Phylogenomic characterization and signs of microevolution in the 2022 multi-country outbreak of monkeypox virus

Detalhes bibliográficos
Autor(a) principal: Isidro, Joana
Data de Publicação: 2022
Outros Autores: Borges, Vítor, Pinto, Miguel, Sobral, Daniel, Santos, João Dourado, Nunes, Alexandra, Mixão, Verónica, Ferreira, Rita, Santos, Daniela, Duarte, Silvia, Vieira, Luís, Borrego, Maria José, Núncio, Sofia, de Carvalho, Isabel Lopes, Pelerito, Ana, Cordeiro, Rita, Gomes, João Paulo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.18/8471
Resumo: Trabalho distinguido com o Prémio João Monjardino 2022.
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spelling Phylogenomic characterization and signs of microevolution in the 2022 multi-country outbreak of monkeypox virusMonkeypoxMonkeypox VirusMonkeypox / geneticsMonkeypox / epidemiologyPhylogenyZoonotic DiseaseDisease OutbreaksHumansInfecções Sistémicas e ZoonosesTrabalho distinguido com o Prémio João Monjardino 2022.https://www.insa.min-saude.pt/investigadora-do-instituto-ricardo-jorge-vence-premio-joao-monjardino-2022/s41591-022-02036-2_Erratum in: Nat Med. 2022 Oct;28(10):2220-2221. doi: 10.1038/s41591-022-02036-2.The largest monkeypox virus (MPXV) outbreak described so far in non-endemic countries was identified in May 2022 (refs. 1-6). In this study, shotgun metagenomics allowed the rapid reconstruction and phylogenomic characterization of the first MPXV outbreak genome sequences, showing that this MPXV belongs to clade 3 and that the outbreak most likely has a single origin. Although 2022 MPXV (lineage B.1) clustered with 2018-2019 cases linked to an endemic country, it segregates in a divergent phylogenetic branch, likely reflecting continuous accelerated evolution. An in-depth mutational analysis suggests the action of host APOBEC3 in viral evolution as well as signs of potential MPXV human adaptation in ongoing microevolution. Our findings also indicate that genome sequencing may provide resolution to track the spread and transmission of this presumably slow-evolving double-stranded DNA virus.Nature ResearchRepositório Científico do Instituto Nacional de SaúdeIsidro, JoanaBorges, VítorPinto, MiguelSobral, DanielSantos, João DouradoNunes, AlexandraMixão, VerónicaFerreira, RitaSantos, DanielaDuarte, SilviaVieira, LuísBorrego, Maria JoséNúncio, Sofiade Carvalho, Isabel LopesPelerito, AnaCordeiro, RitaGomes, João Paulo2023-01-30T13:32:45Z2022-082022-08-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfapplication/pdfhttp://hdl.handle.net/10400.18/8471engNat Med. 2022 Aug;28(8):1569-1572. doi: 10.1038/s41591-022-01907-y. Epub 2022 Jun 24.1078-895610.1038/s41591-022-01907-yinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-20T15:42:35Zoai:repositorio.insa.pt:10400.18/8471Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:43:06.019689Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Phylogenomic characterization and signs of microevolution in the 2022 multi-country outbreak of monkeypox virus
title Phylogenomic characterization and signs of microevolution in the 2022 multi-country outbreak of monkeypox virus
spellingShingle Phylogenomic characterization and signs of microevolution in the 2022 multi-country outbreak of monkeypox virus
Isidro, Joana
Monkeypox
Monkeypox Virus
Monkeypox / genetics
Monkeypox / epidemiology
Phylogeny
Zoonotic Disease
Disease Outbreaks
Humans
Infecções Sistémicas e Zoonoses
title_short Phylogenomic characterization and signs of microevolution in the 2022 multi-country outbreak of monkeypox virus
title_full Phylogenomic characterization and signs of microevolution in the 2022 multi-country outbreak of monkeypox virus
title_fullStr Phylogenomic characterization and signs of microevolution in the 2022 multi-country outbreak of monkeypox virus
title_full_unstemmed Phylogenomic characterization and signs of microevolution in the 2022 multi-country outbreak of monkeypox virus
title_sort Phylogenomic characterization and signs of microevolution in the 2022 multi-country outbreak of monkeypox virus
author Isidro, Joana
author_facet Isidro, Joana
Borges, Vítor
Pinto, Miguel
Sobral, Daniel
Santos, João Dourado
Nunes, Alexandra
Mixão, Verónica
Ferreira, Rita
Santos, Daniela
Duarte, Silvia
Vieira, Luís
Borrego, Maria José
Núncio, Sofia
de Carvalho, Isabel Lopes
Pelerito, Ana
Cordeiro, Rita
Gomes, João Paulo
author_role author
author2 Borges, Vítor
Pinto, Miguel
Sobral, Daniel
Santos, João Dourado
Nunes, Alexandra
Mixão, Verónica
Ferreira, Rita
Santos, Daniela
Duarte, Silvia
Vieira, Luís
Borrego, Maria José
Núncio, Sofia
de Carvalho, Isabel Lopes
Pelerito, Ana
Cordeiro, Rita
Gomes, João Paulo
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório Científico do Instituto Nacional de Saúde
dc.contributor.author.fl_str_mv Isidro, Joana
Borges, Vítor
Pinto, Miguel
Sobral, Daniel
Santos, João Dourado
Nunes, Alexandra
Mixão, Verónica
Ferreira, Rita
Santos, Daniela
Duarte, Silvia
Vieira, Luís
Borrego, Maria José
Núncio, Sofia
de Carvalho, Isabel Lopes
Pelerito, Ana
Cordeiro, Rita
Gomes, João Paulo
dc.subject.por.fl_str_mv Monkeypox
Monkeypox Virus
Monkeypox / genetics
Monkeypox / epidemiology
Phylogeny
Zoonotic Disease
Disease Outbreaks
Humans
Infecções Sistémicas e Zoonoses
topic Monkeypox
Monkeypox Virus
Monkeypox / genetics
Monkeypox / epidemiology
Phylogeny
Zoonotic Disease
Disease Outbreaks
Humans
Infecções Sistémicas e Zoonoses
description Trabalho distinguido com o Prémio João Monjardino 2022.
publishDate 2022
dc.date.none.fl_str_mv 2022-08
2022-08-01T00:00:00Z
2023-01-30T13:32:45Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.18/8471
url http://hdl.handle.net/10400.18/8471
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Nat Med. 2022 Aug;28(8):1569-1572. doi: 10.1038/s41591-022-01907-y. Epub 2022 Jun 24.
1078-8956
10.1038/s41591-022-01907-y
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Nature Research
publisher.none.fl_str_mv Nature Research
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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