Selective Recognition of Amino Acids and Peptides by Small Supramolecular Receptors

Detalhes bibliográficos
Autor(a) principal: Martins, Joana N.
Data de Publicação: 2021
Outros Autores: Lima, João Carlos, Basílio, Nuno
Tipo de documento: Outros
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/114142
Resumo: UIDB/50006/2020
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network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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spelling Selective Recognition of Amino Acids and Peptides by Small Supramolecular Receptorsamino acidshost-guest systemsmolecular recognitionpeptidessupramolecular receptorsAnalytical ChemistryChemistry (miscellaneous)Molecular MedicinePharmaceutical ScienceDrug DiscoveryPhysical and Theoretical ChemistryOrganic ChemistryUIDB/50006/2020To this day, the recognition and high affinity binding of biomolecules in water by synthetic receptors remains challenging, while the necessity for systems for their sensing, transport and modulation persists. This problematic is prevalent for the recognition of peptides, which not only have key roles in many biochemical pathways, as well as having pharmacological and biotechnological applications, but also frequently serve as models for the study of proteins. Taking inspiration in nature and on the interactions that occur between several receptors and peptide sequences, many researchers have developed and applied a variety of different synthetic receptors, as is the case of macrocyclic compounds, molecular imprinted polymers, organometallic cages, among others, to bind amino acids, small peptides and proteins. In this critical review, we present and discuss selected examples of synthetic receptors for amino acids and peptides, with a greater focus on supramolecular receptors, which show great promise for the selective recognition of these biomolecules in physiological conditions. We decided to focus preferentially on small synthetic receptors (leaving out of this review high molecular weight polymeric systems) for which more detailed and accurate molecular level information regarding the main structural and thermodynamic features of the receptor biomolecule assemblies is available.DQ - Departamento de QuímicaLAQV@REQUIMTERUNMartins, Joana N.Lima, João CarlosBasílio, Nuno2021-03-19T23:28:14Z2021-01-012021-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/otherapplication/pdfhttp://hdl.handle.net/10362/114142engPURE: 27671823https://doi.org/10.3390/molecules26010106info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-05-22T17:51:16Zoai:run.unl.pt:10362/114142Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-05-22T17:51:16Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Selective Recognition of Amino Acids and Peptides by Small Supramolecular Receptors
title Selective Recognition of Amino Acids and Peptides by Small Supramolecular Receptors
spellingShingle Selective Recognition of Amino Acids and Peptides by Small Supramolecular Receptors
Martins, Joana N.
amino acids
host-guest systems
molecular recognition
peptides
supramolecular receptors
Analytical Chemistry
Chemistry (miscellaneous)
Molecular Medicine
Pharmaceutical Science
Drug Discovery
Physical and Theoretical Chemistry
Organic Chemistry
title_short Selective Recognition of Amino Acids and Peptides by Small Supramolecular Receptors
title_full Selective Recognition of Amino Acids and Peptides by Small Supramolecular Receptors
title_fullStr Selective Recognition of Amino Acids and Peptides by Small Supramolecular Receptors
title_full_unstemmed Selective Recognition of Amino Acids and Peptides by Small Supramolecular Receptors
title_sort Selective Recognition of Amino Acids and Peptides by Small Supramolecular Receptors
author Martins, Joana N.
author_facet Martins, Joana N.
Lima, João Carlos
Basílio, Nuno
author_role author
author2 Lima, João Carlos
Basílio, Nuno
author2_role author
author
dc.contributor.none.fl_str_mv DQ - Departamento de Química
LAQV@REQUIMTE
RUN
dc.contributor.author.fl_str_mv Martins, Joana N.
Lima, João Carlos
Basílio, Nuno
dc.subject.por.fl_str_mv amino acids
host-guest systems
molecular recognition
peptides
supramolecular receptors
Analytical Chemistry
Chemistry (miscellaneous)
Molecular Medicine
Pharmaceutical Science
Drug Discovery
Physical and Theoretical Chemistry
Organic Chemistry
topic amino acids
host-guest systems
molecular recognition
peptides
supramolecular receptors
Analytical Chemistry
Chemistry (miscellaneous)
Molecular Medicine
Pharmaceutical Science
Drug Discovery
Physical and Theoretical Chemistry
Organic Chemistry
description UIDB/50006/2020
publishDate 2021
dc.date.none.fl_str_mv 2021-03-19T23:28:14Z
2021-01-01
2021-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/other
format other
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/114142
url http://hdl.handle.net/10362/114142
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv PURE: 27671823
https://doi.org/10.3390/molecules26010106
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv mluisa.alvim@gmail.com
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