
description |
There has been increasing interest in characterizing the sensitizing moiety of thimerosal [TIM], following the finding that patients with photosensitivity to piroxicam are allergic to the thiosalicylic acid [TIO] moiety of TIM. For this purpose, the authors have conducted 2 studies in TIM-sensitive patients. In the 1st, of 175 patients tested with TIO and ammoniated mercuric chloride [HGAM], 45.7% reacted only to TIM, whereas 45.7% reacted also to TIO and 17.7% also to HGAM; 9.1% reacted to both TIO and HGAM. In the 2nd, of 47 patients tested with TIO and ethylmercuric chloride [ETHG], 87.2% reacted to ETHG, 44.7% to TIO and 31.9% reacted to both. None of the patients reacted only to TIM. The authors conclude that thimerosal allergy is due either to the mercuric moiety or to thiosalicylic acid, with no cases of sensitivity only to the whole molecule of TIM. TIM-sensitive patients are mainly allergic to the mercuric moiety, but among them there are a large number of TIO-sensitive patients, and these should be advised to avoid piroxicam. |
publishDate |
1996 |
dc.date.none.fl_str_mv |
1996 1996-01-01T00:00:00Z 2009-11-19T16:04:29Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.4/687 |
url |
http://hdl.handle.net/10400.4/687 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Contact Dermatitis. 1996 Mar;34(3):201-3. |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Munksgaard |
publisher.none.fl_str_mv |
Munksgaard |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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